Protein Alignment spok and CYP2C18

DIOPT Version :9

• Sequence 1: NP_001104460.2
• Gene: spok / 5740359
• FlyBaseID: FBgn0086917
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_000763.1
• Gene: CYP2C18 / 1562
• HGNCID: 2620
• Length: 490
• Species: Homo sapiens
• Alignment Length: 548
• Identity: 138/548 - (25%)
• Similarity: 231/548 - (42%)
• Gaps: 124/548 - (22%)

  Fly    11 AIAITIILISYVFLLLKCKQKAFVVIGLLYQEKKYQCFDQAPGPHPWPIIGNINLLGRFQYNPFY 75
            |:|: ::.:|.:|||...:|.:  ..|.|           ..||.|.||||||..|.....:.
Human     4 AVAL-VLCLSCLFLLSLWRQSS--GRGRL-----------PSGPTPLPIIGNILQLDVKDMSK-- 52

  Fly    76 GFGTLTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGRPDFFRYHKLFGGDRNNSLAL 140
            .....:|.||.::::..|....:|::..:.:||.|..:|:.|.||..|....|:     |..|.:
Human    53 SLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKV-----NKGLGI 112

  Fly   141 C-----DWSQLQQ------KRRNLARRHCSPRESSSYFSKMSEIGGLEVNQLLDQL--TNISSGY 192
            .     .|.::::      :...:.:|....|...            |...|:::|  ||.|
Human   113 LFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRVQE------------EARCLVEELRKTNAS--- 162

  Fly   193 PCDVKPLILAASANMFCQYMCSVRFNYSDKGFQKIIEYFDEIFWEINQGYSFDYIPWLVPFYCNH 257
            |||...::..|..|:.|..:...||:|.|:.|..::|.|:|....::.       ||:.  .||:
Human   163 PCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNENLRILSS-------PWIQ--VCNN 218

  Fly   258 ISRIVHW-----------SASIRKFILERIVNHRESNININEPDKDFTDALLKSLKEDKNVSRN- 310
            ...::.:           .|.|:.::||||..|:|| :::|.. :||.|..|..::::|:..::
Human   219 FPALIDYLPGSHNKIAENFAYIKSYVLERIKEHQES-LDMNSA-RDFIDCFLIKMEQEKHNQQSE 281

  Fly   311 ----TIIFMLEDFIG-GHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIRRICLYDMNVM 370
                ::|..:.|..| |.......:...|..:.|.|.:...::.|::.|..:. |..|:.|.:.|
Human   282 FTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRN-RSPCMQDRSHM 345

  Fly   371 PYTMASISEVLRYSS--SPIVPHVAMEDTVIKGFGVRKGTIVFIN-NYVLNMSESFWNHPEQFDP 432
            |||.|.:.|:.||..  ...:||....|...|.:.:.|||.:..: ..||:..:.|.| ||.|||
Human   346 PYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPN-PEMFDP 409

  Fly   433 ERFLENNFTNNKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQFLPFSVGK 497
            ..||                          |..|:.|...|                |:|||.||
Human   410 GHFL--------------------------DKSGNFKKSDY----------------FMPFSAGK 432

  Fly   498 RTCIGQSLVRGFGFLLLANIIQNYNVNS 525
            |.|:|:.|.|...||.|..|:||:|:.|
Human   433 RMCMGEGLARMELFLFLTTILQNFNLKS 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	p450	52..549	CDD:299894	129/507 (25%)
CYP2C18	NP_000763.1	p450	30..487	CDD:306555	129/508 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920