Protein Alignment spok and CYP2C9

DIOPT Version :9

• Sequence 1: NP_001104460.2
• Gene: spok / 5740359
• FlyBaseID: FBgn0086917
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_000762.2
• Gene: CYP2C9 / 1559
• HGNCID: 2623
• Length: 490
• Species: Homo sapiens
• Alignment Length: 503
• Identity: 135/503 - (26%)
• Similarity: 219/503 - (43%)
• Gaps: 102/503 - (20%)

  Fly    52 PGPHPWPIIGNINLLGRFQYNPFYGFGTLTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKY 116
            |||.|.|:||||..:|....:.  ....|:|.||.:::|..|....:|::..:.:||.|...|:.
Human    31 PGPTPLPVIGNILQIGIKDISK--SLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEE 93

  Fly   117 FGGR---PDFFRYHKLFGGDRNNSLALCDWSQLQQ------KRRNLARRHCSPRESSSYFSKMSE 172
            |.||   |...|.::.||...:|..   .|.::::      :...:.:|....|...
Human    94 FSGRGIFPLAERANRGFGIVFSNGK---KWKEIRRFSLMTLRNFGMGKRSIEDRVQE-------- 147

  Fly   173 IGGLEVNQLLDQLTNISSGYPCDVKPLILAASANMFCQYMCSVRFNYSDKGFQKIIEYFDEIFWE 237
                |...|:::|....:. |||...::..|..|:.|..:...||:|.|:.|..::|       :
Human   148 ----EARCLVEELRKTKAS-PCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLME-------K 200

  Fly   238 INQGYSFDYIPWLVPFYCNHISRIVHW-----------SASIRKFILERIVNHRESNININEPDK 291
            :|:.......||:.  .||:.|.|:.:           .|.::.:|||::..|:|| :::|.| :
Human   201 LNENIKILSSPWIQ--ICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQES-MDMNNP-Q 261

  Fly   292 DFTDA-LLKSLKEDKNVSRNTIIFMLED-----FIGGHSAVGNLVMLALAYIAKNPTIALHIRNE 350
            ||.|. |:|..||..|......|..||:     |..|.......:..||..:.|:|.:...::.|
Human   262 DFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEE 326

  Fly   351 VDTVSAKGIRRICLYDMNVMPYTMASISEVLRYSS--SPIVPHVAMEDTVIKGFGVRKGTIVFIN 413
            ::.|..:. |..|:.|.:.||||.|.:.||.||..  ...:||....|...:.:.:.|||.:.|:
Human   327 IERVIGRN-RSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILIS 390

  Fly   414 -NYVLNMSESFWNHPEQFDPERFLENNFTNNKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQN 477
             ..||:.::.|.| ||.|||..||                          |..|:.|..||
Human   391 LTSVLHDNKEFPN-PEMFDPHHFL--------------------------DEGGNFKKSKY---- 424

  Fly   478 LNNKLLKKSIPQFLPFSVGKRTCIGQSLVRGFGFLLLANIIQNYNVNS 525
                        |:|||.|||.|:|::|.....||.|.:|:||:|:.|
Human   425 ------------FMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKS 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	p450	52..549	CDD:299894	135/503 (27%)
CYP2C9	NP_000762.2	p450	30..487	CDD:306555	135/503 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920