Protein Alignment spok and CYP2B6

DIOPT Version :9

• Sequence 1: NP_001104460.2
• Gene: spok / 5740359
• FlyBaseID: FBgn0086917
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_000758.1
• Gene: CYP2B6 / 1555
• HGNCID: 2615
• Length: 491
• Species: Homo sapiens
• Alignment Length: 530
• Identity: 128/530 - (24%)
• Similarity: 219/530 - (41%)
• Gaps: 99/530 - (18%)

  Fly    52 PGPHPWPIIGNINLLGRFQYNPFYGFGTLTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKY 116
            |||.|.|::|  |||...:......|....:||||::::.||....:::..|:.|:|.|....:.
Human    32 PGPRPLPLLG--NLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEA 94

  Fly   117 FGGR------PDFFRYHKLFGGDRNNSLALCDWSQLQQKRRNLARRHCSPRESSSYFSKMSEIGG 175
            |.||      ..|||.:.:...:.|....|..:|....:...:.:|....|...
Human    95 FSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQE----------- 148

  Fly   176 LEVNQLLDQLTNISSGYPCDVKPLILAASANMFCQYMCSVRFNYSDKGFQKIIEYFDEIFWEINQ 240
             |...|:::|.. |.|...|...|..:.:||:.|..:...||:|.|:.|.|::..|.:.|..|:.
Human   149 -EAQCLIEELRK-SKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISS 211

  Fly   241 --GYSFDYIPWLVPFYCNHISRIVHWSASIRKFILERIVNHRESNININEPDKDFTDALLKSLKE 303
              |..|:.....:.::.....::......|..:|...:..|||: ::.:.| ||..|..|..:::
Human   212 VFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRET-LDPSAP-KDLIDTYLLHMEK 274

  Fly   304 DK----------NVSRNTIIFMLEDFIGGHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKG 358
            :|          |::.||    |..|..|.......:......:.|.|.:|..:..|::.|....
Human   275 EKSNAHSEFSHQNLNLNT----LSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPH 335

  Fly   359 IRRICLYDMNVMPYTMASISEVLRYSS-SPI-VPHVAMEDTVIKGFGVRKGTIVFINNYVLNMSE 421
             |...|:|...||||.|.|.|:.|:|. .|: |||:..:.|..:|:.:.|.|.||:.........
Human   336 -RPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDP 399

  Fly   422 SFWNHPEQFDPERFLENNFTNNKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKS 486
            .::..|:.|:|:.||:.|                          |:               |||:
Human   400 HYFEKPDAFNPDHFLDAN--------------------------GA---------------LKKT 423

  Fly   487 IPQFLPFSVGKRTCIGQSLVRGFGFLLLANIIQNYNVNSADFSKIKLEKSSIAL-PKKC------ 544
             ..|:|||:|||.|:|:.:.|...||....|:||:::.|      .:....|.| |::|
Human   424 -EAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMAS------PVAPEDIDLTPQECGVGKIP 481

  Fly   545 --FKLSLRPR 552
              :::...||
Human   482 PTYQIRFLPR 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	p450	52..549	CDD:299894	126/525 (24%)
CYP2B6	NP_000758.1	p450	42..488	CDD:278495	120/513 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920