Protein Alignment spok and CYP2A13

DIOPT Version :9

• Sequence 1: NP_001104460.2
• Gene: spok / 5740359
• FlyBaseID: FBgn0086917
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_000757.2
• Gene: CYP2A13 / 1553
• HGNCID: 2608
• Length: 494
• Species: Homo sapiens
• Alignment Length: 592
• Identity: 136/592 - (22%)
• Similarity: 228/592 - (38%)
• Gaps: 138/592 - (23%)

  Fly     1 MLTS-VFYVLFAIAITIILISYVFLLLKCKQKAFVVIGLLYQEKKYQCFDQAPGPHPWPIIGNIN 64
            ||.| :..|.....:|::::..|:...|.:.|.                  .|||.|.|.|||..
Human     1 MLASGLLLVTLLACLTVMVLMSVWRQRKSRGKL------------------PPGPTPLPFIGNYL 47

  Fly    65 LLGRFQ-YNPFYGFGTLTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGRPDFFRYHK 128
            .|...| ||...   .::::||.::::.||..|.:|:...|.:||.|....:.|.||.:...:..
Human    48 QLNTEQMYNSLM---KISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDW 109

  Fly   129 LFGGDRNNSLALCDWSQLQQKRR---------NLARRHCSPRESSSYFSKMSEIGGLEVNQLLDQ 184
            ||.|   ..:|..:..:.:|.||         .:.:|....|        :.|..|.    |:|.
Human   110 LFKG---YGVAFSNGERAKQLRRFSIATLRGFGVGKRGIEER--------IQEEAGF----LIDA 159

  Fly   185 LTNISSGYPCDVKPLILAASANMFCQYMCSVRFNYSDKGFQKIIEYFDEIFWEINQGYSFDYIPW 249
            |.. :.|...|....:....:|:....:...||:|.||.|..::......|
Human   160 LRG-THGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSF-------------- 209

  Fly   250 LVPFYCNHISRIVHWSASIRK------------------FILERIVNHRESNININEPDKDFTDA 296
              .|......::....:|:.|                  ||.:: |.|.:..::.|.| :||.|:
Human   210 --QFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKK-VEHNQRTLDPNSP-RDFIDS 270

  Fly   297 -LLKSLKEDKNVS-----RNTIIFMLEDFIGGHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVS 355
             |::..:|:||.:     :|.::..|..|..|...|...:......:.|:|.:...:..|:|.|.
Human   271 FLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVI 335

  Fly   356 AKGIRRICLYDMNVMPYTMASISEVLRYSSS-PI-VPHVAMEDTVIKGFGVRKGTIVFINNYVLN 418
            .|. |:....|...||||.|.|.|:.|:... |: :.|...:||..:.|.:.|||.||.....:.
Human   336 GKN-RQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVL 399

  Fly   419 MSESFWNHPEQFDPERFLENNFTNNKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLL 483
            ....|:::|..|:|:.||:                |:.:| :|:|
Human   400 RDPRFFSNPRDFNPQHFLD----------------KKGQF-KKSD-------------------- 427

  Fly   484 KKSIPQFLPFSVGKRTCIGQSLVRGFGFLLLANIIQNYNVNSADFSK---IKLEKSSIALPKKCF 545
                 .|:|||:|||.|.|:.|.|...||....|:||:...|....|   :..:....|...:.:
Human   428 -----AFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRNY 487

  Fly   546 KLSLRPR 552
            .:|..||
Human   488 TMSFLPR 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	p450	52..549	CDD:299894	125/535 (23%)
CYP2A13	NP_000757.2	p450	34..491	CDD:278495	125/536 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920