Protein Alignment spok and CYP2A6

DIOPT Version :10

• Sequence 1: NP_001104460.2
• Gene: spok / 5740359
• FlyBaseID: FBgn0086917
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_000753.3
• Gene: CYP2A6 / 1548
• HGNCID: 2610
• Length: 494
• Species: Homo sapiens
• Alignment Length: 345
• Identity: 66/345 - (19%)
• Similarity: 136/345 - (39%)
• Gaps: 64/345 - (18%)

  Fly   245 KDKEELEAEREKLIRTTKKLKDDLQNVKNELKMT----NEMKKTLEQEKMSLNSKTEHLQANMES 305
            ::|..|..||.|...::::.|..:|.:...:.:|    .:....|.:..::|  ...:||  ::.
Human    42 REKLHLCEERAKSYSSSREYKQAIQELVRCVALTRICYGDWHWKLAEAYVNL--AQGYLQ--LKG 102

  Fly   306 LNIEKEKIHEQLQEIVREREKVLIDNQNLSTD--KCQ------LNNRLMEI----ETSRNCIMTE 358
            |:::.::..|:.:||:....:....|:   ||  ||.      |...|:.:    :.|.|.|..|
Human   103 LSLQAKQHAEKAKEILANSIESPCHNK---TDIFKCSLELFYTLGRALLSLQKFKDASENLIKAE 164

  Fly   359 ---KEKIE--NLLK---MNEQKTQDLEKERQYYTMKTS-ELMDHLKEVSEQRDLTESELK---EQ 411
               ||.::  |::|   :..|....|...:.|...|.| |.....::..|..::|:.|..   .|
Human   165 RLSKEMLQCGNIVKEEWIEIQSRIKLSFAQLYQGQKRSKEAFPFYQKALEYTEITKDEKSLECVQ 229

  Fly   412 MMARL-GAEKQLQAAEKALEHLEMALKMTGAQMTELQEHIMPDVHKLREFFEQCAEESRF---EA 472
            ::..| |.|:.|.....|:.|      .:.|.:..|.:...|         |:.|:.:.|   .|
Human   230 VLRELAGVEQALGLYAAAISH------FSRAHLIILSKDPSP---------EEAADSAHFIARAA 279

  Fly   473 NRTGIMRNAVYARKSIFDVAFSELDGHS------LDVFEKFCEYNSQVLPVREKPQKLHKTWKQS 531
            ..:|:..:...|.|...:...|..|...      |.:.::||.:    |....:.::.....::|
Human   280 AASGMHDHRDVAEKYFQESMTSIKDSEGAERAKFLSIQDEFCSF----LQTTGQKERAAMILRES 340

  Fly   532 SFKRIGSIRRSKRGIRSSFR 551
            ...::|:.......:..::|
Human   341 LEAKVGAFGDFSPEVAETYR 360

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	CYP1_2-like	85..547	CDD:410710	65/339 (19%)
CYP2A6	NP_000753.3	CYP2A	65..489	CDD:410761	60/322 (19%)