Protein Alignment spok and CYP1B1

DIOPT Version :9

• Sequence 1: NP_001104460.2
• Gene: spok / 5740359
• FlyBaseID: FBgn0086917
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_000095.2
• Gene: CYP1B1 / 1545
• HGNCID: 2597
• Length: 543
• Species: Homo sapiens
• Alignment Length: 565
• Identity: 138/565 - (24%)
• Similarity: 241/565 - (42%)
• Gaps: 90/565 - (15%)

  Fly    19 ISYVFLLLKCKQKAFVVIG-LLYQEKKYQCFDQAPGPHPWPIIGNINLLGRFQYNPFYGFGTLTK 82
            |....|||.....|.|.:| .|.::::.|.....|||..||:|||...:|:..:   ..|..|.:
Human    18 IQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLIGNAAAVGQAAH---LSFARLAR 79

  Fly    83 KYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGRPDFFRYHKLFGGDRNNSLALCDWSQ-- 145
            :|||::.:.||....:|:|....|.:.|.:.|..|..||.|..:..:.||   .|:|...:|:
Human    80 RYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGG---RSMAFGHYSEHW 141

  Fly   146 -LQQKRRNLARRHCSPRESSS-------YFSKMSEIGGLEVNQLLDQLTNISSGYPCDVKPLILA 202
             :|::..:...|:...|:..|       ..|:..|:..|.|....|       |...|.:||.:.
Human   142 KVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSAD-------GAFLDPRPLTVV 199

  Fly   203 ASANMFCQYMCSVRFNYSDKGFQKIIEYFDEIFWEINQGYSFDYIPWLVPFYCNHISRIV----H 263
            |.||:........|:::.|..|::::.:.:|....:..|...|.:||| .::.|.:..:.    .
Human   200 AVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVMPWL-QYFPNPVRTVFREFEQ 263

  Fly   264 WSASIRKFILERIVNHRESNININEPDKDFTDALLKSLKEDKNVS------------RNTIIFML 316
            .:.:...|||::.:.|.|| :......:|..||.:  |..:|..:            .|....:.
Human   264 LNRNFSNFILDKFLRHCES-LRPGAAPRDMMDAFI--LSAEKKAAGDSHGGGARLDLENVPATIT 325

  Fly   317 EDFIGGHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIRRICLYDMNVMPYTMASISEVL 381
            :.|......:...:...|....:.|.:...::.|:|.|..:. |..|:.|...:||.:|.:.|.:
Human   326 DIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRD-RLPCMGDQPNLPYVLAFLYEAM 389

  Fly   382 RYSS-SPI-VPHVAMEDTVIKGFGVRKGTIVFINNYVLNMSESFWNHPEQFDPERFLENNFTNNK 444
            |:|| .|: :||....:|.:.|:.:.|.|:||:|.:.:|.....|.:||.|||.|||
Human   390 RFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFL-------- 446

  Fly   445 ESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQFLPFSVGKRTCIGQSLVRGF 509
                              |.||           |.||.|...:   :.||||||.|||:.|.:..
Human   447 ------------------DKDG-----------LINKDLTSRV---MIFSVGKRRCIGEELSKMQ 479

  Fly   510 GFLLLANIIQ--NYNVNSADFSKIKLEKSSIALPKKCFKLSLRPR 552
            .||.::.:..  ::..|..:.:|:.. ...:.:..|.||:::..|
Human   480 LFLFISILAHQCDFRANPNEPAKMNF-SYGLTIKPKSFKVNVTLR 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	p450	52..549	CDD:299894	128/526 (24%)
CYP1B1	NP_000095.2	p450	51..520	CDD:365848	128/527 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	1	1.010	-	-		D278622at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.930