Protein Alignment spok and CYP1A2

DIOPT Version :9

• Sequence 1: NP_001104460.2
• Gene: spok / 5740359
• FlyBaseID: FBgn0086917
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_000752.2
• Gene: CYP1A2 / 1544
• HGNCID: 2596
• Length: 516
• Species: Homo sapiens
• Alignment Length: 541
• Identity: 139/541 - (25%)
• Similarity: 230/541 - (42%)
• Gaps: 80/541 - (14%)

  Fly    13 AITIILISYVFLLLKCKQKAFVVIGLLYQEKKYQCFDQAPGPHPWPIIGNINLLGRFQYNPFYGF 77
            |..::|.|.:|.|:     .:|:.||  :.:..:.....|.|..||::|::..||:   ||....
Human    11 ATELLLASAIFCLV-----FWVLKGL--RPRVPKGLKSPPEPWGWPLLGHVLTLGK---NPHLAL 65

  Fly    78 GTLTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGRPDFFRYHKLFGGDRNNSLAL-C 141
            ..::::|||:..:.:|.|..:|::.:|.|::.|.:.|..|.||||.:....:..|   .||.. .
Human    66 SRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG---QSLTFST 127

  Fly   142 DWSQLQQKRRNLARRHCS-------PRESSSYFSKMSEIGGLEVNQLLDQLTNISSGYPCDVKPL 199
            |...:...||.||:...:       |..|||.:  :.|....|...|:.:|..:.:| |....|.
Human   128 DSGPVWAARRRLAQNALNTFSIASDPASSSSCY--LEEHVSKEAKALISRLQELMAG-PGHFDPY 189

  Fly   200 --ILAASANMFCQYMCSVRFNYSDKGFQKIIEYFDEIFWEINQGYSFDYIPWLVPFYCNHISRIV 262
              ::.:.||:.........|..|......:::...|.....:.|...|:.| ::.:..|  ..:.
Human   190 NQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP-ILRYLPN--PALQ 251

  Fly   263 HWSASIRKFI--LERIVNHRESNININEPDKDFTDALLKSLKEDKNVSRN-----TIIFMLEDFI 320
            .:.|..::|:  |::.|.....:.:.|.. :|.|.||.|..|:....|.|     .|:.::.|..
Human   252 RFKAFNQRFLWFLQKTVQEHYQDFDKNSV-RDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIF 315

  Fly   321 G-GHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIRRICLYDMNVMPYTMASISEVLRYS 384
            | |...|...:..:|.|:...|.|...|:.|:|||..:. ||..|.|...:||..|.|.|..|:|
Human   316 GAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRE-RRPRLSDRPQLPYLEAFILETFRHS 379

  Fly   385 S-SPI-VPHVAMEDTVIKGFGVRKGTIVFINNYVLNMSESFWNHPEQFDPERFLENNFTNNKESG 447
            | .|. :||....||.:.||.:.|...||:|.:.:|.....|..|.:|.|||||
Human   380 SFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFL----------- 433

  Fly   448 LKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQFLPFSVGKRTCIGQSLVRGFGFL 512
                           ..||:.         :|..|.:|    .:.|.:|||.|||:.|.:...||
Human   434 ---------------TADGTA---------INKPLSEK----MMLFGMGKRRCIGEVLAKWEIFL 470

  Fly   513 LLANIIQNYNVNSADFSKIKL 533
            .||.::|....:.....|:.|
Human   471 FLAILLQQLEFSVPPGVKVDL 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	p450	52..549	CDD:299894	131/502 (26%)
CYP1A2	NP_000752.2	p450	42..500	CDD:365848	131/503 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920