DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spok and Cyp2f2

DIOPT Version :9

Sequence 1:	NP_001104460.2	Gene:	spok / 5740359	FlyBaseID:	FBgn0086917	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_031843.2	Gene:	Cyp2f2 / 13107	MGIID:	88608	Length:	491	Species:	Mus musculus

Alignment Length:	577	Identity:	149/577 - (25%)
Similarity:	241/577 - (41%)	Gaps:	129/577 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 AITIILISYVFLLLKCKQKAFVVIGLLYQEKKYQCFDQAPGPHPWPIIGNINLLGRFQYNPFYGF 77
            ||.::|::.:.|.|....:.           |.|.   .|||.|.||:|  |||.....:.....
Mouse     7 AILLLLLAVISLSLTFSSRG-----------KGQL---PPGPKPLPILG--NLLQLRSQDLLTSL 55

  Fly    78 GTLTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGR---PDFFRYHKLFGGDRNNSLA 139
            ..|:|:||.::::.||....||::....:||.|...|:.|.||   |.||.:      .|.|.:|
Mouse    56 TKLSKEYGSVFTVYLGSRPVIVLSGYQTVKEALVDKGEEFSGRGAYPVFFNF------TRGNGIA 114

  Fly   140 LCD---WSQLQ----QKRRN--LARRHCSPR--ESSSYFSKMSEIGGLEVNQLLDQLTNISSGYP 193
            ..|   |..|:    |..||  :.:|....|  |..|:.        |||.:.::       |.|
Mouse   115 FSDGERWKILRRFSVQILRNFGMGKRSIEERILEEGSFL--------LEVLRKME-------GKP 164

  Fly   194 CDVKPLILAASANMFCQYMCSVRFNYSDKGFQKIIEYFDEIFWEINQGYSFDYIPWLVPFYCNHI 258
            .|...::..:.:|:.|..:...||:|.|:....||.:       ||..:.....||...:  |..
Mouse   165 FDPVFILSRSVSNIICSVVFGSRFDYDDERLLTIIHF-------INDNFKIMSSPWGEMY--NIF 220

  Fly   259 SRIVHW-----SASIRKF-----ILERIVNHRESNININEPDKDFTDALLKSLKEDK-----NVS 308
            ..::.|     ....|.|     ::.|.|...:.:::.|.| :||.|..|..:.::|     :.:
Mouse   221 PSVLDWIPGPHKRLFRNFGGMKDLIARSVREHQDSLDPNSP-RDFIDCFLTKMAQEKQDPLSHFN 284

  Fly   309 RNTIIFMLEDFI-GGHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIRRICLYDMNVMPY 372
            .:|::....:.: ||...||..:..|...:.|.|.:...::.|:|.|..:. |...|.|...|||
Mouse   285 MDTLLMTTHNLLFGGTETVGTTLRHAFLILMKYPKVQARVQEEIDRVVGRS-RMPTLEDRTSMPY 348

  Fly   373 TMASISEVLRYSS-SPI-VPHVAMEDTVIKGFGVRKGT-IVFINNYVLNMSESFWNHPEQFDPER 434
            |.|.|.||.|::. .|: :||....||..:||.:.||| ::.:.|.|...|:.| ..|::|:||.
Mouse   349 TDAVIHEVQRFADVIPMNLPHRVTRDTPFRGFLIPKGTDVITLLNTVHYDSDQF-KTPQEFNPEH 412

  Fly   435 FLENNFTNNKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQFLPFSVGKRT 499
            ||::|.:                                         .||| |.|:|||.|:|.
Mouse   413 FLDDNHS-----------------------------------------FKKS-PAFMPFSAGRRL 435

  Fly   500 CIGQSLVRGFGFLLLANIIQNYN----VNSADFSKIKLEKSSIALPKKCFKLSLRPR 552
            |:|:.|.|...|:...:|:||:.    |:..|.....|......||:. |:|.:..|
Mouse   436 CLGEPLARMELFIYFTSILQNFTLQPLVDPEDIDLTPLSSGLGNLPRP-FQLCMHIR 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	p450	52..549	CDD:299894	141/533 (26%)
Cyp2f2	NP_031843.2	p450	31..488	CDD:278495	141/534 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920