Protein Alignment spok and Cyp2e1

DIOPT Version :9

• Sequence 1: NP_001104460.2
• Gene: spok / 5740359
• FlyBaseID: FBgn0086917
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_067257.1
• Gene: Cyp2e1 / 13106
• MGIID: 88607
• Length: 493
• Species: Mus musculus
• Alignment Length: 584
• Identity: 153/584 - (26%)
• Similarity: 250/584 - (42%)
• Gaps: 136/584 - (23%)

  Fly    12 IAITIILISYVFLLLKCKQKAFVVIGLLYQEKKYQCFDQAPGPHPWPIIGNINLLGRFQYN---- 72
            :.||:.|:.::..||        ::.:..|  .|:.::..|||.|.|..|||     ||.:
Mouse     4 LGITVALLVWIATLL--------LVSIWKQ--IYRSWNLPPGPFPIPFFGNI-----FQLDLKDI 53

  Fly    73 PFYGFGTLTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGRPDF--FRYHKLFGGDRN 135
            | .....|.|::|.:::|.||..|.:|::....:||||..:...|.||.|.  |:.:|..|...|
Mouse    54 P-KSLTKLAKRFGPVFTLHLGQRRIVVLHGYKAVKEVLLNHKNEFSGRGDIPVFQEYKNKGIIFN 117

  Fly   136 N----------SLA-LCDWSQLQQKRRNLARRHCSPRESSSYFSKMSEIGGLEVNQLLDQLTNIS 189
            |          ||: |.||...:|......:|                    |.:.|:::|.. :
Mouse   118 NGPTWKDVRRFSLSILRDWGMGKQGNEARIQR--------------------EAHFLVEELKK-T 161

  Fly   190 SGYPCDVKPLILAASANMFCQYMCSVRFNYSDKGFQKIIEYFDEIFWEIN----QGYSF--DYIP 248
            .|.|.|...||..|..|:....:.:.||:|.||...:::..|:|.|:.::    |.|::  ||:.
Mouse   162 KGQPFDPTFLIGCAPCNVIADILFNKRFDYDDKKCLELMSLFNENFYLLSTPWIQAYNYFSDYLQ 226

  Fly   249 WLVPFYCNHISRIVHWSASIRKFILERIVNHRESNININEPDKDFTDALLKSLKEDKN------V 307
            :|...:    .:::...:.||::.|.:...|.:| ::||.| :|.||.||..::::|:      .
Mouse   227 YLPGSH----RKVMKNVSEIRQYTLGKAKEHLKS-LDINCP-RDVTDCLLIEMEKEKHSQEPMYT 285

  Fly   308 SRNTIIFMLEDFIGGHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIRRICLYDMNVMPY 372
            ..|..:.:.:.|..|.......:...|..:.|.|.|...:..|:|.|.... |...:.|...|||
Mouse   286 MENISVTLADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPS-RAPAVRDRMNMPY 349

  Fly   373 TMASISEVLRYSS--SPIVPHVAMEDTVIKGFGVRKGTIV-------FINNYVLNMSESFWNHPE 428
            ..|.:.|:.|:.:  ...:||.|..|||.:|:.:.|||:|       ..:||.       :..||
Mouse   350 MDAVVHEIQRFINLVPSNLPHEATRDTVFRGYVIPKGTVVIPTLDSLLFDNYE-------FPDPE 407

  Fly   429 QFDPERFLENNFTNNKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQFLPF 493
            .|.||.||..|                          |..|...|                |..|
Mouse   408 TFKPEHFLNEN--------------------------GKFKYSDY----------------FKAF 430

  Fly   494 SVGKRTCIGQSLVRGFGFLLLANIIQNYNVNS-ADFSKIKLEKSSI---ALPKKCFKLSLRPRT 553
            |.|||.|:|:.|.|...||||:.|:|::|:.| .|...|.|...:|   ::|:: |||.:.||:
Mouse   431 SAGKRVCVGEGLARMELFLLLSAILQHFNLKSLVDPKDIDLSPVTIGFGSIPRE-FKLCVIPRS 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	p450	52..549	CDD:299894	144/538 (27%)
Cyp2e1	NP_067257.1	p450	44..489	CDD:278495	138/528 (26%)
		Substrate binding. /evidence=ECO:0000250	298..303		1/4 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010