DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spok and Cyp2d9

DIOPT Version :9

Sequence 1:	NP_001104460.2	Gene:	spok / 5740359	FlyBaseID:	FBgn0086917	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_034136.2	Gene:	Cyp2d9 / 13105	MGIID:	88606	Length:	504	Species:	Mus musculus

Alignment Length:	540	Identity:	121/540 - (22%)
Similarity:	227/540 - (42%)	Gaps:	106/540 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 IILISYVFLLLKCKQKAFVVIGLLYQEKKYQCFDQAPGPHPWPIIGNINL--LGRFQYNPFYGFG 78
            :.:.:.:|:||         :.|.:|.:::.. ...|||.|||::||:..  ||...|:.:
Mouse    12 VAIFTVIFILL---------VDLTHQRQRWTS-RYPPGPVPWPVLGNLLQVDLGNMPYSLY---- 62

  Fly    79 TLTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGRP--DFFRYHKLFGGDRNNSLALC 141
            .|..:|||::||.:.....:|:|.:..:||:|...|:....||  ..|.|..:..|.:...||..
Mouse    63 KLQNRYGDVFSLQMAWKPMVVINGLKAMKEMLLTCGEDTADRPPVPIFEYLGVKPGSQGVVLAPY 127

  Fly   142 DWSQLQQKR------RNLARRHCSPRESSSYFSKMSEIGGLEVNQLLDQLTNISSGYPCDVKPLI 200
            .....:|:|      ||..   ...:....:.:|       |.|.|.|..| ..:|.|.:..|::
Mouse   128 GPEWREQRRFSVSTLRNFG---LGKKSLEDWVTK-------EANHLCDAFT-AQAGQPINPNPML 181

  Fly   201 LAASANMFCQYMCSVRFNYSDKGFQKIIEYFDEIFWEINQGYSFDYIPWLVPFYCN------HIS 259
            ..::.|:....:.:.||.|.|....::::..::...|::         .|:|...|      .|.
Mouse   182 NKSTCNVIASLIFARRFEYEDPFLIRMLKVLEQSLTEVS---------GLIPEVLNAFPILLRIP 237

  Fly   260 RIVHWSASIRK---FILERIVNHRESNININEPDKDFTDALLKSLKEDK-----NVSRNTIIFML 316
            |:...:...:|   .||:.::....:..:..:..::.|||.|..:::.|     :.:...::.::
Mouse   238 RLADKALQGQKSFIAILDNLLTENRTTWDPVQAPRNLTDAFLAEIEKAKGNPESSFNDENLLMVV 302

  Fly   317 EDFIG-GHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIRRICLYDMNVMPYTMASISEV 380
            .|..| |.......:..||..:..:|.:...::.|:|.|..: :|...:.|...||||.|.|.||
Mouse   303 RDLFGAGMLTTSTTLSWALMLMILHPDVQRRVQQEIDEVIGQ-VRHPEMADQAHMPYTNAVIHEV 366

  Fly   381 LRYSS-SPI-VPHVAMEDTVIKGFGVRKGTIVFINNYVLNMSESFWNHPEQFDPERFLENNFTNN 443
            .|:.. .|: :|.:...|..::.|.:.||||:..|...:...||.|..|.:|.||.||:
Mouse   367 QRFGDIVPVNLPRITSHDIEVQDFLIPKGTILLPNMSSMLKDESVWEKPLRFHPEHFLD------ 425

  Fly   444 KESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQ-FLPFSVGKRTCIGQSLVR 507
                      .:..|::                           |: |:|||.|:|:|:|::|.|
Mouse   426 ----------AQGHFVK---------------------------PEAFMPFSAGRRSCLGEALAR 453

  Fly   508 GFGFLLLANIIQNYNVNSAD 527
            ...||....::|.::.:..|
Mouse   454 MELFLFFTCLLQRFSFSVPD 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	p450	52..549	CDD:299894	116/504 (23%)
Cyp2d9	NP_034136.2	p450	37..496	CDD:278495	116/505 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920