Protein Alignment spok and Cyp2c40

DIOPT Version :10

• Sequence 1: NP_001104460.2
• Gene: spok / 5740359
• FlyBaseID: FBgn0086917
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_034134.3
• Gene: Cyp2c40 / 13099
• MGIID: 1306815
• Length: 491
• Species: Mus musculus
• Alignment Length: 550
• Identity: 152/550 - (27%)
• Similarity: 241/550 - (43%)
• Gaps: 113/550 - (20%)

  Fly    21 YVFLLLKCKQKAFVVIGLLYQEKKYQCFDQAPGPHPWPIIGNINL-----LGRFQYNPFYGFGTL 80
            :|.|:| |  .:|:::..|::::..: .:..|||.|.|||||.:|     :|:...|       .
Mouse     4 FVVLVL-C--LSFLLVLSLWRQRSAR-GNLPPGPTPLPIIGNYHLIDMKDIGQCLTN-------F 57

  Fly    81 TKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGR---PDFFRYH--KLFGGDRNNSLAL 140
            :|.||.:::|..|....:|::..:.|||.|..:|:.|.||   |.|.:..  |..|....|.
Mouse    58 SKTYGPVFTLYFGSQPIVVLHGYEAIKEALIDHGEEFSGRGRIPVFDKVSTGKGIGFSHGNV--- 119

  Fly   141 CDWSQLQQKRRNLARRHCSPRESSSYFSKMSEIGGLEVNQLLDQLTNISSGYPCDVKPLILAASA 205
              |...:....|..|.....:.:..  :|:.|    |...|:.:|.. ::|.|||.:.:|..|..
Mouse   120 --WKATRVFTVNTLRNLGMGKRTIE--NKVQE----EAQWLMKELKK-TNGSPCDPQFIIGCAPC 175

  Fly   206 NMFCQYMCSVRFNYSDKGFQKIIEYFDEIFWEI--NQGYS-FDYIPWLVPFYC----NHISRIVH 263
            |:.|..:...||:|.||.|..:|...:|. .||  :.|.. |:.:|.|:. ||    |.:.:...
Mouse   176 NVICSIVFQNRFDYKDKDFLSLIGKVNEC-TEILSSPGCQIFNAVPILID-YCPGSHNKLFKNHT 238

  Fly   264 WSASIRKFILERIVNHRESNININEPDKDFTDALLKSLKEDKNVSR-----NTIIFMLEDFI-GG 322
            |   |:.::|.:|..|.|| :::..| :||.|..|...::...:..     ..:..::.|.: ||
Mouse   239 W---IKSYLLGKIKEHEES-LDVTNP-RDFIDYFLIQRRQKNGIEHMDYTIEHLATLVTDLVFGG 298

  Fly   323 HSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIRRICLYDMNVMPYTMASISEVLRY-SSS 386
            ...:.:.:..||..:.|:..|...::.|:|.|..:. |..|:.|.|.||||.|.:.||.|| ...
Mouse   299 TETLSSTMRFALLLLMKHTHITAKVQEEIDNVIGRH-RSPCMQDRNHMPYTNAMVHEVQRYIDLG 362

  Fly   387 PI-VPHVAMEDTVIKGFGVRKGTIVFIN-NYVLNMSESFWNHPEQFDPERFLENNFTNNKESGLK 449
            |. |.|....||..:.:.:.|||.|..: ..||:.|..|.| ||.|||..||::|
Mouse   363 PNGVVHEVTCDTKFRNYFIPKGTQVMTSLTSVLHDSTEFPN-PEVFDPGHFLDDN---------- 416

  Fly   450 CDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQFLPFSVGKRTCIGQSLVRGFGFLLL 514
                            |:.|...|                |:|||.|||.|:|:||.|...||.|
Mouse   417 ----------------GNFKKSDY----------------FVPFSAGKRICVGESLARMELFLFL 449

  Fly   515 ANIIQNYNV-------------NSADFSKI 531
            ..|:||:.:             ..:.||||
Mouse   450 TTILQNFKLKPLVDPKDIDMTPKHSGFSKI 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	CYP1_2-like	85..547	CDD:410710	131/480 (27%)
Cyp2c40	NP_034134.3	CYP2C-like	61..485	CDD:410758	132/481 (27%)