DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spok and Cyp2c39

DIOPT Version :9

Sequence 1:	NP_001104460.2	Gene:	spok / 5740359	FlyBaseID:	FBgn0086917	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001360866.1	Gene:	Cyp2c39 / 13098	MGIID:	1306818	Length:	490	Species:	Mus musculus

Alignment Length:	579	Identity:	151/579 - (26%)
Similarity:	242/579 - (41%)	Gaps:	130/579 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IAITIILISYVFLLLKCKQKAFVVIGLLYQEKKYQCFDQAPGPHPWPIIGN-INLLGRFQYNPFY 75
            |...::.:|.:.|||..:|::  ..|.|           .|||.|:||||| :.:.|:   |...
Mouse     4 ITFLVLTLSSLILLLLWRQRS--GRGRL-----------PPGPTPFPIIGNFLQIDGK---NFSQ 52

  Fly    76 GFGTLTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGRPDFFRYHKLFGGDRNNSLAL 140
            .....:|.||.:::|.||....:|::..:.:||.|..:|:.|..|.......|:     ||.|.:
Mouse    53 SLTNFSKAYGPVFTLYLGSRPTVVLHGYEAVKEALIDHGEEFSDRGSIPMVEKI-----NNGLGI 112

  Fly   141 C-----DWSQLQQ----KRRNL--ARRHCSPRESSSYFSKMSEIGGLEVNQLLDQLTNISSGYPC 194
            .     .|.::::    ..|||  .:|:...|...            |...|:::|.. :.|.||
Mouse   113 VFSNGNRWKEIRRFTLTTLRNLGMGKRNIEDRVQE------------EAQCLVEELRK-TKGSPC 164

  Fly   195 DVKPLILAASANMFCQYMCSVRFNYSDKGFQKIIEYFDEIFWEINQGYSFDYIPWLVPFYCNHIS 259
            |...::..|..|:.|..:...||:|.||.|..::|       ::|:.......|||.  .||:..
Mouse   165 DPTFILSCAPCNVICSIIFQDRFDYKDKDFLMLME-------KLNENVKILSSPWLQ--VCNNFP 220

  Fly   260 RIVHWSAS-----------IRKFILERIVNHRESNININEPDKDFTDALLKSLKEDKNVSRNTII 313
            .::.:...           ||.::||:|..|:|| :::..| :||.|..|...|:..::.:..
Mouse   221 LLIDYCPGSHHKVLKNVKYIRSYLLEKIKEHQES-LDVTNP-RDFIDYYLIKQKQANHIQQAE-- 281

  Fly   314 FMLED--------FIGGHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIRRICLYDMNVM 370
            |.||:        |..|.......:..||..:.|.|.:...::.|:|.|..:. |..|:.|.|.|
Mouse   282 FSLENLACTINNLFAAGTETTSTTLRYALLLLMKYPDVTAKVQEEIDHVIGRH-RSPCMQDRNHM 345

  Fly   371 PYTMASISEVLRYSS--SPIVPHVAMEDTVIKGFGVRKGTIVFIN-NYVLNMSESFWNHPEQFDP 432
            |||.|.|.||.|:.:  ...:|.....|...:.:.:.|||.|..: ..||:.|:.|.| ||.|||
Mouse   346 PYTDAMIHEVQRFINLVPNNIPRAVTCDIKFRNYLIPKGTTVVTSLTSVLHDSKEFPN-PELFDP 409

  Fly   433 ERFLENNFTNNKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQFLPFSVGK 497
            ..||:.|..                 .:|:|:                         |:|||.||
Mouse   410 GHFLDANGN-----------------FKKSDH-------------------------FMPFSAGK 432

  Fly   498 RTCIGQSLVRGFGFLLLANIIQNYNVNS----ADFSKIKLEKSSIALPKKCFKLSLRPR 552
            |.|.|:.|.|...||.|..|:||:.:.|    .|...|......||||.. :::.:.||
Mouse   433 RVCAGEGLARMELFLFLTTILQNFKLKSLVHPKDIDMIPFVNGLIALPPH-YQVCIIPR 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	p450	52..549	CDD:299894	141/534 (26%)
Cyp2c39	NP_001360866.1	p450	30..487	CDD:365848	141/535 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920