DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spok and Cyp2c38

DIOPT Version :9

Sequence 1:	NP_001104460.2	Gene:	spok / 5740359	FlyBaseID:	FBgn0086917	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_034132.2	Gene:	Cyp2c38 / 13097	MGIID:	1306819	Length:	490	Species:	Mus musculus

Alignment Length:	566	Identity:	143/566 - (25%)
Similarity:	235/566 - (41%)	Gaps:	119/566 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LISYVFLLLKCKQKAFVVIGLLYQEKKYQCFDQAPGPHPWPIIGNINLLGRFQYNPFYGFGTLTK 82
            |::::.|.|    .:.:::.|..|..:....  .|||.|:|||||...:....:|  ......:|
Mouse     3 LVTFLVLTL----SSLILLSLWRQRSRRGRL--PPGPTPFPIIGNFLQIDVKNFN--QSLTNFSK 59

  Fly    83 KYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGRPDFFRYHKLFGGDRNNSLALC-----D 142
            .||.:::|.||....:|::..:.:||.|..:|:.|.||.:.....|:     ||.|.:.     .
Mouse    60 TYGPVFTLYLGSRPIVVLHGYEAVKEALIDHGEEFSGRENIPMSEKI-----NNGLGITFSNGNS 119

  Fly   143 WSQLQQ----KRRNL--ARRHCSPRESSSYFSKMSEIGGLEVNQLLDQLTNISSGYPCDVKPLIL 201
            |.:.::    ..|||  .:|:...|...            |...|:::|.. :.|.|||...::.
Mouse   120 WKETRRFTLMTLRNLGMGKRNIEDRVRE------------EAQCLVEELRK-TKGSPCDPTFILS 171

  Fly   202 AASANMFCQYMCSVRFNYSDKGFQKIIEYFDEIFWEINQGYSFDYIPWLVPFYCNHISRIVHWSA 266
            .|..|:.|..:...||:|.||.|..:::       ::|:.......|||.  .||:...::.:..
Mouse   172 CAPCNVICSIIFQDRFDYKDKDFLMLMK-------KLNENVKILSSPWLQ--VCNNFPLLIDYCP 227

  Fly   267 S-----------IRKFILERIVNHRESNININEPDKDFTDALLKSLKEDKNVSR------NTIIF 314
            .           ||.::||::..|:|| :::..| :||.|..|...|:..::.:      |.:..
Mouse   228 GSHHKVLKNFKYIRSYLLEKVKEHQES-LDVTNP-RDFIDYFLIKQKQANHIEQAEYSLENLVCT 290

  Fly   315 MLEDFIGGHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIRRICLYDMNVMPYTMASISE 379
            :...|..|.......:..||..:.|.|.:...::.|:|.|..:. |..|:.|.:.||||.|.|.|
Mouse   291 INNLFAAGTETTSTTLRYALLLLMKYPDVTAKVQEEIDHVVGRH-RSPCMQDRSRMPYTDAMIHE 354

  Fly   380 VLRYSS--SPIVPHVAMEDTVIKGFGVRKGTIVFIN-NYVLNMSESFWNHPEQFDPERFLENNFT 441
            |.|:.:  ...:||....|...:.:.:.|||.|..: ..||:.|:.|.| ||.|||..||:.|
Mouse   355 VQRFINLVPNNLPHAVTCDIKFRNYIIPKGTTVVTSLTSVLHDSKEFPN-PEMFDPGHFLDAN-- 416

  Fly   442 NNKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQFLPFSVGKRTCIGQSLV 506
                                    |:.|...|                |:.||.|||.|.|:.|.
Mouse   417 ------------------------GNFKKSDY----------------FMTFSAGKRVCAGEGLA 441

  Fly   507 RGFGFLLLANIIQNYNVNS----ADFSKIKLEKSSIALP---KKCF 545
            |...||:|..|:||:.:.|    .|...|......|.||   :.||
Mouse   442 RMELFLILTTILQNFKLKSLVHPKDIDMIPFVNGLITLPPHYQLCF 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	p450	52..549	CDD:299894	138/532 (26%)
Cyp2c38	NP_034132.2	p450	30..487	CDD:278495	136/531 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920