DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spok and Cyp2b10

DIOPT Version :9

Sequence 1:	NP_001104460.2	Gene:	spok / 5740359	FlyBaseID:	FBgn0086917	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_034129.1	Gene:	Cyp2b10 / 13088	MGIID:	88598	Length:	491	Species:	Mus musculus

Alignment Length:	541	Identity:	143/541 - (26%)
Similarity:	235/541 - (43%)	Gaps:	107/541 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VLFAIAITIILISYVFLLLKCKQKA---FVVIGLLYQEKKYQCFDQAPGPHPWPIIGNINLLGRF 69
            ||..:|   :|:.::.||.:...|:   |                 .|||.|.|::|  |||...
Mouse     5 VLLLLA---LLVGFLLLLARGHPKSRGNF-----------------PPGPRPLPLLG--NLLQMD 47

  Fly    70 QYNPFYGFGTLTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGR-------PDFFRYH 127
            :......|..|.:||||::::.||....:::...|.|:|.|....:.|.||       |.|..|.
Mouse    48 RGGLLKSFIQLREKYGDVFTVHLGPRPVVMLCGTDTIREALVGQAEAFSGRGTVAVVEPTFKEYG 112

  Fly   128 KLF-GGDRNNSLALCDWSQLQQKRRNLARRHCSPRESSSYFSKMSEIGGLEVNQLLDQLTNISSG 191
            .:| .|:|        |..|  :|.:||..........|...::.|    |...|:::|.. |.|
Mouse   113 VIFANGER--------WKTL--RRFSLATMRDFGMGKRSVEERIQE----EAQCLVEELRK-SQG 162

  Fly   192 YPCDVKPLILAASANMFCQYMCSVRFNYSDKGFQKIIEYFDEIFWEINQGYS--FDYIPWLVPFY 254
            .|.|...|....:||:.|..:...||.|:|:.|.:::|.|.:.|..|:...|  |:.....:.::
Mouse   163 APLDPTFLFQCITANIICSIVFGERFEYTDRQFLRLLELFYQTFSLISSFSSQMFELFSGFLKYF 227

  Fly   255 CNHISRIVHWSASIRKFILERIVNHRESNININEPDKDFTDALLKSLKEDKNVS------RNTII 313
            .....:|......:..:|...:..|| :.::.:.| :||.|..|..::::|:..      :|.::
Mouse   228 PGAHRQISKNLQELLDYIGHSVEKHR-ATLDPSVP-RDFIDIYLLRMEKEKSNQHTEFHHQNLMM 290

  Fly   314 FMLEDFIGGHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIRRI-CLYDMNVMPYTMASI 377
            .:|..|..|.......:......:.|.|.:|..::.|:|.|.  |..|: .|.|...||||.|.|
Mouse   291 SVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVI--GSHRLPTLDDRTKMPYTDAVI 353

  Fly   378 SEVLRYSS-SPI-VPHVAMEDTVIKGFGVRKGTIVF-INNYVLNMSESFWNHPEQFDPERFLENN 439
            .|:.|:|. .|| |||...:||:.:|:.:.|.|.|: |.:..|: ...::..|:.|:|:.||:.|
Mouse   354 HEIQRFSDLIPIGVPHRVTKDTMFRGYLLPKNTEVYPILSSALH-DPQYFEQPDSFNPDHFLDAN 417

  Fly   440 FTNNKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQFLPFSVGKRTCIGQS 504
                                      |:               |||| ..|||||.|||.|:|:|
Mouse   418 --------------------------GA---------------LKKS-EAFLPFSTGKRICLGES 440

  Fly   505 LVRGFGFLLLANIIQNYNVNS 525
            :.|...||...:|:||::|.|
Mouse   441 IARNELFLFFTSILQNFSVAS 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	p450	52..549	CDD:299894	135/494 (27%)
Cyp2b10	NP_034129.1	p450	42..488	CDD:278495	129/482 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010