DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spok and Cyp2a12

DIOPT Version :9

Sequence 1:	NP_001104460.2	Gene:	spok / 5740359	FlyBaseID:	FBgn0086917	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_598418.1	Gene:	Cyp2a12 / 13085	MGIID:	105055	Length:	492	Species:	Mus musculus

Alignment Length:	488	Identity:	126/488 - (25%)
Similarity:	213/488 - (43%)	Gaps:	81/488 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 PGPHPWPIIGNINLLGRFQYNPFYGFGTLTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKY 116
            |||.|.|.|||...|.|  .:.:.....|.:.||.::::.||..|.:|:...|.:||.|..:.:.
Mouse    34 PGPIPLPFIGNYLQLNR--KDVYSSITQLQEHYGPVFTIHLGPRRVVVLYGYDAVKEALVDHAEE 96

  Fly   117 FGGRPDFFRYHKLFGGDRNNSLALCDWSQLQQKRR---------NLARRHCSPRESSSYFSKMSE 172
            |.||.:...::.||.|   ..:|..:..:.:|.||         .:.:|....|        :.|
Mouse    97 FSGRGEQATFNTLFKG---YGVAFSNGERAKQLRRFSIATLRDFGMGKRGVEER--------IQE 150

  Fly   173 IGGLEVNQLLDQLTNISSGYPCDVKPLILAASANMFCQYMCSVRFNYSDKGFQKIIEYFDEI--F 235
            ..|..:..|..     :.|.|.|....:...::|:....:...||||.||.|..:::...::  |
Mouse   151 EAGCLIKMLQG-----TCGAPIDPTIYLSKTASNVISSIVFGDRFNYEDKEFLSLLQMMGQVNKF 210

  Fly   236 WEINQGYSFDYIPWLVPFYCNHISRIVHWSASIRKFILERIVNHRESNININEPDKDFTDALLKS 300
            .....|..:|....::.:......:|:..|..:..|:::: |...:|.::.|.| :||.|:.|..
Mouse   211 AASPTGQLYDMFHSVMKYLPGPQQQIIKDSHKLEDFMIQK-VKQNQSTLDPNSP-RDFIDSFLIH 273

  Fly   301 LKEDKNVS-----RNTIIFMLEDFIGGHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIR 360
            ::::|.|:     :|.::..|..|..|...|.:.:......:.|:|.:...:..|:|.|..:. |
Mouse   274 MQKEKYVNSEFHMKNLVMTSLNLFFAGSETVSSTLRYGFLLLMKHPDVEAKVHEEIDRVIGRN-R 337

  Fly   361 RICLYDMNVMPYTMASISEVLRYSS-SPI-VPHVAMEDTVIKGFGVRKGTIVFINNYVLNMSESF 423
            :....|...||||.|.|:|:.|:|: :|: :|....:||..:||.:.|||.||.....|.....|
Mouse   338 QPQYEDHMKMPYTQAVINEIQRFSNFAPLGIPRRITKDTSFRGFFLPKGTEVFPILGSLMTDPKF 402

  Fly   424 WNHPEQFDPERFLENNFTNNKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIP 488
            ::.|:.|:|:.||                          |:.|.               ||| ||
Mouse   403 FSSPKDFNPQHFL--------------------------DDKGQ---------------LKK-IP 425

  Fly   489 QFLPFSVGKRTCIGQSLVRGFGFLLLANIIQNY 521
            .|||||.|||.|:|.||.:...||....|:||:
Mouse   426 AFLPFSTGKRFCLGDSLAKMELFLFFTTILQNF 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	p450	52..549	CDD:299894	126/488 (26%)
Cyp2a12	NP_598418.1	p450	33..489	CDD:278495	126/488 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920