DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spok and Cyp1b1

DIOPT Version :9

Sequence 1:	NP_001104460.2	Gene:	spok / 5740359	FlyBaseID:	FBgn0086917	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_034124.1	Gene:	Cyp1b1 / 13078	MGIID:	88590	Length:	543	Species:	Mus musculus

Alignment Length:	566	Identity:	149/566 - (26%)
Similarity:	246/566 - (43%)	Gaps:	104/566 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LLLKCKQKAFVVIG--LLYQEKKYQCFDQAPGPHPWPIIGNINLLGRFQYNPFYGFGTLTKKYGD 86
            |||.....|.|.:|  ||.|.:: :.:...|||.|||:|||...:|  |.:..| |..|.::|||
Mouse    23 LLLLFSVLAAVHLGQWLLRQWQR-KPWSSPPGPFPWPLIGNAAAVG--QASHLY-FARLARRYGD 83

  Fly    87 IYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGRPDFFRYHKLFGGDRNNSLALCDWSQ--LQQK 149
            ::.:.||....:|:|....|.:.|.:.|..|..||.|..:..:.||   .|||...:|:  ..|:
Mouse    84 VFQIRLGSCPVVVLNGESAIHQALVQQGSIFADRPPFASFRVVSGG---RSLAFGHYSEHWKTQR 145

  Fly   150 R------RNLARRHCSPRESSSYFSKMSEIGGL-------EVNQLLDQLTNISSG--YPCDVKPL 199
            |      |..:.||  ||..           ||       |..:|:..|....:|  :....:|:
Mouse   146 RSAYSTMRAFSTRH--PRSR-----------GLLEGHALAEARELVAVLVRRCAGGAFLDPTQPV 197

  Fly   200 ILAASANMFCQYMCSVRFNYSDKGFQKIIEYFDEIFWEINQGYSFDYIPWLVPFYCNHI----SR 260
            |:|. ||:........|:|:.|..|.:::.:.:|....:..|...|.:||| ..:.|.:    .:
Mouse   198 IVAV-ANVMSAVCFGCRYNHDDAEFLELLSHNEEFGRTVGAGSLVDVLPWL-QLFPNPVRTTFRK 260

  Fly   261 IVHWSASIRKFILERIVNHRESNININEPDKDFTDALLKSLK---------EDKNVSRNTIIFML 316
            ....:.:...|:|::.:.||||.:....| :|.|||.:.|.:         :...:....:...:
Mouse   261 FEQLNRNFSNFVLDKFLRHRESLVPGAAP-RDMTDAFILSAEKKASGAPGDDSSGLDLEDVPATI 324

  Fly   317 EDFIG-GHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIRRICLYDMNVMPYTMASISEV 380
            .|..| ....:...::..|....:.|.:...::.|:|.|..:. |..|:.|...:||.||.:.|.
Mouse   325 TDIFGASQDTLSTALLWLLILFTRYPDVQARVQAELDQVVGRD-RLPCMSDQPNLPYVMAFLYES 388

  Fly   381 LRYSS-SPI-VPHVAMEDTVIKGFGVRKGTIVFINNYVLNMSESFWNHPEQFDPERFLENNFTNN 443
            :|:|| .|: :||....:|.:.|:.:.|.|:||:|.:.:|...:.|.:||.|||.|||
Mouse   389 MRFSSFLPVTIPHATTANTFVLGYYIPKNTVVFVNQWSVNHDPAKWPNPEDFDPARFL------- 446

  Fly   444 KESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQFLPFSVGKRTCIGQSLVRG 508
                               |.||           ..||.|..|:   :.||||||.|||:.|.:.
Mouse   447 -------------------DKDG-----------FINKALASSV---MIFSVGKRRCIGEELSKM 478

  Fly   509 FGFLLLANIIQ--NYNVNSADFSKIKLEKSSIALPKKCFKL--SLR 550
            ..||.::.:..  |:..|..:.|.:.. ...:.:..|.|::  |||
Mouse   479 LLFLFISILAHQCNFKANQNESSNMSF-SYGLTIKPKSFRIHVSLR 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	p450	52..549	CDD:299894	137/533 (26%)
Cyp1b1	NP_034124.1	p450	51..518	CDD:365848	137/530 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920