DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spok and Cyp2c50

DIOPT Version :9

Sequence 1:	NP_001104460.2	Gene:	spok / 5740359	FlyBaseID:	FBgn0086917	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_598905.2	Gene:	Cyp2c50 / 107141	MGIID:	2147497	Length:	490	Species:	Mus musculus

Alignment Length:	545	Identity:	150/545 - (27%)
Similarity:	230/545 - (42%)	Gaps:	123/545 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IAITIILISYVFLLLKCKQKAFVVIGLLYQEKKYQCFDQAPGPHPWPIIGNINLLGRFQYNP--- 73
            |.:.:..:|.:|||...:|.:        :..|.     .|||.|.||||||     .|.|.
Mouse     4 ILVLVFTLSCLFLLSLWRQSS--------ERGKL-----PPGPTPLPIIGNI-----LQINVKDI 50

  Fly    74 FYGFGTLTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGRPDFFRYHKLFGG-----D 133
            ...|..|:|.||.:|:|.||....:|::..:.:||.|..:|:.|.||.....:.|...|     .
Mouse    51 CQSFTNLSKVYGPVYTLYLGRKPTVVLHGYEAVKEALVDHGEEFAGRGRLPVFDKATNGMGIIFS 115

  Fly   134 RNNSLALCDWSQLQQ----KRRNL--ARRHCSPRESSSYFSKMSEIGGLEVNQLLDQLTNISSGY 192
            :.|.     |...::    ..|||  .:|....|...            |...|:::|.. ::|.
Mouse   116 KGNV-----WKNTRRFSLTTLRNLGMGKRSIEDRVQE------------EARCLVEELRK-TNGS 162

  Fly   193 PCDVKPLILAASANMFCQYMCSVRFNYSDKGFQKIIEYFDEIFWEINQGYSFDYIPWL-----VP 252
            |||...::..|..|:.|..:...||:|.|:.|..::|..:||...::       .|||     .|
Mouse   163 PCDPTFILGCAPCNVICSIIFQDRFDYKDRDFLNLMEKLNEITKIMS-------TPWLQVCNTFP 220

  Fly   253 F---YC--NHISRIVHWSASIRKFILERIVNHRESNININEPDKDFTDALLKSLKED------KN 306
            .   ||  :| :::....|.|:.|:||:|..|.|| :::..| :||.|..|.:..::      ||
Mouse   221 VLLDYCPGSH-NKVFKNYACIKNFLLEKIKEHEES-LDVTIP-RDFIDYFLINGGQENGNYPLKN 282

  Fly   307 VSRNTIIFMLEDFIGGHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIRRICLYDMNVMP 371
            ...:..|.:.:.|..|.......:..||..:.|.|.:...::.|::.|..|. ||.|:.|.:.||
Mouse   283 RLEHLAITVTDLFSAGTETTSTTLRYALLLLLKYPHVTAKVQEEIEHVIGKH-RRPCMQDRSHMP 346

  Fly   372 YTMASISEVLRYSS--SPIVPHVAMEDTVIKGFGVRKGTIVFIN-NYVLNMSESFWNHPEQFDPE 433
            ||.|.|.||.|:..  ...:||....|...:.:.:.|||.|..: :.||..|:.|.| ||:|||.
Mouse   347 YTDAMIHEVQRFIDLVPNSLPHEVTCDIKFRNYFIPKGTNVITSLSSVLRDSKEFPN-PEKFDPG 410

  Fly   434 RFLENNFTNNKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQFLPFSVGKR 498
            .||:.|                          |..|...|                |:|||.|||
Mouse   411 HFLDEN--------------------------GKFKKSDY----------------FMPFSTGKR 433

  Fly   499 TCIGQSLVRGFGFLLLANIIQNYNV 523
            .|.|:.|.|...||.|.:|:||:|:
Mouse   434 ICAGEGLARMELFLFLTSILQNFNL 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	p450	52..549	CDD:299894	143/505 (28%)
Cyp2c50	NP_598905.2	p450	30..487	CDD:278495	143/506 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920