Protein Alignment spok and Cyp2c50

DIOPT Version :10

• Sequence 1: NP_001104460.2
• Gene: spok / 5740359
• FlyBaseID: FBgn0086917
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_598905.2
• Gene: Cyp2c50 / 107141
• MGIID: 2147497
• Length: 490
• Species: Mus musculus
• Alignment Length: 545
• Identity: 150/545 - (27%)
• Similarity: 230/545 - (42%)
• Gaps: 123/545 - (22%)

  Fly    12 IAITIILISYVFLLLKCKQKAFVVIGLLYQEKKYQCFDQAPGPHPWPIIGNINLLGRFQYNP--- 73
            |.:.:..:|.:|||...:|.:        :..|.     .|||.|.||||||     .|.|.
Mouse     4 ILVLVFTLSCLFLLSLWRQSS--------ERGKL-----PPGPTPLPIIGNI-----LQINVKDI 50

  Fly    74 FYGFGTLTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGRPDFFRYHKLFGG-----D 133
            ...|..|:|.||.:|:|.||....:|::..:.:||.|..:|:.|.||.....:.|...|     .
Mouse    51 CQSFTNLSKVYGPVYTLYLGRKPTVVLHGYEAVKEALVDHGEEFAGRGRLPVFDKATNGMGIIFS 115

  Fly   134 RNNSLALCDWSQLQQ----KRRNL--ARRHCSPRESSSYFSKMSEIGGLEVNQLLDQLTNISSGY 192
            :.|.     |...::    ..|||  .:|....|...            |...|:::|.. ::|.
Mouse   116 KGNV-----WKNTRRFSLTTLRNLGMGKRSIEDRVQE------------EARCLVEELRK-TNGS 162

  Fly   193 PCDVKPLILAASANMFCQYMCSVRFNYSDKGFQKIIEYFDEIFWEINQGYSFDYIPWL-----VP 252
            |||...::..|..|:.|..:...||:|.|:.|..::|..:||...::       .|||     .|
Mouse   163 PCDPTFILGCAPCNVICSIIFQDRFDYKDRDFLNLMEKLNEITKIMS-------TPWLQVCNTFP 220

  Fly   253 F---YC--NHISRIVHWSASIRKFILERIVNHRESNININEPDKDFTDALLKSLKED------KN 306
            .   ||  :| :::....|.|:.|:||:|..|.|| :::..| :||.|..|.:..::      ||
Mouse   221 VLLDYCPGSH-NKVFKNYACIKNFLLEKIKEHEES-LDVTIP-RDFIDYFLINGGQENGNYPLKN 282

  Fly   307 VSRNTIIFMLEDFIGGHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIRRICLYDMNVMP 371
            ...:..|.:.:.|..|.......:..||..:.|.|.:...::.|::.|..|. ||.|:.|.:.||
Mouse   283 RLEHLAITVTDLFSAGTETTSTTLRYALLLLLKYPHVTAKVQEEIEHVIGKH-RRPCMQDRSHMP 346

  Fly   372 YTMASISEVLRYSS--SPIVPHVAMEDTVIKGFGVRKGTIVFIN-NYVLNMSESFWNHPEQFDPE 433
            ||.|.|.||.|:..  ...:||....|...:.:.:.|||.|..: :.||..|:.|.| ||:|||.
Mouse   347 YTDAMIHEVQRFIDLVPNSLPHEVTCDIKFRNYFIPKGTNVITSLSSVLRDSKEFPN-PEKFDPG 410

  Fly   434 RFLENNFTNNKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQFLPFSVGKR 498
            .||:.|                          |..|...|                |:|||.|||
Mouse   411 HFLDEN--------------------------GKFKKSDY----------------FMPFSTGKR 433

  Fly   499 TCIGQSLVRGFGFLLLANIIQNYNV 523
            .|.|:.|.|...||.|.:|:||:|:
Mouse   434 ICAGEGLARMELFLFLTSILQNFNL 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	CYP1_2-like	85..547	CDD:410710	127/469 (27%)
Cyp2c50	NP_598905.2	CYP2C-like	61..485	CDD:410758	128/470 (27%)