Protein Alignment spok and cyp2a6

DIOPT Version :10

• Sequence 1: NP_001104460.2
• Gene: spok / 5740359
• FlyBaseID: FBgn0086917
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_001120541.1
• Gene: cyp2a6 / 100145695
• XenbaseID: XB-GENE-5903934
• Length: 495
• Species: Xenopus tropicalis
• Alignment Length: 563
• Identity: 144/563 - (25%)
• Similarity: 225/563 - (39%)
• Gaps: 126/563 - (22%)

  Fly    24 LLLKCKQKAFVVIGLLYQEK---KYQCFDQAPGPHPWPIIGNINLLGRFQYNPFYGFGTLTKKYG 85
            ||..|      ||.|||..|   |.:..:..|||..:|::||...:|..:...  .|..|:|.||
 Frog    10 LLSVC------VIILLYLVKWRGKSKSKNLPPGPTAYPLLGNFPQIGLREIPS--SFVQLSKTYG 66

  Fly    86 DIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGRPDFFRYHKLF--------GGDRNNSLALCD 142
            .:|:|.||..|.||:...|.:||.|......|..|........||        .|:|
 Frog    67 PVYTLYLGGHRLIVLIGHDAVKEALIDQSDVFSDRGRLGISQVLFDEHGVIMSNGER-------- 123

  Fly   143 WSQLQQ----KRRNLARRHCSPRESSSYFSKMSEIGGLEVNQLLDQLTNISSGYPCDVKPLILAA 203
            |..:::    ..||......|..|...           |..:.|::........|.|...|:..|
 Frog   124 WKTMRRFTLTTLRNFGMGKRSVEERIQ-----------EEARSLEEAFRKKKDEPFDPVNLLGPA 177

  Fly   204 SANMFCQYMCSVRFNYSDKGFQKIIEYFDEIFWEINQGYSFDYIPWLVPFYCNHI----SRIVHW 264
            .:|:.|..:...||:|.|:.|..:::...|:...:|.  .|..:..:.|....||    ..|..:
 Frog   178 VSNIICSIIFGDRFDYEDEKFTTLLKCMRELINLLNS--LFGQLVNVFPNLSQHIPGPHQNIFTY 240

  Fly   265 SASIRKFILERIVNHRESNININEPDKDFTDALLKSLKEDKNVSRNT---------IIFMLEDFI 320
            ...|::|:.:...:|::: ::.|.| :||.|..|..::|:| ::.||         :||.|  |.
 Frog   241 FNKIKQFVKDEAKSHKDT-LDANCP-RDFIDCFLIRMEEEK-MNPNTEFHNDNLFAVIFDL--FF 300

  Fly   321 GGHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIRRICLYDMNVMPYTMASISEVLRYSS 385
            .|.......:..|.....|.|.:...:..|:|.|..:. |.....|...||||.|.|.||.|::.
 Frog   301 AGTETSSLTLRYAFLIFLKYPEVQEKVYKEIDQVIGQN-RYPSFEDKIKMPYTEAVIHEVQRFAD 364

  Fly   386 SPIVP----HVAMEDTVIKGFGVRKGTIVF-INNYVLNMSESFWNHPEQFDPERFLENNFTNNKE 445
              |||    |...:||..:|:.:.|||.|| :...||. ...::.:|:||||..||:.|
 Frog   365 --IVPTGLEHKTSKDTTFRGYDIPKGTSVFPVLTSVLK-DPKYFKNPDQFDPGHFLDEN------ 420

  Fly   446 SGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNKLLKKSIPQFLPFSVGKRTCIGQSLVRGFG 510
               .|        .:|||                         .|:|||.|||.|.|:.|.|...
 Frog   421 ---GC--------FKKND-------------------------AFMPFSAGKRMCAGEGLARMEL 449

  Fly   511 FLLLANIIQNYNVNSADFSKIKLEKSSIALPKKCFKLSLRPRT 553
            |:.|.:|:|.:.:..             .:|.:..|::.:|:|
 Frog   450 FIFLTSILQKFTLKP-------------TVPAETIKITPQPKT 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spok	NP_001104460.2	CYP1_2-like	85..547	CDD:410710	120/491 (24%)
cyp2a6	NP_001120541.1	cytochrome_P450	65..489	CDD:477761	124/500 (25%)