DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34357 and Gyc76C

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster

Alignment Length:	1354	Identity:	411/1354 - (30%)
Similarity:	581/1354 - (42%)	Gaps:	338/1354 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   448 ILLIDMAASSLDTQHGFYKYLSRMGGSQSDAFARNTGSPAEVVSSNLLVLTLLNDRHRLFLNAAG 512
            ::.:||...|   :....|||.|:   ....|..|..|...           .|...|..|..|.
  Fly   256 VIFVDMMVYS---EREAEKYLRRV---DQITFMSNCHSTEN-----------FNQMARSLLVVAS 303

  Fly   513 LMATMQ--NFRAPLNGNYKDPPPSGHRNASLHKLYPYRNLLP--------LYDTIVTTTTQSD-- 565
            ...|..  .|...:. .|...||.   |..:.:|:...|...        |||::.......|
  Fly   304 TPPTKDYIQFTKQVQ-KYSSKPPF---NLEIPRLFVESNFSKFISIYAAYLYDSVKLYAWAVDKM 364

  Fly   566 -TSETSPQFDFVVLDI------VRDAPVATYKWRPL----LILESDPGSRGGGSVVEGGGSYISH 619
             ..||....|.|:.::      |.|..:....:..:    :.::....|.|..||:    :|..|
  Fly   365 LREETRVLTDDVIFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQYGDSEGNFSVL----AYKPH 425

  Fly   620 S------------------IHPG--YDEWLLVSSVLLWQCGA-------ICWTIAAIC------- 650
            .                  .|.|  :.|:.|::..:.|..|.       :|.....:|
  Fly   426 KWNNSNNMPCNYHMVPVAYFHQGEEHPEYKLINGSIDWPSGGEKPADEPMCGFANELCKKDDTHY 490

  Fly   651 ---VCLLVIMIAGIVAGGIAMRNYFLRKRLSKGPNKIVLSASDFVFPVDSRRVDEGIEAMLCCWL 712
               |..:|:.:....:|.|.|..|  ||                      .:::..||.:|  |
  Fly   491 TSTVAAVVLGVLLFCSGVITMSIY--RK----------------------WKIELEIEGLL--W- 528

  Fly   713 QQLQEFGGPEVDKPDLLKGSIGSLKNLGFVIPGAAAPGSAGAITTTANGKSGSSATGSLARHNPA 777
                     ::| |:.:||..|:                  .|.::.:..|..||....:|....
  Fly   529 ---------KID-PNEIKGYSGN------------------EIVSSPSKVSLMSAQSYGSRWTNQ 565

  Fly   778 HLDMRARYNGDLVQLKEVNINGSAELRTKAMDLLVMAHGLRHENINPLIGWLSDPNRTAMVFDYC 842
            .:....|..|.:|::||:......::..:.|..:.:...|||:|||..||...:|.|..:|.|||
  Fly   566 FVTSTGRLRGAVVRIKELKFPRKRDISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYC 630

  Fly   843 SRGSLQDVLIMDEIKLDWSFRLSLLTDLVRGMRYLHTSPLRVHGALTSRNCVVDARWVLKITDYG 907
            ::|||.|::..::||||..|..||:.||::||.|:|.|.|..||.|.|.||||.:||:|::||:|
  Fly   631 AKGSLYDIIENEDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFG 695

  Fly   908 LNSF-----YESQGLPPRTRSAKELLWTAPELLRNMKLHQHHHQHGRIQLGTQLGDVYSFGIIMQ 967
            |:..     .||.|.....|:.   ||.|||||||       |.|     |:|.||||:|.|||.
  Fly   696 LHELRQCAENESIGEHQHYRNQ---LWRAPELLRN-------HIH-----GSQKGDVYAFAIIMY 745

  Fly   968 EVVVRGEPYCMLSLSPEEIIVKIKKPP--------PLIRPSVSKGAAPPEAINIMRQCWAEQPDM 1024
            |:..|..|:..::..|:||:..:||.|        |.:...:...:.|...:..:|.||||.|:.
  Fly   746 EIFSRKGPFGQINFEPKEIVDYVKKLPLKGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEE 810

  Fly  1025 RPDFNSVYERFKMLNHGRKVNFVDTMFQMLEKYSNNLEELIRERTEQLDIERKKTEQLLNRMLPS 1089
            ||:|:.:..|.|.:..|:..|.:|.|.:|:|||:||||:::.|||..|..|:.|||.||:||||.
  Fly   811 RPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQ 875

  Fly  1090 SVAEKLKMGLAVDPEEFSDVTIYFSDIVGFTTIAAHCSPVQVVDLLNDLYTIFDATINAYNVYKV 1154
            ||||||.||..|:|..:..||||||||||||.::|..:|:|||:.||||||:||..|..|:||||
  Fly   876 SVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKV 940

  Fly  1155 ETIGDAYMVVSGLPVKIPD-HAEQIATMALDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVV 1218
            ||||||||||||||:|..| ||.:||:|||:|||...:..:.|.|...|:||||:||||..||||
  Fly   941 ETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVV 1005

  Fly  1219 GLTMPRYCLFGDTVNTASRMESTGSSWRIHMSQETRDRLD-ARGGYAIEPRGLIDIKGKGMMNTF 1282
            ||||||||||||||||||||||.|.:.:||:|.:.:..|| ..|||..|.|||:::||||.:.|:
  Fly  1006 GLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTW 1070

  Fly  1283 WLLGKKG-----------------FDKPLPAP--------PPIGESHGLDESLIRNSITLKAQAN 1322
            ||.|...                 |.:|..:|        |.|...|.......|.|...:|...
  Fly  1071 WLTGANENAIQKKLVDMMDMPPPLFSRPRKSPKLNPDSRQPSIQAMHFCGTGSRRQSTVPRAMDG 1135

  Fly  1323 KSRTSTNPSSSQSSSL-----------------AG--------ESVEVKVEI-----TPPTNADL 1357
            :|..|...|..:|..:                 ||        ||.:..:..     |..||.|:
  Fly  1136 ESTYSLQGSVRESPRMVSKRDRDRERPPINGLGAGHFVGGALLESAQASLSTLNHSETNETNCDM 1200

  Fly  1358 ASGTNLPNSYSLDSNSTNTISPNA---TLCPEFPGKTTPSSTSPQ---------------SRKLS 1404
            ..|:...:.    |.|.....|||   .|....|.:...::..||               ||.|.
  Fly  1201 DGGSGGVSG----SGSGLVRQPNALHKPLAMVRPHRIISAAQLPQLGDNDDDSADTLLRESRSLD 1261

  Fly  1405 ELTPENLLNPNSFNRLPSS-----------TGGS-----------SSRL---YKKIEEMMDLSSP 1444
            .:..:.|...:...:||.|           ||.|           ||:|   .:.....:|.:..
  Fly  1262 PMPMQQLRKRHDRVKLPPSKLSKNNSRSLDTGVSLISGNPNGEVHSSQLDLDNEMTANPVDATDG 1326

  Fly  1445 YNHYKCLSPSESNLTQFYDGKYL------------------YGSVAGGAGGGQAGGGA-CASIAL 1490
            |:       .|..|...:|...|                  .|..|||.|||:.|||: ||...
  Fly  1327 YD-------DELGLLMRHDNGQLPALRYSGSFPNAQISIVPTGRSAGGGGGGREGGGSNCAKHL- 1383

  Fly  1491 SGSGCGGGASRFDSKPGSSRLLRRQFSLDRDDQQAKGEQQHHQHSLQANTYSGLVGGCGGGVKSS 1555
             .:.|.||.:..|..  .|.||:||.||....::.....: ..|||:.      :.|.||
  Fly  1384 -NNNCNGGVNVEDDL--ESPLLQRQASLSVPPEEMLAHNK-RWHSLEH------MDGPGG----- 1433

  Fly  1556 MLDIPLLHDTTRSPKGTLTRSHKQNSASITQDLEKIEEIPL---SPASSQHHSS 1606
                                 |..||.|...|::......|   |.:|:|||.|
  Fly  1434 ---------------------HGGNSVSYAADIDNRHPGDLDFFSGSSNQHHRS 1466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	105/290 (36%)
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	123/193 (64%)
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	38/213 (18%)
		ANF_receptor	48..412	CDD:279440	32/176 (18%)
		PK_GC-A_B	543..827	CDD:270944	106/298 (36%)
		HNOBA	<835..881	CDD:285003	27/45 (60%)
		CYCc	860..1052	CDD:214485	122/191 (64%)
		Guanylate_cyc	887..1074	CDD:278633	116/186 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9715
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.910