DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34357 and Gucy2d

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	NP_077356.1	Gene:	Gucy2d / 79222	RGDID:	620438	Length:	1108	Species:	Rattus norvegicus

Alignment Length:	1092	Identity:	396/1092 - (36%)
Similarity:	541/1092 - (49%)	Gaps:	245/1092 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   314 AEQLALDFNKTVVLWPCPRMKISSNFLPSFEAISLAVQSISTKLNWSQVDIYIG-DDNW------ 371
            ||.||.:....:|.|.||..:.:....|:....:.|:..:.....|::|.:... .|.|
  Rat   139 AELLAQEAGVALVPWGCPGTRAAGTTAPAVTPAADALYVLLKAFRWARVALITAPQDLWVEAGRA 203

  Fly   372 --------GLGLAIAANLHVPYRI----EIGRTIRDLHSQDKPGKAIIITAPLNDASTILLLSTI 424
                    ||.:|:..:: ||..:    |..|.|||       |..:.:        .|:::.::
  Rat   204 LSTALRARGLPVALVTSM-VPSDLSGAREALRRIRD-------GPRVRV--------VIMVMHSV 252

  Fly   425 ELDWTEQARKDGQGSRPGRQHTKILLIDMAASSLDTQHGFYKYLSRMGGSQSDAFARNTGSPAEV 489
            .|...||..........|.....::.:     ..||.|    |....|.....||         |
  Rat   253 LLGGEEQRYLLEAAEELGLTDGSLVFL-----PFDTLH----YALSPGPEALAAF---------V 299

  Fly   490 VSSNL-----LVLTLLNDRHRLFLNAAGLMATMQNFRAPLNGNYKDPPPSGHRNASLHKLYP--- 546
            .||.|     .||||..                   |.|..|:.:|    ..|.|..|:..|
  Rat   300 NSSKLRRAHDAVLTLTR-------------------RCPPGGSVQD----SLRRAQEHQELPLDL 341

  Fly   547 -YRNLLPLYDTI----------VTTTTQS----------------------------DTSETSPQ 572
             .:.:.||:.||          ||....:                            .|.|.|
  Rat   342 DLKQVSPLFGTIYDAVFLLAGGVTRARAAVGGGWVSGASVARQMREAQVFGFCGILGRTEEPS-- 404

  Fly   573 FDFVVLDIVRDAP----VATYKWRPLLILESDPGS-RGGGSVVEGGGSYISHSIHPGYDEWLLVS 632
              ||:||  .||.    ..|:...|:|      || |..|:.|.    :...:..||.|
  Rat   405 --FVLLD--TDAAGERLFTTHLLDPVL------GSLRSAGTPVH----FPRGAPAPGPD------ 449

  Fly   633 SVLLWQCGAICW-TIAAIC----------VCLLVIMIAGIVAGGIA--MRNYFLRKRLSKGPNKI 684
                    ..|| ....||          |..|::::.|:....:|  :|:..|..::..|||||
  Rat   450 --------PSCWFDPDVICNGGVEPGLVFVGFLLVIVVGLTGAFLAHYLRHRLLHMQMVSGPNKI 506

  Fly   685 VLSASDFVFPVDSRRVDEGIEAMLCCWLQQLQEFGGPEVDKPDLLKGSIGSLKNLGFVIPGAAAP 749
            :|:..|..|                     |...||   ....:.:||..||
  Rat   507 ILTLEDVTF---------------------LHPQGG---SSRKVAQGSRSSL------------- 534

  Fly   750 GSAGAITTTANGKSGSSATGSLARHNPAHLDMRARYNGDLVQLKEVNINGSAELRTKAMDLLVMA 814
                |..:|::.:|..|        .|........|.||.|.||:........:|..........
  Rat   535 ----ATRSTSDIRSVPS--------QPQESTNIGLYEGDWVWLKKFPGEHHMAIRPATKMAFSKL 587

  Fly   815 HGLRHENINPLIGWL----SDPNRT------AMVFDYCSRGSLQDVLIMDEIKLDWSFRLSLLTD 869
            ..|||||:...:|..    :|...|      |:|.::|:||||.|:|...:|||||.|:.|||.|
  Rat   588 RELRHENVALYLGLFLAGTADSPATPGEGILAVVSEHCARGSLHDLLAQRDIKLDWMFKSSLLLD 652

  Fly   870 LVRGMRYLHTSPLRVHGALTSRNCVVDARWVLKITDYGLNSFYESQGLPPRTRSAKELLWTAPEL 934
            |::||||||...: .||.|.|||||||.|:|||:||:|.....|:|.:.|...||::.|||||||
  Rat   653 LIKGMRYLHHRGV-AHGRLKSRNCVVDGRFVLKVTDHGHGRLLEAQRVLPEPPSAEDQLWTAPEL 716

  Fly   935 LRNMKLHQHHHQHGRIQLGTQLGDVYSFGIIMQEVVVRGEPYCMLSLSPEEIIVKIKKPPPLIRP 999
            ||:..|.:.         ||..|||:|.||||||||.|..||.||.|:|||:|.:::.||||.||
  Rat   717 LRDPALERR---------GTLAGDVFSLGIIMQEVVCRSTPYAMLELTPEEVIQRVRSPPPLCRP 772

  Fly  1000 SVSKGAAPPEAINIMRQCWAEQPDMRPDFNSVYERFKMLNHGRKVNFVDTMFQMLEKYSNNLEEL 1064
            .||...||.|.|.:|.|||||.|::||..:..::.||.:|.|||.|.:|:|.:|||:||:|||:|
  Rat   773 LVSMDQAPMECIQLMAQCWAEHPELRPSMDLTFDLFKGINKGRKTNIIDSMLRMLEQYSSNLEDL 837

  Fly  1065 IRERTEQLDIERKKTEQLLNRMLPSSVAEKLKMGLAVDPEEFSDVTIYFSDIVGFTTIAAHCSPV 1129
            ||||||:|:.|::||::||.:|||.||||.||||.:|:||.|.:||:|||||||||||:|...|:
  Rat   838 IRERTEELEQEKQKTDRLLTQMLPPSVAEALKMGTSVEPEYFEEVTLYFSDIVGFTTISAMSEPI 902

  Fly  1130 QVVDLLNDLYTIFDATINAYNVYKVETIGDAYMVVSGLPVKIPD-HAEQIATMALDLLHQSGRFN 1193
            :||||||||||:|||.|.:::|||||||||||||.||||.:... ||.:||.|:||:|...|.|.
  Rat   903 EVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGSFR 967

  Fly  1194 VKHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGSSWRIHMSQETRDRLD 1258
            ::|:|.||:::|||||:|||.||||||||||||||||||||||||||||..:|||::..|...|.
  Rat   968 MRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNMSTVRILR 1032

  Fly  1259 ARG-GYAIEPRGLIDIKGKGMMNTFWLLGKKGFDKPLPAPP---PIGESHGL 1306
            |.. |:.:|.||..::||||:.:|:||:|:.||:||:|.||   |...:||:
  Rat  1033 ALDQGFQMECRGRTELKGKGVEDTYWLVGRVGFNKPIPKPPDLQPGASNHGI 1084

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	124/287 (43%)
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	123/193 (64%)
Gucy2d	NP_077356.1	PBP1_sensory_GC_DEF-like	58..434	CDD:380594	74/363 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	520..552		11/59 (19%)
		PK_GC-2D	540..814	CDD:270945	124/291 (43%)
		HNOBA	<823..868	CDD:400168	29/44 (66%)
		CYCc	848..1039	CDD:214485	123/190 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1069..1108		6/16 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	239	1.000	Domainoid score	I2206
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	1	1.000	-	-		FOG0002312
OrthoInspector	1	1.000	-	-		otm46397
orthoMCL	1	0.900	-	-		OOG6_103194
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1738
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.780