DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34357 and Gucy1a2

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	NP_076446.1	Gene:	Gucy1a2 / 66012	RGDID:	621655	Length:	730	Species:	Rattus norvegicus

Alignment Length:	247	Identity:	105/247 - (42%)
Similarity:	141/247 - (57%)	Gaps:	6/247 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly  1054 LEKYSNNLEELIRERTEQLDIERKKTEQLLNRMLPSSVAEKLKMGLAVDPEEFSDVTIYFSDIVG 1118
            |:|..:.|:..:.:..:.|:.|:|||..||..:.|..||::|.....|...:|.|||:.||||||
  Rat   463 LKKRMDKLKATLEKTHQALEEEKKKTVDLLYSIFPGDVAQQLWQRQQVQARKFDDVTMLFSDIVG 527

  Fly  1119 FTTIAAHCSPVQVVDLLNDLYTIFDATINAYNVYKVETIGDAYMVVSGLPVKIPDHAEQIATMAL 1183
            ||.|.|.|:|:||:.:||:|||.||......::||||||||||.|.|||..|...||:.||.|||
  Rat   528 FTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVASGLHRKSLCHAKPIALMAL 592

  Fly  1184 DLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGSSWRIH 1248
            .::..|.  .|....|.|:|:|||:|:|...|||||:.||||||||:.|..||:.||.....||:
  Rat   593 KMMELSE--EVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRIN 655

  Fly  1249 MSQETRDRLDARGGYAIEPRG---LIDIKGKGMMNTFWLLGKKGFDKPLPAP 1297
            :|..|...|.....:...||.   |.|...|.:....:.|..:...|| |.|
  Rat   656 ISPTTYQLLKREDSFTFIPRSREELPDNFPKEIPGVCYFLELRTGPKP-PKP 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	91/191 (48%)
Gucy1a2	NP_076446.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53
		HNOB	<157..268	CDD:285002
		HNOBA	314..501	CDD:285003	11/37 (30%)
		CYCc	483..672	CDD:214485	91/190 (48%)
		Guanylate_cyc	512..696	CDD:278633	85/185 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810