DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34357 and Adcy5

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	NP_072122.2	Gene:	Adcy5 / 64532	RGDID:	71014	Length:	1262	Species:	Rattus norvegicus

Alignment Length:	794	Identity:	170/794 - (21%)
Similarity:	279/794 - (35%)	Gaps:	258/794 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   716 QEFGGPEVDKPDLLKGSIGSLKNLGFVIPGAAAPGSAGAITTTANGKSGSSATGSLARHNPAHLD 780
            ||.||.:        |..||.:..    .|||..||..|   ...|.|||||..:.|.
  Rat   105 QERGGDD--------GGRGSRRQR----RGAAGGGSTRA---PPAGGSGSSAAAAAAA------- 147

  Fly   781 MRARYNGDLVQLKEVNINGSAELRTKAMDLLVMAHGLRHENINPLIGWLSDPN------------ 833
                 .|..|:.:.|.: |..|.|.|         |...|.:.|..|.:.|.:
  Rat   148 -----GGTEVRPRSVEV-GLEERRGK---------GRAAEELEPGTGTVEDGDGSEDGGSSVASG 197

  Fly   834 ---RTAMVFDYCSRGSLQ---------DVLIMDEIKLDWSFRL--SLLTDLVR-------GMRYL 877
               .|.:....|....||         |.|  :.:...:.|||  |.||.|:.       .|...
  Rat   198 SGTGTVLSLGACCLALLQIFRSKKFPSDKL--ERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAF 260

  Fly   878 HTS--PLRV----------------------------HGALTSRNCVVDARWVLKITDYGLNSFY 912
            |.:  ||:|                            |..|.   |......||.:...||
  Rat   261 HAARPPLQVVYLAVLAAAVGVILIMAVLCNRAAFHQDHMGLA---CYALIAVVLAVQVVGL---- 318

  Fly   913 ESQGLPPRTRSAKELLWTAPELLRNMKLHQHHHQHGRIQLGTQLGDVYS-FGIIMQEVVVRGEPY 976
                |.|:.|||.|.:|.....:..                     :|: ..:.|:..|:.|...
  Rat   319 ----LLPQPRSASEGIWWTVFFIYT---------------------IYTLLPVRMRAAVLSGVLL 358

  Fly   977 CMLSL-------SPEEIIVKIKKPPPLIRPSVSKGAAPPEAINIMRQC--WAEQPDMRPDFNSVY 1032
            ..|.|       :.::.::|......||.          ...||:..|  :..:...|..|....
  Rat   359 SALHLAISLHTNAQDQFLLKQLVSNVLIF----------SCTNIVGVCTHYPAEVSQRQAFQETR 413

  Fly  1033 ERFKMLNHGRKVNFVDTMFQMLEKYSNNLEELIRERTEQLDIERKKTEQLLNRMLPSSVAEKLKM 1097
            |..:...|.::                               |.::.|:||..:||..||.::|.
  Rat   414 ECIQARLHSQR-------------------------------ENQQQERLLLSVLPRHVAMEMKA 447

  Fly  1098 GLAVDPEEF----------SDVTIYFSDIVGFTTIAAHCSPVQVVDLLNDLYTIFDATINAYNVY 1152
            .:....|:.          .:|:|.|:||.|||::|:.|:..::|..||:|:..||......:..
  Rat   448 DINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCL 512

  Fly  1153 KVETIGDAYMVVSGLPVKIPDHAEQIATMALDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGV 1217
            :::.:||.|..|||||....|||.....|.:|::.....  |:.:.||.:.:|:|:|:|....||
  Rat   513 RIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISL--VREVTGVNVNMRVGIHSGRVHCGV 575

  Fly  1218 VGLTMPRYCLFGDTVNTASRMESTGSSWRIHMSQETRDRLDARGGYAIEPRGLIDIKGKGMMNTF 1282
            :||...::.::.:.|..|:.||:.|.:.|||:::.|.:.|:  |.|.:||       |.|.....
  Rat   576 LGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLN--GDYEVEP-------GCGGERNA 631

  Fly  1283 WLLGKKGFDKPLPAPPPIGESHGLDESLI-------RNSITLKAQANKSRTST---NPSSSQS-- 1335
            :|                 :.|.::..||       :....:.|:.|:.||::   ||....:
  Rat   632 YL-----------------KEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAER 679

  Fly  1336 ---SSLAGESVEVKVEITPPTNADLASGTNLPNSYSLDSNSTNTISPNATLCPEFPGKTTPSSTS 1397
               :.|.|..|..:::         ..|...|.    |.|:..:.:|...: .||.|:..
  Rat   680 PFYNHLGGNQVSKEMK---------RMGFEDPK----DKNAQESANPEDEV-DEFLGRAI----- 725

  Fly  1398 PQSRKLSELTPENL 1411
             .:|.:..|..|::
  Rat   726 -DARSIDRLRSEHV 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	65/350 (19%)
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	62/201 (31%)
Adcy5	NP_072122.2	AC_N	1..459	CDD:318454	90/465 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..196		32/127 (25%)
		Guanylate_cyc	461..634	CDD:306677	57/200 (29%)
		DUF1053	669..761	CDD:399378	16/90 (18%)
		Guanylate_cyc	1063..1257	CDD:306677
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900