DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34357 and Adcy3

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	NP_570135.2	Gene:	Adcy3 / 64508	RGDID:	71009	Length:	1144	Species:	Rattus norvegicus

Alignment Length:	555	Identity:	137/555 - (24%)
Similarity:	225/555 - (40%)	Gaps:	137/555 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   915 QGLPPRTRSAK---ELLW---TAPELLRNMKLHQHHHQHGRIQLGTQLGDVYSFGIIMQEVVVRG 973
            :||.|...|.|   .|||   || ::...:.|:..........:|.|...|:||.|.:.
  Rat   127 KGLLPDRVSRKVVPYLLWLLITA-QIFSYLGLNFSRAHAASDTVGWQAFFVFSFFITLP------ 184

  Fly   974 EPYCMLSLSPEEIIVKIKKPPPLIRPSVSKGAAPP---EAINIMRQCWAEQPDMRPDFNSVY--- 1032
                 |||||..||..:......:...|:......   |.:.::|:..|          :|:
  Rat   185 -----LSLSPIVIISVVSCVVHTLVLGVTVAQQQQDELEGMQLLREILA----------NVFLYL 234

  Fly  1033 -------ERFKMLNHGRKVNFVDTMFQMLEKYSNNLEELIRERTEQLDIERKKTEQLLNRMLPSS 1090
                   ..:.|.:...:..|::.. |.|| ...||||           :.::.|.|:..:||..
  Rat   235 CAIIVGIMSYYMADRKHRKAFLEAR-QSLE-VKMNLEE-----------QSQQQENLMLSILPKH 286

  Fly  1091 VAEKL-----KMGLAVDPEEFS--------DVTIYFSDIVGFTTIAAHCSPVQVVDLLNDLYTIF 1142
            ||:::     |.....|.::|:        :|:|.|:||||||.:::.||..::|.|||:|:..|
  Rat   287 VADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARF 351

  Fly  1143 DATINAYNVYKVETIGDAYMVVSGLPVKIPDHAEQIATMALDLLHQSGRFNVKHLPGVPLQLRIG 1207
            |.....|:..:::.:||.|..:.|||....|||.....|.|.::........|...||  .:|:|
  Rat   352 DKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGV--DMRVG 414

  Fly  1208 LHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGSSWRIHMSQETRDRLDARGGYAIEPR---- 1268
            :|||....||:|....:|.::...|..|::||:.|...|:|:||.|.|.|  :|.:.:||.
  Rat   415 VHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCL--KGEFDVEPGDGGS 477

  Fly  1269 --GLIDIKGKGMMNTFWLLGKKGFDKPLPAPPPIGES--HGLDESLIRNSITLKAQANKSRTSTN 1329
              ..:|.||   :.|:.::..|         |.:.::  :||:.|.:.|.    |.|:|
  Rat   478 RCDYLDEKG---IETYLIIASK---------PEVKKTAQNGLNGSALPNG----APASK------ 520

  Fly  1330 PSSSQSSSLAGESVEVKVEITPPTNADLASGTNLPNSYSLDSNSTNTISPNATLCPEFPGKTTPS 1394
            |||           ...:|...|..:..|||:....:...::.:.|         |.||   .|.
  Rat   521 PSS-----------PALIETKEPNGSAHASGSTSEEAEEQEAQADN---------PSFP---NPR 562

  Fly  1395 -------------STSPQSRKLSELTPENLLNPNS 1416
                         ..|....:|::|..|.||...|
  Rat   563 RRLRLQDLADRVVDASEDEHELNQLLNEALLERES 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	30/144 (21%)
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	64/204 (31%)
Adcy3	NP_570135.2	AC_N	<44..303	CDD:318454	45/210 (21%)
		Guanylate_cyc	310..494	CDD:306677	61/190 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..563		20/91 (22%)
		Guanylate_cyc	914..1121	CDD:306677
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900