DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34357 and gucy2ca

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	XP_009297342.1	Gene:	gucy2ca / 572052	ZFINID:	ZDB-GENE-091118-67	Length:	1025	Species:	Danio rerio

Alignment Length:	1093	Identity:	321/1093 - (29%)
Similarity:	472/1093 - (43%)	Gaps:	273/1093 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   317 LALDFNKTVVLWPCPRMKISSNFLPSFEAISLAVQSISTKLNWSQVDIYIGDDN-----WGLGLA 376
            |:.|:.:.:.....|..||:..|   |.....:|:::  |..|....:|..|:.     |.:..
Zfish   147 LSCDYKQKLTRLLPPARKIAEFF---FHFWHTSVKNL--KPAWKTAYVYKKDNYTEECFWYINA- 205

  Fly   377 IAANLHVPYRIEIGRTIRD-----------LHSQDKPGKAIIITAPLNDASTILLLSTIELDWTE 430
                |..|..:......|:           |..:|:....|::....:|..||...:|:.
Zfish   206 ----LEAPSALFSSNISREMLRSESELSTALKRKDRHSNIIVMCGTPDDIYTIKKNNTVP----- 261

  Fly   431 QARKDGQGSRPGRQHTKILLIDMAASSLDTQHGFYKYLSRMGGSQSDAFARNTGSPAEVVSSNLL 495
                         .....:|||:                     .::.:..|..|||.:  .|:|
Zfish   262 -------------SQVVFILIDL---------------------YNEGYRTNESSPAHM--RNVL 290

  Fly   496 VLTLLNDRHRLFLNAAGLMATMQNFRAPLNGNYKDPPPSGHRNASLHKL-----YPYRNLLPLYD 555
            |||:     ..|.|.:.......|....:.|.|| ...||.|:.:|..:     |.||.|.. :|
Zfish   291 VLTM-----HSFRNYSSNSVWRNNTTVSIGGYYK-LDSSGDRDLNLSVVYTTGSYKYRTLFS-FD 348

  Fly   556 TIVTTTTQSDTSETSPQFDFVVLDIVRDAPVATYKWRPLLILESDPGSRGGGSVVEGGGSYISHS 620
            |....|...|:|...|                   |                     ..|.:...
Zfish   349 TSQNRTKVKDSSPDLP-------------------W---------------------DRSQLPRD 373

  Fly   621 IHPGYDEWLLVSSVLLWQCGAICWTIAAICVCLLVIMIAGIVAGGIAMRNYFLRKRLSKGPNKIV 685
            .|.|.:    :..::                 ::|:.::.::|..||...|...:|:.....|..
Zfish   374 KHTGME----IQEIM-----------------MIVLGLSVVLATVIAFILYRQNRRVRFDQKKWS 417

  Fly   686 LSASDFVFPVDSRR-------VDEGIEAMLCCWLQQLQEFGGPEVDKPDLLKGSIGSLKNLGFVI 743
            ..:|..:.|:|.:.       :||                     ||    ||...||...|
Zfish   418 HISSSLITPLDDKERNYISLTIDE---------------------DK----KGDNSSLIRKG--- 454

  Fly   744 PGAAAPGSAGAITTTANGKSGSSATGSLARHNPAHLDMRARYNGDLVQLKEV-NING--SAELRT 805
                                                    ||:...|.|||: |.:|  :.:.|.
Zfish   455 ----------------------------------------RYDKKPVILKELRNTDGNFTDDQRI 479

  Fly   806 KAMDLLVMAHGLRHENINPLIGWLSDPNRTAMVFDYCSRGSLQDVLIMDEIK------LDWSFRL 864
            :...||    .:.:.|:....|.:........||::|.||||:.|| .|:|.      :|..||:
Zfish   480 ELNALL----RIDYYNLTKFYGTVRFDCGVFGVFEFCERGSLRYVL-DDKISYPDASFMDLEFRI 539

  Fly   865 SLLTDLVRGMRYLHTSPLRVHGALTSRNCVVDARWVLKITDYGLNSFYESQGLPPRTRSAKELLW 929
            |::.|:.:||.|||:|.:.|||.|.|.|||||.|.|:||||:|.|:.     |.|    .|: ||
Zfish   540 SVMYDIAKGMSYLHSSNVGVHGRLKSTNCVVDNRMVVKITDFGCNTI-----LSP----GKD-LW 594

  Fly   930 TAPELLRNMKLHQHHHQHGRIQLGTQLGDVYSFGIIMQEVVVRGEPY---CMLSLSPEEIIVKIK 991
            ||||             |.|::..:|.||||||.||.||:::|..|:   |...::.:..:|:..
Zfish   595 TAPE-------------HMRVEGISQKGDVYSFAIISQEIILRKSPFHTSCCSDMAEKLYLVQYP 646

  Fly   992 KPPPLIRPSVS---KGAAPPEAINIMRQCWAEQPDMRPDFNSVY----ERFKMLNHGRKVNFVDT 1049
            :.|.:.||.:|   .|....|...:::.||.|.|:.||||..:.    :.|..|::....:::|.
Zfish   647 RGPNVFRPDLSFEGVGETEAELFVLIKSCWEEDPEKRPDFKRIEGALGKIFSNLHNQANASYMDN 711

  Fly  1050 MFQMLEKYSNNLEELIRERTEQLDIERKKTEQLLNRMLPSSVAEKLKMGLAVDPEEFSDVTIYFS 1114
            :.:.|:.||.|||.|:.|||.....||.:.:||...:||..|...||....|:||.:.:||||||
Zfish   712 LIRRLQMYSRNLEHLVEERTALYKAERDRADQLNFMLLPGPVVRSLKETGRVEPELYDEVTIYFS 776

  Fly  1115 DIVGFTTIAAHCSPVQVVDLLNDLYTIFDATINAYNVYKVETIGDAYMVVSGLP-VKIPDHAEQI 1178
            ||||||||..|.:|::|||:|||:|..||:.::.::|||||||||||||.|||| .....||..|
Zfish   777 DIVGFTTICHHSTPMEVVDMLNDIYKNFDSILDHHDVYKVETIGDAYMVASGLPRCNGNRHAVDI 841

  Fly  1179 ATMALDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGS 1243
            ..||||:|...|.|.::||||:||.:|||:|:|||.|||||..|||||||||||||||||||||.
Zfish   842 CLMALDILEFMGTFQLRHLPGIPLWIRIGIHSGPCAAGVVGNKMPRYCLFGDTVNTASRMESTGL 906

  Fly  1244 SWRIHMSQET---RDRLDARGGYAIEPRGLIDIKGKGMMNTFWLLGKKGFDKPLPAPPPIGESHG 1305
            ..|||:|:.|   ..|.|..  :..|.||...:||||...|:||.|..|....||.||.:.....
Zfish   907 PLRIHVSESTIKILQRTDCE--FECERRGETFLKGKGKEMTYWLTGVTGQKYSLPTPPTVENFQR 969

  Fly  1306 LDESLIRNSI-TLKAQANKSR----TSTNPSSSQSSSLAGESVEVKVEITPPT 1353
            |.:.|....: ||..:.|:.|    |....:.:...:.:|:.....:.:|.||
Zfish   970 LQQDLAERIVSTLNKRGNERRKTLSTRQRRTHTHIHTHSGDGQPEYLHLTDPT 1022

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	95/296 (32%)
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	110/195 (56%)
gucy2ca	XP_009297342.1	Periplasmic_Binding_Protein_Type_1	31..365	CDD:299141	55/294 (19%)
		PKc_like	428..698	CDD:304357	103/365 (28%)
		Pkinase_Tyr	451..689	CDD:285015	94/308 (31%)
		CYCc	736..929	CDD:214485	110/194 (57%)
		Guanylate_cyc	763..950	CDD:278633	111/188 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920