DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34357 and adcy1b

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	NP_001161822.1	Gene:	adcy1b / 569499	ZFINID:	ZDB-GENE-100805-1	Length:	1114	Species:	Danio rerio

Alignment Length:	353	Identity:	99/353 - (28%)
Similarity:	159/353 - (45%)	Gaps:	69/353 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  1059 NNLEELIRERTEQLDIERKKTEQLLNRMLPSSVAEKLKMGLAVDPEEF---------SDVTIYFS 1114
            |.:||.:|     ::.|.:|.|:||..:||.:||.::|......||..         .:|:|.|:
Zfish   226 NCIEERLR-----MEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFA 285

  Fly  1115 DIVGFTTIAAHCSPVQVVDLLNDLYTIFDATINAYNVYKVETIGDAYMVVSGLPVKIPDHAEQIA 1179
            ||||.|::|:.|:..::|.|||:|:..||......:..:::.:||.|..||||.....|||....
Zfish   286 DIVGSTSLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCV 350

  Fly  1180 TMALDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGSS 1244
            .|.||::...  .:|.....|.|.:|:|||||....||:||...:|.::.:.|..|:.||:.|..
Zfish   351 EMGLDMIDTI--TSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANMMEAGGLP 413

  Fly  1245 WRIHMSQETRDRLDARGGYAIEP-----------------------------RGLI--DIKGKGM 1278
            .::|:::.|.:.|:  |.|.:||                             .|||  |||....
Zfish   414 GKVHITRSTLECLN--GDYEVEPGNGRERHAFLLKHDIETFFIVPPHRRKIFPGLILSDIKPAKK 476

  Fly  1279 M---NTFWLL-----GKKGFDKPLPAPPPIGESHGLDESLIRNSITLKAQANKSRTSTNPSSSQS 1335
            |   ...:||     .:|.|...:|....:....|....::|::    .:..::||.|..|:.||
Zfish   477 MKFKTVCYLLVQLMHCRKMFRAEIPFSNVMNCEDGDKRRVLRSA----PEKLRNRTPTAASAPQS 537

  Fly  1336 SSLAGESVE------VKVEITPPTNADL 1357
            |  .|..|.      ::...|....|||
Zfish   538 S--PGTRVNRYINRLIEARQTESDTADL 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	66/200 (33%)
adcy1b	NP_001161822.1	AC_N	<128..270	CDD:292831	16/48 (33%)
		CYCc	236..431	CDD:214485	65/198 (33%)
		Guanylate_cyc	272..454	CDD:278633	56/185 (30%)
		DUF1053	498..585	CDD:283888	16/72 (22%)
		CYCc	806..1012	CDD:214485
		Guanylate_cyc	839..1035	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900