DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34357 and adcy7

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	XP_021333246.1	Gene:	adcy7 / 568726	ZFINID:	ZDB-GENE-040713-1	Length:	1119	Species:	Danio rerio

Alignment Length:	427	Identity:	120/427 - (28%)
Similarity:	195/427 - (45%)	Gaps:	73/427 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  1071 QLDIERKKTEQLLNRMLPSSVAEKLKMGL-----AVDPEE-----------------FSDVTIYF 1113
            :|:||:::.|.||..:||..::.|:|:.:     ..|.||                 ..:|:|.:
Zfish   220 KLEIEKRQQENLLQSVLPVYISMKMKLAIMERCKCKDKEEQQRMVRDNNFHSLYVKRHENVSILY 284

  Fly  1114 SDIVGFTTIAAHCSPVQVVDLLNDLYTIFDATINAYNVYKVETIGDAYMVVSGLPVKIPDHAEQI 1178
            :||||||.:|:.|||.::|.:||:|:..||.........:::.:||.|..||||||.:|:||:..
Zfish   285 ADIVGFTRLASDCSPKELVLMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPVSLPNHAKNC 349

  Fly  1179 ATMALDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGS 1243
            ..|.||:.....:  |:...||.:.:|:|:|:|....||:||...::.::...|..|:.|||.|.
Zfish   350 VKMGLDMCEAIKQ--VREATGVDINMRVGVHSGNVLCGVIGLRKWQFDVWSHDVTLANHMESGGL 412

  Fly  1244 SWRIHMSQETRDRLDARGGYAIEPRGLIDIKGKGMMNTFWL--LGKKGFDKPLPAPPPIGESHGL 1306
            ..|:|:::.|...|:.  .|.:|       :|.|.:...:|  |..|.|   |...|     ...
Zfish   413 PGRVHITEATLKHLNK--AYEVE-------EGNGHLRDTYLKELNIKTF---LVIDP-----RSK 460

  Fly  1307 DESLIRNSITLKAQANKSRTSTNPSSSQSSSLAGESVEVKVEITPPTNADLAS-GTNLPNSY--S 1368
            |.||:..|||      |.|.|.           |..:...|.:|    ..|.| |...|.::  |
Zfish   461 DSSLMAPSIT------KPRVSD-----------GLKMRASVRMT----RFLESWGAVKPFAHLQS 504

  Fly  1369 LDSNSTNTISPNATLCPEFPGKTTPSSTSPQSRKLSELTPENLLNP--NSFNRLPSSTGGSSSRL 1431
            .:..:|:.:......|.:.|.::.|:. :|.|...|...|.:|..|  :::||..|........|
Zfish   505 REEFNTDAMVNGKGHCKDIPLRSVPTH-NPDSFDESLEEPFSLPAPPLSTYNRNKSQKTKFDEEL 568

  Fly  1432 YKKIEEMM-DLSSPYNHYKCLSPSESNLTQFYDGKYL 1467
            :.|:...: ||||.....|  |...|.||.::..|.|
Zfish   569 HDKMTTTINDLSSSKQWVK--SEEISGLTLWFTKKDL 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	67/213 (31%)
adcy7	XP_021333246.1	AC_N	<129..248	CDD:318454	10/27 (37%)
		Guanylate_cyc	272..455	CDD:306677	63/196 (32%)
		DUF1053	487..613	CDD:310728	32/124 (26%)
		Guanylate_cyc	909..1106	CDD:306677
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900