DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34357 and adcy5

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	NP_001165056.1	Gene:	adcy5 / 562619	ZFINID:	ZDB-GENE-081104-470	Length:	1186	Species:	Danio rerio

Alignment Length:	392	Identity:	96/392 - (24%)
Similarity:	171/392 - (43%)	Gaps:	80/392 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1075 ERKKTEQLLNRMLPSSVAEKLKMGLAVDPEEF----------SDVTIYFSDIVGFTTIAAHCSPV 1129
            |.::.|:||..:||..||.::|..:....|:.          .:|:|.|:||.|||::|:.|:..
Zfish   354 ENQQQERLLLSVLPRHVALEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQ 418

  Fly  1130 QVVDLLNDLYTIFDATINAYNVYKVETIGDAYMVVSGLPVKIPDHAEQIATMALDLLHQSGRFNV 1194
            ::|..||:|:..||......:..:::.:||.|..|||||....|||.....|.:|::.....  |
Zfish   419 ELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISL--V 481

  Fly  1195 KHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGSSWRIHMSQETRDRLDA 1259
            :.:.||.:.:|:|:|:|....||:||...::.::.:.|..|:.||:.|.:.|||:::.|.:.|:
Zfish   482 REVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLN- 545

  Fly  1260 RGGYAIEPRGLIDIKGKGMMNTFWLLGKKGFDKPLPAPPPIGESHGLDESLI-------RNSITL 1317
             |.|.:||       |.|.....:|                 :.|.::..||       :....:
Zfish   546 -GDYDVEP-------GSGGERNVYL-----------------KKHNIETYLIVGCSQKRKEEKAM 585

  Fly  1318 KAQANKSRTSTNPSSSQS-------SSLAGESVEVKVEITPPTNADLASGTNLPNSYSLDSNSTN 1375
            .|:.|:.||::...:|..       :.|...||..:::         ..|...|.    |.|:..
Zfish   586 IAKMNRQRTNSVTHNSTHWTDRPFYNHLNANSVSKEMK---------RMGFEDPK----DKNTQE 637

  Fly  1376 TISPNATLCPEFPGKTTPSSTSPQSRKLSELTPENLLNPNSFNRLPSSTGGSSSRLYKKIEEMMD 1440
            .::|...: .||.|:..      .:|.:..|..|::.......|.|.        |.||..:.:|
Zfish   638 NLNPEDEV-DEFLGRAI------DARSIDRLRSEHVKKFLLTFREPD--------LEKKYSKQVD 687

  Fly  1441 LS 1442
            .|
Zfish   688 SS 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	62/200 (31%)
adcy5	NP_001165056.1	AC_N	1..388	CDD:292831	10/33 (30%)
		CYCc	354..548	CDD:214485	61/197 (31%)
		Guanylate_cyc	390..574	CDD:278633	60/211 (28%)
		DUF1053	598..687	CDD:283888	20/116 (17%)
		CYCc	961..1155	CDD:214485
		Guanylate_cyc	987..1181	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900