DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34357 and adcy2b

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	XP_005170095.1	Gene:	adcy2b / 557902	ZFINID:	ZDB-GENE-060503-69	Length:	1142	Species:	Danio rerio

Alignment Length:	427	Identity:	103/427 - (24%)
Similarity:	187/427 - (43%)	Gaps:	77/427 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly  1057 YSNNLEELIRERTE-----------QLDIERKKTEQLLNRMLPSSVAEKLKMGL----------- 1099
            |..:|.:|..::|.           :|:.|:.:.|:||..:||:.:|..:|..:
Zfish   254 YHKHLMDLALKQTYHDTCNCIKSPIKLEFEKHQQERLLLSLLPAHIARVMKAEIIQRLKGPNFSQ 318

  Fly  1100 AVDPEEF--------SDVTIYFSDIVGFTTIAAHCSPVQVVDLLNDLYTIFDATINAYNVYKVET 1156
            |.:...|        ::|:|.::||||||.:|:.|||.::|.:||:|:..||......:..:::.
Zfish   319 AENTNNFHNLYVQRHTNVSILYADIVGFTRLASDCSPGELVYMLNELFGKFDQIAKDNDCMRIKI 383

  Fly  1157 IGDAYMVVSGLPVKIPDHAEQIATMALDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGLT 1221
            :||.|..|||||..:.|||:....|.||:.....:  |:...||.:.:|:|:|:|....||:||.
Zfish   384 LGDCYYCVSGLPDPLLDHAKNCVKMGLDMCEAIEK--VREATGVDINMRVGVHSGNVLCGVIGLQ 446

  Fly  1222 MPRYCLFGDTVNTASRMESTGSSWRIHMSQETRDRLDARGGYAIEPRGLIDIKGKGMMNTFWLLG 1286
            ..:|.::...|..|:.||:.|...|:|:|..|.:.|:  |.|.:|       :|.|.....:|
Zfish   447 KWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLN--GAYKVE-------QGNGQSRDSYL-- 500

  Fly  1287 KKGFDKPLPAPPPIGESHGLDESLIRNSITLKAQANKSRTSTNPSSSQSSSLAGESVEVKVEITP 1351
                           :.||:...|:.|.   ||:    :.|....|:...::.|..:...|.:|.
Zfish   501 ---------------KEHGIVTYLVINP---KAE----KRSPLLLSAIRPTMYGAKMRASVRMTQ 543

  Fly  1352 PTNADLASGTNLPNSYSLDS--NSTNTISPNATLCPEFPGKTTPSSTSPQSRKLSELTPENLLNP 1414
            ...: ..:.....|.:..||  |....|:.......::..:.....|..|.::..|...|.::.
Zfish   544 YLES-WGAAKPFANLHHRDSMTNENGMINTRDVPLGQYNCQQRSERTKSQKKRFEEELNERIIR- 606

  Fly  1415 NSFNRLPSSTGGSSSRLYKKIEEMMDLSSPYNHYKCL 1451
                   :..|.:|.:.:.|.|::..:|. :.|.|.|
Zfish   607 -------TIDGINSQKQWLKSEDIQRISL-FFHNKAL 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	66/210 (31%)
adcy2b	XP_005170095.1	AC_N	<80..307	CDD:292831	13/52 (25%)
		CYCc	283..486	CDD:214485	65/206 (32%)
		Guanylate_cyc	328..512	CDD:278633	63/211 (30%)
		DUF1053	542..646	CDD:283888	18/104 (17%)
		CYCc	899..1106	CDD:214485
		Guanylate_cyc	929..1128	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900