DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34357 and gucy1b2

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	XP_685297.5	Gene:	gucy1b2 / 557191	ZFINID:	ZDB-GENE-130530-664	Length:	757	Species:	Danio rerio

Alignment Length:	357	Identity:	143/357 - (40%)
Similarity:	197/357 - (55%)	Gaps:	45/357 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly  1058 SNNLE---ELIRERTEQLDIERKKTEQLLNRMLPSSVAEKLKMGLAVDPEEFSDVTIYFSDIVGF 1119
            ||.||   |.:|..:..|:||::|:|:||..|||:.||.:||.|..|:..||...||.|||:|.|
Zfish   413 SNQLERKKEELRILSRNLEIEKQKSEKLLYAMLPTHVANQLKEGKRVEAGEFKVCTILFSDVVTF 477

  Fly  1120 TTIAAHCSPVQVVDLLNDLYTIFDATINAYNVYKVETIGDAYMVVSGLPVKIPDHAEQIATMALD 1184
            |.|.|.|.|:|:|::||.:|:.||...:.:|||||||||||||||.|:||....|||::|..||.
Zfish   478 TNICAACEPIQIVNMLNAMYSRFDRLTSIHNVYKVETIGDAYMVVGGVPVPTNTHAERVANFALG 542

  Fly  1185 LLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGSSWRIHM 1249
             :..:.|.....:.|.|:|:|:||||||..|||||..|||||||||||||||||||.|....||:
Zfish   543 -MRIAAREVTNPITGQPIQIRVGLHTGPVLAGVVGEKMPRYCLFGDTVNTASRMESHGVPDHIHV 606

  Fly  1250 SQETRDRLDARGGYAIEPRGLIDIKGKGMMNTFWLLGKKGFDKPLPAPPPI-----GESHGLDES 1309
            |..|...:..:|.:.:..||.|::||||:|.|::||  |...|   :...|     ||.....|.
Zfish   607 SPFTFSVIKDKGIFEMAERGEIEVKGKGLMRTYFLL--KNLQK---SDEQIMGLVDGEMCVYQED 666

  Fly  1310 LIRNSITLK---------------------AQANKSRTS-TNPSSSQSSSLAGESVEVKVEITPP 1352
            |...:..||                     |:...:.|| .:|||..|...:.:.: ::.:|||.
Zfish   667 LEEETDDLKEVSPEDMNAVLKVEEDAHKEVAENGNNHTSPPSPSSLHSDKSSSDHL-IQFDITPA 730

  Fly  1353 TNADLASGTNLPNSYSLDSNSTNTISPNATLC 1384
            .::        ||.:....|..::...|...|
Zfish   731 YDS--------PNDFKHLHNGHHSDGINTKFC 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	101/191 (53%)
gucy1b2	XP_685297.5	HNOB	2..163	CDD:285002
		CAF-1_p150	<166..277	CDD:288454
		HNOBA	269..453	CDD:285003	18/39 (46%)
		CYCc	432..618	CDD:214485	100/186 (54%)
		Guanylate_cyc	459..642	CDD:278633	96/183 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810