DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34357 and npr1b

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	XP_009290669.2	Gene:	npr1b / 555911	ZFINID:	ZDB-GENE-100805-4	Length:	1070	Species:	Danio rerio

Alignment Length:	913	Identity:	308/913 - (33%)
Similarity:	447/913 - (48%)	Gaps:	188/913 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   449 LLIDMAASSLDTQHGFYKYLSRMG-------------GSQSDAFARNTGSPAEVVS----SNL-- 494
            |::....:.|..:...:.|:...|             |...|.||:......::::    .|.
Zfish   267 LIVHFHKAGLPKEEYVFFYIDIFGHSFRSRPSQPWARGDSDDVFAKEAFQSVKILTYLEPQNQEY 331

  Fly   495 --LVLTLLNDRHRLF--------LNAA------GLMATMQNFRAPLNGNYKDPPPSGHRNASLHK 543
              .|..|.:|..|:|        :|..      |||.........|:.:::.|..........::
Zfish   332 KDFVTDLKSDAKRMFNFTVDDSLMNIISGGFYDGLMLYCHALNESLSDSHERPSGESVSKRMWNR 396

  Fly   544 LYPYRNLLPLYDTIVTTTTQSDTS---ETSPQFDFVVLDIVRDAPVATYKWRPLLILESDPGSRG 605
            .|        |.  ||...|.|.:   ||    ||.:.|:   |.:.|..::.:.:.
Zfish   397 TY--------YG--VTGLVQIDENGDRET----DFALWDM---ADINTGDFQIVAVY-------- 436

  Fly   606 GGSVVEGGGSYISHSIHPGYDEWLLVSSVLLWQCGAI------CW-----------TIA---AIC 650
                   .|:....:|.||        ..:.|..|.:      |.           |||   .|.
Zfish   437 -------NGTQKEMNILPG--------MAIQWPGGKVPMDVPTCGFKNENPACRARTIAMHQMIS 486

  Fly   651 VCLLVIMIAGIVAGGIAMRNYFLRKRLSKGPNKIVLSASDFVFPVDSRRVDEGIEAMLCCWLQQL 715
            :.|.:|:|                         |:.:.:.|::    |::.  :|..|   :.||
Zfish   487 IVLFLILI-------------------------IIFTVTVFIY----RKLK--LEKEL---VAQL 517

  Fly   716 QEFGGPEVDKPDLLKGSIGSLKNLGFVIPGAAAPGSAGAITTTANGKSGSSATGSLARHNPAHLD 780
            ......::....|.|    :|::.|..:..:....:.|::.||.......:.||
Zfish   518 WRISWDDIQMSHLEK----ALRSTGSKLTLSLRGSNYGSLLTTDGNFQVFAKTG----------- 567

  Fly   781 MRARYNGDLVQLKEVNINGSAELRTKAMDLLVMAHGLRHENINPLIGWLSDPNRTAMVFDYCSRG 845
               .:.|::|.:|.:| ....||..|.:..|.....:::|::...||...||....:|.:||.||
Zfish   568 ---YFKGNIVAIKYIN-RRRVELTRKVLFELKHMRDVQNEHLTRFIGACIDPPNICIVTEYCPRG 628

  Fly   846 SLQDVLIMDEIKLDWSFRLSLLTDLVRGMRYLHTSPLRVHGALTSRNCVVDARWVLKITDYGLNS 910
            |||::|..|.|.|||.|:.||::|:|:||.:||.|.:..||.|.|.|||||.|:|||||||||:|
Zfish   629 SLQNILENDSITLDWMFKYSLISDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSS 693

  Fly   911 FYESQGLPPRTRSAKE--------LLWTAPELLRNMKLHQHHHQHGRIQL----GTQLGDVYSFG 963
            .        ||.|..|        .||.||||             .|::.    |||.|||||||
Zfish   694 I--------RTESDTEDAHSYYARKLWLAPEL-------------SRMECFPPGGTQKGDVYSFG 737

  Fly   964 IIMQEVVVRGEPYCMLS--LSPEEIIVKIKKPP-PLIRPSVSKGAAPPEAINIMRQCWAEQPDMR 1025
            ||:|||.:|...:.:..  |||:||:.::.... |.:|||::..|...|...:|::||||:|..|
Zfish   738 IILQEVALRRGVFYLEGDLLSPKEIVDRVALGEWPYLRPSLNPQAHSEELGQLMQRCWAEEPSDR 802

  Fly  1026 PDFNSVYERFKMLNHGRKVNFVDTMFQMLEKYSNNLEELIRERTEQLDIERKKTEQLLNRMLPSS 1090
            |:|:.:....:..|...:.|.:|.:...:|:|:||||||:.|||:....|::|.|.||.::||.|
Zfish   803 PEFSHISVLLRKQNREHRSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHS 867

  Fly  1091 VAEKLKMGLAVDPEEFSDVTIYFSDIVGFTTIAAHCSPVQVVDLLNDLYTIFDATINAYNVYKVE 1155
            |||:||.|..|..|.|..||||||||||||:::|..:|:|||.|||||||.|||.|:.::|||||
Zfish   868 VAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVE 932

  Fly  1156 TIGDAYMVVSGLPVKIPD-HAEQIATMALDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVG 1219
            ||||||||||||||:... |..:||.|:|.||.....|.::|.|...|:||||:|:||.||||||
Zfish   933 TIGDAYMVVSGLPVRNGKLHGREIARMSLALLEAVKTFKIRHRPDEQLKLRIGIHSGPVCAGVVG 997

  Fly  1220 LTMPRYCLFGDTVNTASRMESTGSSWRIHMSQETRDRLDARGGYAIEPRGLIDIKGKGMMNTFWL 1284
            |.|||||||||||||:|||||.|...:||:|..||..|.....:.:|.||.:::||||.|.|:||
Zfish   998 LKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSATRAVLQEFNCFQLELRGDVEMKGKGKMRTYWL 1062

  Fly  1285 LGK 1287
            ||:
Zfish  1063 LGE 1065

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	107/292 (37%)
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	114/192 (59%)
npr1b	XP_009290669.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820