DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34357 and gucy1a1

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	NP_001296458.1	Gene:	gucy1a1 / 550420	ZFINID:	ZDB-GENE-050417-230	Length:	679	Species:	Danio rerio

Alignment Length:	525	Identity:	146/525 - (27%)
Similarity:	232/525 - (44%)	Gaps:	103/525 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   841 YCSRGSLQ-DVLIMDEIKLDWSFRLSLL-TDLVRGMRYLHTSPLRVHGALTSRNCVVDARWVLKI 903
            ||:|..:: ||...|...|....:..|| :.:||..|.|..||:|.|   ||
Zfish   228 YCTRVEVRMDVGGKDSGALQADHQPHLLYSVVVRDGRSLTPSPMRTH---TS------------- 276

  Fly   904 TDYGLNSFYESQGLPPRTRSAKELLWTAPELLRNMKLHQHHHQHGRIQLGTQLGDVYS--FGIIM 966
            .|..|:..|.:............||.....|.|.:         ||.:.| |....::  |.|:.
Zfish   277 GDIPLSLLYSTFPFHILLDQEMGLLQIGDGLRRRL---------GRCRDG-QRRPAFNEHFAIVS 331

  Fly   967 QEVVVRGEPYCMLSLSPEEIIVKIKKPPPLIRPSVSKGAAPPEAINIMRQ--------------- 1016
            .|  :|.....:|::...:.::::|      :...|...:|.:.:::..|
Zfish   332 PE--IRASFQDILTMLNTQFLLRVK------QHGASSADSPGKHMDLKGQMIFMSEMSALLFLGS 388

  Fly  1017 -CWAEQPDMR---------PDFNSVYERFKMLNHGRKVNFVDTMFQMLEKYSNNLEELIRERTEQ 1071
             |..:..::.         |..|::.:   ::..|.:....|.:.:.|.|....||    :..:.
Zfish   389 PCVDKLEELTGRGLYLSDIPIHNALRD---VVLVGEQTKAQDGLKKRLGKAKAALE----QAHQA 446

  Fly  1072 LDIERKKTEQLLNRMLPSSVAEKLKMGLAVDPEEFSDVTIYFSDIVGFTTIAAHCSPVQVVDLLN 1136
            |:.|:::|.:||..:.|.:||::|..||.|..::|..||:.||||||||.|.:.|:|:|||::|:
Zfish   447 LEEEKRRTVELLFTIFPGNVAQRLWQGLPVQAKKFDHVTVLFSDIVGFTAICSRCTPMQVVNMLS 511

  Fly  1137 DLYTIFDATINAYNVYKVETIGDAYMVVSGLPVKIPDHAEQIATMALDLLHQSGRFNVKHLPGVP 1201
            :|||.||......:|||||||||||.|..||..:.|.||.|||.|||.::..|.  .|....|..
Zfish   512 ELYTRFDHHCGELDVYKVETIGDAYCVAGGLHKESPTHAVQIALMALKMMELSD--EVTTPMGEV 574

  Fly  1202 LQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGSSWRIHMSQETRDRLDARGGYAIE 1266
            :::|||:|:|...|||||:.||||||||:.|..|::.||.....:|::|..|...|.....:.:.
Zfish   575 IRMRIGIHSGSVLAGVVGVKMPRYCLFGNNVTLANKFESCSLPRKINVSPTTYRLLKDCPEFTLI 639

  Fly  1267 PRGLIDIKGKGMMNTFWLLGKKGFDKPLPAPPPIGESHGLDESLIRNSITLKAQANKSRTSTNPS 1331
            ||...|:             ...|...:|                  .:....||:..:|:..|.
Zfish   640 PRTREDL-------------PPNFPTDIP------------------GVCYFLQAHDQKTNAAPE 673

  Fly  1332 SSQSS 1336
            .:|.|
Zfish   674 ETQPS 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	42/228 (18%)
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	86/191 (45%)
gucy1a1	NP_001296458.1	HNOBA	279..470	CDD:285003	36/215 (17%)
		CYCc	449..635	CDD:214485	86/187 (46%)
		Guanylate_cyc	476..647	CDD:278633	79/185 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810