Protein Alignment CG34357 and gucy1a1

DIOPT Version :10

• Sequence 1: NP_001356914.1
• Gene: CG34357 / 5740349
• FlyBaseID: FBgn0085386
• Length: 1689
• Species: Drosophila melanogaster
• Sequence 2: NP_001296458.1
• Gene: gucy1a1 / 550420
• ZFINID: ZDB-GENE-050417-230
• Length: 679
• Species: Danio rerio
• Alignment Length: 525
• Identity: 146/525 - (27%)
• Similarity: 232/525 - (44%)
• Gaps: 103/525 - (19%)

  Fly   841 YCSRGSLQ-DVLIMDEIKLDWSFRLSLL-TDLVRGMRYLHTSPLRVHGALTSRNCVVDARWVLKI 903
            ||:|..:: ||...|...|....:..|| :.:||..|.|..||:|.|   ||
Zfish   228 YCTRVEVRMDVGGKDSGALQADHQPHLLYSVVVRDGRSLTPSPMRTH---TS------------- 276

  Fly   904 TDYGLNSFYESQGLPPRTRSAKELLWTAPELLRNMKLHQHHHQHGRIQLGTQLGDVYS--FGIIM 966
            .|..|:..|.:............||.....|.|.:         ||.:.| |....::  |.|:.
Zfish   277 GDIPLSLLYSTFPFHILLDQEMGLLQIGDGLRRRL---------GRCRDG-QRRPAFNEHFAIVS 331

  Fly   967 QEVVVRGEPYCMLSLSPEEIIVKIKKPPPLIRPSVSKGAAPPEAINIMRQ--------------- 1016
            .|  :|.....:|::...:.::::|      :...|...:|.:.:::..|
Zfish   332 PE--IRASFQDILTMLNTQFLLRVK------QHGASSADSPGKHMDLKGQMIFMSEMSALLFLGS 388

  Fly  1017 -CWAEQPDMR---------PDFNSVYERFKMLNHGRKVNFVDTMFQMLEKYSNNLEELIRERTEQ 1071
             |..:..::.         |..|::.:   ::..|.:....|.:.:.|.|....||    :..:.
Zfish   389 PCVDKLEELTGRGLYLSDIPIHNALRD---VVLVGEQTKAQDGLKKRLGKAKAALE----QAHQA 446

  Fly  1072 LDIERKKTEQLLNRMLPSSVAEKLKMGLAVDPEEFSDVTIYFSDIVGFTTIAAHCSPVQVVDLLN 1136
            |:.|:::|.:||..:.|.:||::|..||.|..::|..||:.||||||||.|.:.|:|:|||::|:
Zfish   447 LEEEKRRTVELLFTIFPGNVAQRLWQGLPVQAKKFDHVTVLFSDIVGFTAICSRCTPMQVVNMLS 511

  Fly  1137 DLYTIFDATINAYNVYKVETIGDAYMVVSGLPVKIPDHAEQIATMALDLLHQSGRFNVKHLPGVP 1201
            :|||.||......:|||||||||||.|..||..:.|.||.|||.|||.::..|.  .|....|..
Zfish   512 ELYTRFDHHCGELDVYKVETIGDAYCVAGGLHKESPTHAVQIALMALKMMELSD--EVTTPMGEV 574

  Fly  1202 LQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGSSWRIHMSQETRDRLDARGGYAIE 1266
            :::|||:|:|...|||||:.||||||||:.|..|::.||.....:|::|..|...|.....:.:.
Zfish   575 IRMRIGIHSGSVLAGVVGVKMPRYCLFGNNVTLANKFESCSLPRKINVSPTTYRLLKDCPEFTLI 639

  Fly  1267 PRGLIDIKGKGMMNTFWLLGKKGFDKPLPAPPPIGESHGLDESLIRNSITLKAQANKSRTSTNPS 1331
            ||...|:             ...|...:|                  .:....||:..:|:..|.
Zfish   640 PRTREDL-------------PPNFPTDIP------------------GVCYFLQAHDQKTNAAPE 673

  Fly  1332 SSQSS 1336
            .:|.|
Zfish   674 ETQPS 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	Protein Kinases, catalytic domain	763..1041	CDD:473864	42/228 (18%)
		HNOBA	<1047..1095	CDD:462234	13/47 (28%)
		CYCc	1074..1266	CDD:214485	86/191 (45%)
gucy1a1	NP_001296458.1	HNOBA	279..470	CDD:462234	36/215 (17%)
		Guanylate_cyc	476..647	CDD:425528	79/185 (43%)