DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34357 and Phlpp2

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	NP_001102601.2	Gene:	Phlpp2 / 498949	RGDID:	1562857	Length:	1359	Species:	Rattus norvegicus

Alignment Length:	1240	Identity:	221/1240 - (17%)
Similarity:	355/1240 - (28%)	Gaps:	523/1240 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 FGLSPTFA--SASASSSLSSSSSSSSHFH-----SEKP----------------LHSDVLVLRAA 72
            :|...|.|  :.::|||.||||||||..|     .|.|                ||.| ||.|..
  Rat    71 YGADTTTATTTTTSSSSSSSSSSSSSDLHLVLCTVETPASEICAGEGRESLYLQLHGD-LVRRLE 134

  Fly    73 KPSRAIATSADAATR-------SVPASAAETTL-------GSKSI-------------------- 103
            ...|.:....|..:|       .:...|....|       |.|..
  Rat   135 PTERPLQIVYDYLSRLGFEDPVRIQEEATNPDLSCMIRFYGEKPCQMDHLDRILLSGIYNVRKGK 199

  Fly   104 -----WP--------TAIQTKSPRNAREAGRH------------KRQMQKPAIQQQPLQQQQQRI 143
                 |.        |.:...|.::.:....|            ||:....|......|.|...:
  Rat   200 TQLHKWAERLVVLCGTCLIVSSVKDCQTGKMHILPLVGGKIEEVKRRQHSLAFSSAGAQAQTYHV 264

  Fly   144 NPPQQKRQQQQQQQQQVQHQAQRVGVL---------IPPSLHV--DLTHVQ-----------QGF 186
            : .:...:.|:.|:|..:..:||:..:         :|..|..  |:|::.           .|.
  Rat   265 S-FETLAEYQRWQRQASKVVSQRISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGL 328

  Fly   187 QNFLDFFQLHLFNVT-------------VDFLRDVDLS--GF----------------------- 213
            .....|.||...|::             :..|.:::||  ||
  Rat   329 DTLYKFSQLKGLNLSHNKLGLFPVLLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNVL 393

  Fly   214 ----IKLLELPKYTSV-----------------------------IKTLNAGIMV----ASHVDV 241
                .:|..|.:.||:                             ::.||.|::.    ..|||:
  Rat   394 TALPDELGNLQQLTSLGISFNNFSQIPEVLEKLTMLDKVVMAGNRLEILNLGVLTRMNHVKHVDL 458

  Fly   242 DQN--STIYIGTPSQPRQQHRLHSKQEQEPHRH-HHEDSKAKQFPAGEEESHSSGETEENHWNDA 303
            ..|  .|:.|               :..|.::| .|.|.:..|....:..|..|.|
  Rat   459 RMNHLKTVII---------------ENLEGNKHITHMDLRDNQLTDLDLSSLCSLE--------- 499

  Fly   304 RIFSGHC--HQLAE---------QLALDFNK--TVVLWPCP----RMKISSNFL---PSF--EAI 346
               ..||  :||.|         .|..::||  .|.::|.|    .:::|.|.|   |.:  ||.
  Rat   500 ---QLHCERNQLRELTLSGFSLRNLYANWNKLTAVNVYPVPSLLTSLELSRNLLECIPDWACEAK 561

  Fly   347 SLAVQSISTKLNWSQVDIYIGDDNWGLGLAIAANLHVPYRIEIGRTIRDL---HSQDKPGKAIII 408
            .|.:..||..|                      ...||.||....::|.|   |:......|::.
  Rat   562 KLEILDISYNL----------------------LTEVPMRILSSLSLRKLMVGHNHIHVLPALVE 604

  Fly   409 TAPLNDASTILLLSTIELDWTEQARKDGQGSRPGRQHTKIL---LIDMAASSLDTQHGFYKYLSR 470
            ..|         |..:::.....:|      .|....:|.|   .::.:|:||::      ..|.
  Rat   605 HIP---------LEVLDVQHNTLSR------LPDTLFSKALNLRYLNASANSLES------LPSA 648

  Fly   471 MGGSQS----------DAFARNTGSPAEVVSSNLLVLTLLNDRHRLFLNAAGLMATMQNFRAPLN 525
            ..|.:|          :....:...|..|...:|.||.|.|::.:.| .|:.|....|.....|:
  Rat   649 CAGEESLSVLQLLYLTNNLLTDQCIPVLVGHPHLRVLHLANNQLQTF-PASKLNKLEQLEELNLS 712

  Fly   526 GNYKDPPPSGHRNAS-LHKLYPYRNLLPLY-------------------------DTIVTTTTQS 564
            ||.....|:...|.. ||.|..:.|.:.::                         :|:..|....
  Rat   713 GNKLKAIPTTIANCKRLHTLVAHANNISIFPEILQLPQIQFVDLSCNDLTEILIPETLPATLQDL 777

  Fly   565 D-TSETSPQFDFVVLDIVRDAPVATYKWRPLLILESDPGSRGGGSVVEGGGSYISHSI--HPGYD 626
            | |..|:...:...||:...........:||...:|...|           ::.||.:  ..|..
  Rat   778 DLTGNTNLVLEHKTLDMFSHITTLKIDQKPLPTTDSTVTS-----------TFWSHGLAEMAGQR 831

  Fly   627 EWLLVSSVL-------------------------LWQCGAICWTIAAICVCLLVIMIAGIVAGGI 666
            ..|.||::.                         |.||     |:|.:    |:..:....:..:
  Rat   832 NKLCVSALAMDNFAEGVGAVYGMFDGDRNEELPRLLQC-----TMADV----LLEEVQHSTSDTV 887

  Fly   667 AMRNYFL--RKRLSKGPNKIVLSA-------------SDF------------------------- 691
            .|.|.||  .::|.....|:..||             |.|
  Rat   888 FMANTFLVSHRKLGMAGQKLGSSALLCYIRPDTADPTSSFSLTVANVGTCQAVLCRGGKPVPLSK 952

  Fly   692 VF-----PVDSRRV---------DEGIEAMLCC-----------WL--------------QQLQE 717
            ||     |.:::||         |..:..:.||           |:              .:|..
  Rat   953 VFSLEHDPEEAQRVKDQKAIITEDNKVNGVTCCTRMLGCTYLYPWILPKPHISSTPLTIQDELLI 1017

  Fly   718 FGGPEV-----------------------DKPDLLKGSIGSLKNLGFVI--------------PG 745
            .|...:                       .|...|..|.|...|:|.::              .|
  Rat  1018 LGNKALWEHLSYLEAVSAVRHVQDPLAAAKKLCTLAQSYGCQDNVGAMVVYLNIGEEGCTCEMHG 1082

  Fly   746 AAAPGSAGAIT----------TTANGKSG--------------SSATGSLA--RHNPAHLDMRAR 784
            .|.||..|..:          ||.:..||              ||..||.|  .||...|:....
  Rat  1083 LALPGPVGFASTATIKDAPKPTTPSSSSGIASELSSEVSTSEVSSEVGSTASDEHNTVGLETSLL 1147

  Fly   785 YNGD-LVQLKEVNINGS-------AELRTKAMDLLVMAHGLRHENINPLIGWLSDPNRTAMVFD- 840
            ...: ...|..|...|:       |...:...|     :||..::..|:.|.:::.:|..:..|
  Rat  1148 PRPERRCSLHPVPSAGTFQRQPSCATFSSNQSD-----NGLDSDDDQPVEGVITNGSRVEVEVDI 1207

  Fly   841 YCSRG 845
            :|.||
  Rat  1208 HCCRG 1212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	24/108 (22%)
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485
Phlpp2	NP_001102601.2	RA_PHLPP2	66..178	CDD:340761	29/107 (27%)
		PH_PHLPP-like	185..279	CDD:270131	11/94 (12%)
		PLN00113	284..>762	CDD:215061	98/548 (18%)
		leucine-rich repeat	289..309	CDD:275380	2/19 (11%)
		leucine-rich repeat	310..336	CDD:275380	3/25 (12%)
		leucine-rich repeat	337..359	CDD:275380	2/21 (10%)
		leucine-rich repeat	360..382	CDD:275380	5/21 (24%)
		leucine-rich repeat	383..405	CDD:275380	2/21 (10%)
		leucine-rich repeat	406..428	CDD:275380	2/21 (10%)
		leucine-rich repeat	429..452	CDD:275380	3/22 (14%)
		leucine-rich repeat	453..476	CDD:275380	7/37 (19%)
		leucine-rich repeat	477..497	CDD:275380	4/19 (21%)
		leucine-rich repeat	498..517	CDD:275380	6/30 (20%)
		leucine-rich repeat	518..539	CDD:275380	6/20 (30%)
		leucine-rich repeat	540..562	CDD:275380	6/21 (29%)
		leucine-rich repeat	563..584	CDD:275380	8/42 (19%)
		leucine-rich repeat	586..607	CDD:275380	4/20 (20%)
		leucine-rich repeat	608..631	CDD:275380	4/28 (14%)
		leucine-rich repeat	632..681	CDD:275380	8/54 (15%)
		leucine-rich repeat	682..705	CDD:275380	8/23 (35%)
		leucine-rich repeat	706..728	CDD:275380	5/21 (24%)
		leucine-rich repeat	751..772	CDD:275380	1/20 (5%)
		PP2Cc	820..1069	CDD:238083	39/257 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900