DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34357 and NPR3

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	NP_001191304.1	Gene:	NPR3 / 4883	HGNCID:	7945	Length:	541	Species:	Homo sapiens

Alignment Length:	754	Identity:	145/754 - (19%)
Similarity:	224/754 - (29%)	Gaps:	315/754 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   594 LLILESDP----------GSRGGGSVVEGGGS-------YISHSIHPGYDEWLLVSSVLLWQCGA 641
            ||:|...|          |..|||.|..|||.       ....::.|...|.|    |||.|..:
Human     4 LLVLTFSPCVLLGWALLAGGTGGGGVGGGGGGAGIGGGRQEREALPPQKIEVL----VLLPQDDS 64

  Fly   642 ICWTIAAICVCLLVIMIAGIVAGGIAMRNYFLRKRLSKGPNKIVLSASDFVFPVDSRRVDEGIEA 706
            ..:::..:...:                .|.||.....|..:.:|.... .|.|.....|.|..|
Human    65 YLFSLTRVRPAI----------------EYALRSVEGNGTGRRLLPPGT-RFQVAYEDSDCGNRA 112

  Fly   707 MLCCWLQQLQEFGGPEVDKPDLLKGSIGSLKNLGFVIPGAAAPG------------SAGAITTTA 759
            :    ...:.........||||:         ||.|...||||.            ||||:  .|
Human   113 L----FSLVDRVAAARGAKPDLI---------LGPVCEYAAAPVARLASHWDLPMLSAGAL--AA 162

  Fly   760 NGKSGSSATGSLARHNPAHLDMRARYNGDLVQLKEVNINGSAELRTKAMDLLVMAHGLRHENINP 824
            ..:...|....|.|..||:..|     |::                    :|.:   .||.:
Human   163 GFQHKDSEYSHLTRVAPAYAKM-----GEM--------------------MLAL---FRHHH--- 196

  Fly   825 LIGWLSDPNRTAMVFDYCSRGSLQDVLIMDEIKLDWSFRLSLLTDLVRGMRYLHTSPLRVHGALT 889
               |    :|.|:|:.            .|:::.:..|.|..:.::.: ...||||
Human   197 ---W----SRAALVYS------------DDKLERNCYFTLEGVHEVFQ-EEGLHTS--------- 232

  Fly   890 SRNCVVDARWVLKITDYGLNSFYESQGLP----PRTRSAKE---LLWTAPELLRNMKLHQHHHQH 947
                              :.||.|::.|.    .|...|.|   ::..:.:.:|::.|..|.|
Human   233 ------------------IYSFDETKDLDLEDIVRNIQASERVVIMCASSDTIRSIMLVAHRH-- 277

  Fly   948 GRIQLGTQLGDVYSFGIIMQEVV----------VRGEPYCMLSLSPEEIIVKIKKPPPLIRPSVS 1002
                 |...||...|.|   |:.          .||:.:..                     ...
Human   278 -----GMTSGDYAFFNI---ELFNSSSYGDGSWKRGDKHDF---------------------EAK 313

  Fly  1003 KGAAPPEAINIMRQCWAEQPDMRPDFNSVYERFKM----------LNHGRKVN-FVDTMFQMLEK 1056
            :..:..:.:.::|       .::|:|    |:|.|          ||....|| ||:.....:..
Human   314 QAYSSLQTVTLLR-------TVKPEF----EKFSMEVKSSVEKQGLNMEDYVNMFVEGFHDAILL 367

  Fly  1057 YSNNLEELIRERTEQLDIERKKTEQLLNRMLPSSVAEKLKMGLAVDPEEFSDVTIYFSDIVGFTT 1121
            |...|.|::|....:.| ..|..:|..||.                          |..|.|..:
Human   368 YVLALHEVLRAGYSKKD-GGKIIQQTWNRT--------------------------FEGIAGQVS 405

  Fly  1122 IAAHCSPVQVVDLLNDLYTIFDATINAYNVYKVETIGDAYMVVSGLPVKIPDHAEQIATMALDLL 1186
            |                    ||..:.|..:.|..:.|   |.:|....|.|:           .
Human   406 I--------------------DANGDRYGDFSVIAMTD---VEAGTQEVIGDY-----------F 436

  Fly  1187 HQSGRF----NVKHLPGVPLQLRIG-------LHTGPC----------CAGVV-------GLTMP 1223
            .:.|||    |||: |..||:|||.       .::.||          ..|:|       ||.|.
Human   437 GKEGRFEMRPNVKY-PWGPLKLRIDENRIVEHTNSSPCKSSGGLEESAVTGIVVGALLGAGLLMA 500

  Fly  1224 RYCL---FGDTVNTASRMESTG---------SSWRIHMS 1250
            .|..   :..|:...::.|.:.         .|.|.|.|
Human   501 FYFFRKKYRITIERRTQQEESNLGKHRELREDSIRSHFS 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	48/304 (16%)
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	43/217 (20%)
NPR3	NP_001191304.1	PBP1_NPR_C_like	54..446	CDD:107381	109/608 (18%)
		ANF_receptor	71..422	CDD:279440	95/549 (17%)
		TM_EphA1	476..507	CDD:214014	6/30 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810