Protein Alignment CG34357 and NPR2

DIOPT Version :9

• Sequence 1: NP_001356914.1
• Gene: CG34357 / 5740349
• FlyBaseID: FBgn0085386
• Length: 1689
• Species: Drosophila melanogaster
• Sequence 2: XP_024303324.1
• Gene: NPR2 / 4882
• HGNCID: 7944
• Length: 1103
• Species: Homo sapiens
• Alignment Length: 1161
• Identity: 375/1161 - (32%)
• Similarity: 507/1161 - (43%)
• Gaps: 290/1161 - (24%)

  Fly   328 WPCPRMKISSNFLPSFEAISLAVQS-----------ISTKLN---------WSQVDIYIGDD--- 369
            |..||:.         .|::|||::           :|::|.         .|.||:.:..|
Human    40 WAWPRVG---------PAVALAVEALGRALPVDLRFVSSELEGACSEYLAPLSAVDLKLYHDPDL 95

  Fly   370 ------------------NWGLGL----AIAA-----NLHVPYRIEIGRTIRDLHSQDKPGKAII 407
                              :|.|.|    |:|:     |.|  ||    ..:|...|..|.|:.::
Human    96 LLGPGCVYPAASVARFASHWRLPLLTAGAVASGFSAKNDH--YR----TLVRTGPSAPKLGEFVV 154

  Fly   408 ITAPLNDASTILLLSTI--ELDWTEQ-------ARKDGQGSRPGRQHTKILLIDMAASSLDTQHG 463
                           |:  ..:||.:       ||.|   .||.....:.:...:..|:|..||
Human   155 ---------------TLHGHFNWTARAALLYLDARTD---DRPHYFTIEGVFEALQGSNLSVQH- 200

  Fly   464 FYKYLSRMGG-SQSDAFARNTG------SPAEVVSSNLLVL---TLLNDRHRLF--------LNA 510
             ..|....|| .|:..|.|..|      .|.|::...||..   .|.|..:..|        |.|
Human   201 -QVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRA 264

  Fly   511 AGLMAT----------------MQNFRAPLNGNYKDPPPSGHRNASLHKLYPYR----------- 548
            ....||                .:.|:..|...|::||...::......|...|
Human   265 GPTRATGRPWQDNRTREQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELGPSL 329

  Fly   549 -NLLP--LYDTIV-------TTTTQSDTSETSPQFDFVVLDIVRDAPVATYKWRPLLILESDPGS 603
             ||:.  .||.|:       .|..:..|.|..       |.||.......|.....|::......
Human   330 MNLIAGCFYDGILLYAEVLNETIQEGGTREDG-------LRIVEKMQGRRYHGVTGLVVMDKNND 387

  Fly   604 RGGGSVVEGGGSYISHSIHPGYDEWLLVSSVLLWQCGAICWTIAA------ICVCLL-------- 654
            |....|:...|...|....|. ..:......:.|....|.|...|      .|...|
Human   388 RETDFVLWAMGDLDSGDFQPA-AHYSGAEKQIWWTGRPIPWVKGAPPSDNPPCAFDLDDPSCDKT 451

  Fly   655 VIMIAGIVAGGIAMRNYFLRKRLSKGPNKIVLSASDFVF--PVDSRRVDEGIEAMLCCWLQQLQE 717
            .:....|||             |..|...|:...|.|:.  |.....:::.:.:||  |..:.:|
Human   452 PLSTLAIVA-------------LGTGITFIMFGVSSFLIFRPYRKLMLEKELASML--WRIRWEE 501

  Fly   718 --FGGPEVDKPDLLKGSIGSLKNLGFVIPGAAAPGSAGAITTTANGKSGSSATGSLARHNPAHLD 780
              ||..|    ...||: ||...|       :..||:.....||:||....|       |..|
Human   502 LQFGNSE----RYHKGA-GSRLTL-------SLRGSSYGSLMTAHGKYQIFA-------NTGH-- 545

  Fly   781 MRARYNGDLVQLKEVNINGSAELRTKAMDLLVMAHGLRHENINPLIGWLSDPNRTAMVFDYCSRG 845
                :.|::|.:|.|| ....||..:.:..|.....::..::...||...||....:|.:||.||
Human   546 ----FKGNVVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRG 605

  Fly   846 SLQDVLIMDEIKLDWSFRLSLLTDLVRGMRYLHTSPLRVHGALTSRNCVVDARWVLKITDYGLNS 910
            ||||:|..|.|.|||.||.||:.|||:||.:||.|.:..||:|.|.|||||:|:|||||||||.|
Human   606 SLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLAS 670

  Fly   911 F------------YESQG-----------LPPRTRSA---------------------------- 924
            |            |.|:.           .|||....
Human   671 FRSTAEPDDSHALYASEAHPHNPLFILLLFPPRDGGRGRWSDSNIGMSPGGLGGAPFRGTWPAGF 735

  Fly   925 --KELLWTAPELLRNMKLHQHHHQHGRIQLGTQLGDVYSFGIIMQEVVVRGEPYCM--LSLSPEE 985
              .|.||||||||....|.         ..|.|..||||||||:||:.:|..|:.:  |.|||:|
Human   736 LFSEKLWTAPELLSGNPLP---------TTGMQKADVYSFGIILQEIALRSGPFYLEGLDLSPKE 791

  Fly   986 IIVKIKK-PPPLIRPSVSKGAAPPEAINIMRQCWAEQPDMRPDFNSVYERFKMLNHGRKVNFVDT 1049
            |:.|::. ..|..|||:.:.....|.:.:|.:|||:.|..||||..:....:..|.....:.:|.
Human   792 IVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPAERPDFGQIKGFIRRFNKEGGTSILDN 856

  Fly  1050 MFQMLEKYSNNLEELIRERTEQLDIERKKTEQLLNRMLPSSVAEKLKMGLAVDPEEFSDVTIYFS 1114
            :...:|:|:||||:|:.|||:....|::|.|.||.::||.||||:||.|..|..|.|..||||||
Human   857 LLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFS 921

  Fly  1115 DIVGFTTIAAHCSPVQVVDLLNDLYTIFDATINAYNVYKVETIGDAYMVVSGLPVKIPD-HAEQI 1178
            ||||||.::|..:|:|||.|||||||.|||.|:.::||||||||||||||||||.:... ||.:|
Human   922 DIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEI 986

  Fly  1179 ATMALDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGS 1243
            |.|||.||.....|.::|.|...|:||||:||||.|||||||.|||||||||||||||||||.|.
Human   987 ARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQ 1051

  Fly  1244 SWRIHMSQETRDRLDARGGYAIEPRGLIDIKGKGMMNTFWLLG-KKGFDKPLPAPP 1298
            :.:||:|..|:|.||..|.:.:|.||.:::||||.|.|:|||| :||       ||
Human  1052 ALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGERKG-------PP 1100

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	114/333 (34%)
		CYCc	1074..1266	CDD:214485	119/192 (62%)
NPR2	XP_024303324.1	Periplasmic_Binding_Protein_Type_1	26..421	CDD:324556	81/423 (19%)
		PK_GC-A_B	521..848	CDD:270944	120/349 (34%)
		HNOBA	<857..902	CDD:311573	21/44 (48%)
		CYCc	881..1065	CDD:214485	116/183 (63%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820