Protein Alignment CG34357 and NPR1

DIOPT Version :10

• Sequence 1: NP_001356914.1
• Gene: CG34357 / 5740349
• FlyBaseID: FBgn0085386
• Length: 1689
• Species: Drosophila melanogaster
• Sequence 2: NP_000897.3
• Gene: NPR1 / 4881
• HGNCID: 7943
• Length: 1061
• Species: Homo sapiens
• Alignment Length: 1045
• Identity: 338/1045 - (32%)
• Similarity: 480/1045 - (45%)
• Gaps: 244/1045 - (23%)

  Fly   341 PSFEAISLAVQSISTKLNWSQVDIYI-----GDDNW------GLGLAIAANLHVPY------RIE 388
            ||:..:...|.::..:|.|.:..:.:     ||:..      ||.:.:...|::..      ..:
Human   160 PSYAKLGDFVAALHRRLGWERQALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDD 224

  Fly   389 IGRTIRDLHSQDKPGKAIIITAPLNDASTILLLST-----------IELDWTEQARKDGQGSRPG 442
            :....|.|.:..:.|:.|.|.:..:...|::||:.           ..||...|:.:.|||..|.
Human   225 LSHYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPR 289

  Fly   443 RQHTKILLIDMAASSLDTQHGFYKYLSRMGGSQSDAFARNTGSPAEVVSSNLLVLTLLNDRHRLF 507
            |...:                         |...|..||.....|::::
Human   290 RPWER-------------------------GDGQDVSARQAFQAAKIIT---------------- 313

  Fly   508 LNAAGLMATMQNFRAPLNGNYKDPPPSGHRNASLHKLYPYRNLLPLYDTIVTTTTQSDTSETSPQ 572
                                ||||....:    |..|...::|  .|:                |
Human   314 --------------------YKDPDNPEY----LEFLKQLKHL--AYE----------------Q 336

  Fly   573 FDFVVLD-IVRDAPVATYKWRPLLILESDPGSRGGGSVVEGGG--SYISHSIHPGYDEWLLVSS- 633
            |:|.:.| :|...|.:.:....|.|.........||:|.:|..  ..:.:....|...:|.:.|
Human   337 FNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSS 401

  Fly   634 ------VLLWQCGAICWTIAAICVCLLVIMIAGIVAGGIAMRNYFLRKRLSKGPNKIVLS---AS 689
                  ..||....                                    ..|..::||:   .|
Human   402 GDRETDFSLWDMDP------------------------------------ENGAFRVVLNYNGTS 430

  Fly   690 DFVFPVDSRRVDEGIEAMLCCWLQQLQEFGGPEVDKP-------------DLLK-----GSIGSL 736
            ..:..|..|:::         |     ..|.|..|.|             |.|.     ..:|||
Human   431 QELVAVSGRKLN---------W-----PLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGSL 481

  Fly   737 KNLGFVI----------------------------PGAAAP--GSAGAITTTANGKSGSSATGSL 771
            ..||.:|                            |.:...  .|||: ..|.:|: ||:....|
Human   482 SLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGS-RLTLSGR-GSNYGSLL 544

  Fly   772 ARHNPAHLDMR-ARYNGDLVQLKEVNINGSAELRTKAMDLLVMAHGLRHENINPLIGWLSDPNRT 835
            .......:..: |.|.|:||.:|.|| ....||..|.:..|.....:::|::...:|..:||...
Human   545 TTEGQFQVFAKTAYYKGNLVAVKRVN-RKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNI 608

  Fly   836 AMVFDYCSRGSLQDVLIMDEIKLDWSFRLSLLTDLVRGMRYLHTSPLRVHGALTSRNCVVDARWV 900
            .::.:||.||||||:|..:.|.|||.||.||..|:|:||.:||...:..||.|.|.|||||.|:|
Human   609 CILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFV 673

  Fly   901 LKITDYGLNSFYESQGLPPRTRSAKELLWTAPELLRNMKLHQHHHQHGRIQLGTQLGDVYSFGII 965
            ||||||||.||.:.......|..||: |||||||||.......         |:|.|||||||||
Human   674 LKITDYGLESFRDLDPEQGHTVYAKK-LWTAPELLRMASPPVR---------GSQAGDVYSFGII 728

  Fly   966 MQEVVVRGEPYCM--LSLSPEEIIVKI---KKPPPLIRPSVSKGAAPPEAINIMRQCWAEQPDMR 1025
            :||:.:|...:.:  |.|||:|||.::   ::||  .|||::..:...|...:|::||||.|..|
Human   729 LQEIALRSGVFHVEGLDLSPKEIIERVTRGEQPP--FRPSLALQSHLEELGLLMQRCWAEDPQER 791

  Fly  1026 PDFNSVYERFKMLNHGRKVNFVDTMFQMLEKYSNNLEELIRERTEQLDIERKKTEQLLNRMLPSS 1090
            |.|..:....:..|.....|.:|.:...:|:|:||||||:.|||:....|::|.|.||.::||.|
Human   792 PPFQQIRLTLRKFNRENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHS 856

  Fly  1091 VAEKLKMGLAVDPEEFSDVTIYFSDIVGFTTIAAHCSPVQVVDLLNDLYTIFDATINAYNVYKVE 1155
            |||:||.|..|..|.|..||||||||||||.::|..:|:|||.|||||||.|||.|:.::|||||
Human   857 VAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVE 921

  Fly  1156 TIGDAYMVVSGLPVKIPD-HAEQIATMALDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVG 1219
            ||||||||||||||:... ||.::|.|||.||.....|.::|.|...|:||||:||||.||||||
Human   922 TIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVG 986

  Fly  1220 LTMPRYCLFGDTVNTASRMESTGSSWRIHMSQETRDRLDARGGYAIEPRGLIDIKGKGMMNTFWL 1284
            |.|||||||||||||||||||.|.:.:||:|.||:..|:..||:.:|.||.:::||||.:.|:||
Human   987 LKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWL 1051

  Fly  1285 LGKKG 1289
            ||::|
Human  1052 LGERG 1056

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	Protein Kinases, catalytic domain	763..1041	CDD:473864	112/283 (40%)
		HNOBA	<1047..1095	CDD:462234	23/47 (49%)
		CYCc	1074..1266	CDD:214485	119/192 (62%)
NPR1	NP_000897.3	PBP1_NPR_A	36..443	CDD:380608	62/410 (15%)
		PK_GC-A_B	534..807	CDD:270944	113/286 (40%)
		HNOBA	<813..861	CDD:462234	23/47 (49%)
		CYCc	840..1032	CDD:214485	119/191 (62%)