DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34357 and CG31183

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster

Alignment Length:	1665	Identity:	460/1665 - (27%)
Similarity:	676/1665 - (40%)	Gaps:	479/1665 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 PQQKRQQQQQQQQQVQHQAQRVGVLIPPSLHVDLTHVQQGFQNFLDFFQLHLFNVTVDFLRDVDL 210
            |:.|...:.|..:.|||.         |||.:. .|.:.|.:..|.|..| |.:|..|...|..:
  Fly    52 PETKNSHKSQSTELVQHF---------PSLPMP-DHRRLGARRQLVFVAL-LPSVESDNKNDCIM 105

  Fly   211 SGFIKLLELPKYTSVIKTLNAGIMVASHVDVDQNSTIYIGTPSQPRQQHRLHSKQEQEPHRHHHE 275
            ...:.:|||    ::......|.:..||.|:...|                             .
  Fly   106 PKVLPVLEL----AIRHVQRMGFVGGSHFDIQLIS-----------------------------R 137

  Fly   276 DS--KAKQFPAGEEESHSSGETEENHWNDAR-IFSGHCHQLAEQLALDFNKTVVLWPCPRMKISS 337
            |:  .:|..|.|..|.::       .|.:.. :|...|    |.:....::...:|..|.:....
  Fly   138 DTFCSSKYGPIGFFEIYT-------QWPEVNAVFGLPC----EYVLAPISRYADVWQVPVLTTGG 191

  Fly   338 N---FLPSFEAISL--------------AVQSISTKLNWSQVDIYIGDDNWGLG------LAIAA 379
            |   |....|:.|.              .|::|....||::..:...::|..:.      |.:||
  Fly   192 NAKEFNKKSESYSTLTRLKGAQVNNLGNVVRAILNSFNWTRTALIYQNENAKVKGNSVCFLCLAA 256

  Fly   380 -----NLHVPYRI----------EIGRTIRDLHSQDK-------PG--KAIIITA-PLN--DAST 417
                 ..|..|::          :|.|.::::..|.:       |.  :.|::|| .||  |:..
  Fly   257 IHDTIEEHSVYQLGFDTSTWTKADITRMLKNVAMQSRIVIMCADPQSIRQIMLTAEELNMIDSGE 321

  Fly   418 ILLLSTIEL----------DWTEQARKDGQGSRPGRQHTKILLIDMAASSLDTQHGFYKYLSRMG 472
            .:.:: |||          .|.::...|....|..:.:|.:|.:.....: |.::      :|:
  Fly   322 YVFIN-IELFSRVQYLTSQPWYDKNDTDLNNERAQKAYTAMLTVTPKQPN-DNEY------TRV- 377

  Fly   473 GSQSDAFARN----TGSPAEVVSSNLLVLTLLNDRHRLFLNAAGLMATMQNFRAPLNGNYKDPPP 533
            .::..|.|..    |.|..|.:|:   .:|...|...|:.||             ||.:.::.|.
  Fly   378 SNEIKAIAAEKYNYTFSDNEPISA---FVTSFFDGVLLYANA-------------LNESIREDPT 426

  Fly   534 SGHRNASLHKLYPYRNLLPL--YDTIVTTTTQSDTSETSPQFDFVVLDIVRDAPVATYKWRPLLI 596
            ...|              |:  .|.:.....:|.|..|..    |.:|...|. ::.|.     :
  Fly   427 MLTR--------------PINGTDMVRRMWNRSFTGITGN----VTIDANGDR-LSAYS-----L 467

  Fly   597 LESDPGSRGGGSVVEGGGSYISHSIHP--------------------------GYDEWLLVSSVL 635
            |:.:|        ..|....::|.:|.                          |||
  Fly   468 LDMNP--------TTGRFEIVAHFLHNRLEFEANKEIHWAGDREEAPPDRPICGYD--------- 515

  Fly   636 LWQCGAIC-------WTIAAICVCLLVIMIAGIVAGGIAMRNYFLRKRLSKGPNKIVLSASDFVF 693
                ||:|       :.|.:|.:..:|:::|  |......|:|.....::....|:  |..|.:|
  Fly   516 ----GALCPDNSLPGYAILSIVLGTMVVVMA--VCFFFGYRHYIAEAEINSMSWKV--SLEDVMF 572

  Fly   694 PVDSRRVDEGIEAMLCCWLQQLQEFGGPEVDKPDLLKGSIGSLKNLGFVIPGAAAPGSAGAITTT 758
                               :...|.|         |:||..||......:              |
  Fly   573 -------------------RDAAERG---------LRGSFHSLVKQSSQL--------------T 595

  Fly   759 ANGKSGSSATGSLARHNPAHLDMRARYNGDLVQLKEVNINGSAELRTKAMDL-LVMAHGLRHENI 822
            ...:...|..|......|..:..:::     |.:|.|.::....|.|:::.| |.....|:|:::
  Fly   596 LMSEDMVSINGDRQIFIPVGMFRKSK-----VAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHL 655

  Fly   823 NPLIGWLSDPNRTAMVFDYCSRGSLQDVLIMDEIKLDWSFRLSLLTDLVRGMRYLHTSPLRVHGA 887
            ....|...|..|:.::.:||.:|||||:|..::.:|||.|||||:.|:||||::||:|.:|.||.
  Fly   656 VKFYGACLDQRRSFLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGN 720

  Fly   888 LTSRNCVVDARWVLKITDYGLNSF------YESQGLPPRTRSA-KELLWTAPELLRNMKLHQHHH 945
            |.|.|||||:|:||||||:||::.      .||.|....:.:. .:||||||||||        .
  Fly   721 LKSSNCVVDSRFVLKITDFGLHTLRRTRFDLESDGGNCNSHAYWSKLLWTAPELLR--------V 777

  Fly   946 QHGRIQLGTQLGDVYSFGIIMQEVVVRGEPY----CMLSLSPEEIIVKIK--------KPPPLIR 998
            :|.|...|||.||||:||||:.|:..|..|:    |....||:|||..:|        ||   .|
  Fly   778 EHNRPPEGTQKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKP---FR 839

  Fly   999 PSVSKGAAPPEAIN-IMRQCWAEQPDMRPDFNSVYERFKMLNHGRKV-NFVDTMFQMLEKYSNNL 1061
            |.:.........|| |:|:||||.|..|||||::....:..|...:. |.||.:.:.:|.|:|||
  Fly   840 PELEPNGDTKADINGIIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNL 904

  Fly  1062 EELIRERTEQLDIERKKTEQLLNRMLPSSVAEKLKMGLAVDPEEFSDVTIYFSDIVGFTTIAAHC 1126
            |||:.|||:....|:||.|:||.::||.|||.:|..|..|..|.|..||||||||||||.|:|..
  Fly   905 EELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAES 969

  Fly  1127 SPVQVVDLLNDLYTIFDATINAYNVYKVETIGDAYMVVSGLPVKIPD-HAEQIATMALDLLHQSG 1190
            :|:|||..||||||.||:.:..::||||||||||||||||||::..: ||.:||.:||.||....
  Fly   970 TPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVH 1034

  Fly  1191 RFNVKHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGSSWRIHMSQETRD 1255
            .|.:.|.|...|:||||||||.|.||||||.|||||||||||||||||||.|.:.:||:|:.|::
  Fly  1035 NFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKE 1099

  Fly  1256 RLDARGGYAIEPRGLIDIKGKGMMNTFWLLGKKGFDKPLPAPPPIGESHGLDESLIRNSITLKAQ 1320
            .||..|.:....||.:.:||||.|.|:||.|:      :|.|          .|||..|   |..
  Fly  1100 ALDEFGTFVTTRRGFVPMKGKGEMLTYWLEGE------VPRP----------NSLISPS---KLM 1145

  Fly  1321 ANKSRTSTNPSSSQSSSLAGESVEVKVEITPPTNADLASGTNLPNSYSLDSNSTNTISPNATLCP 1385
            ..:..:...|..|||.:|..:..|:.|...||         .||              |.|...|
  Fly  1146 LTRRSSLKQPQRSQSHNLHKQYSELVVASPPP---------QLP--------------PPAIALP 1187

  Fly  1386 EFPGKTTPSSTSPQ---SRKLSELTPENLLNPNSFNRLPSSTGGSSSRLYKKIEEMMDLSSPYNH 1447
            ..|   :||..||.   .||:|..:|:  ||...|:             |.|.|         ||
  Fly  1188 PPP---SPSKDSPNLRVKRKISSSSPK--LNGGGFD-------------YHKTE---------NH 1225

  Fly  1448 YKCLSPSESNLTQFYDGKYLYGSVAGGAGGGQAGGGACASIALSGSGCGGGASRFDSKPGSSRLL 1512
            |...:.:.......|                                             |||.|
  Fly  1226 YLDTAAAAQRNCDIY---------------------------------------------SSRSL 1245

  Fly  1513 RRQFSLDRDDQQAKGEQQHHQHSLQANTYSGLVGGCGGGVKSSMLDIPLLHDTTRSPKGTLTRSH 1577
            |     |.::.....|..|.:..|            .|.:||.       |....:..|.:..:.
  Fly  1246 R-----DMEETSDSWELAHFRLPL------------SGALKSH-------HHLNNNSHGYVHSNS 1286

  Fly  1578 KQNSASITQ----DLEKIEEIPLSPASSQHHSSLDSNLNRSP-PST------------LEAQSPP 1625
            ..|.:.|.|    .:::....| ||..|...:|..|..|.|| |.|            .|....|
  Fly  1287 SSNLSGILQPPPLGVQRTRLKP-SPTISTLLTSARSEANASPGPETGSMGSGQLRIKFAEGDETP 1350

  Fly  1626 LPPMSPPQLSAPTSP-----APSRTLNGIYAHNSNSTSSH 1660
            |.|..||..:.|..|     :|.|:.:|   .|..:.|||
  Fly  1351 LLPTPPPLAAPPPIPQMVAASPQRSGSG---QNIPADSSH 1387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	113/298 (38%)
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	114/192 (59%)
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	88/511 (17%)
		ANF_receptor	108..473	CDD:279440	79/465 (17%)
		PK_GC-A_B	589..883	CDD:270944	114/323 (35%)
		Pkinase_Tyr	613..877	CDD:285015	110/279 (39%)
		HNOBA	<893..938	CDD:285003	22/44 (50%)
		CYCc	917..1108	CDD:214485	114/190 (60%)
		Guanylate_cyc	944..1130	CDD:278633	111/185 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920