DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34357 and CG3216

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster

Alignment Length:	1237	Identity:	360/1237 - (29%)
Similarity:	545/1237 - (44%)	Gaps:	317/1237 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 KLLELPKYT------SVIKTLNAGIMVASHVD---------------VDQNSTIYIGTPSQPRQQ 258
            |..:|.:||      |.::..|.|:::|||:|               :|:.:.:::
  Fly    69 KSTQLSRYTEVGEMGSTMRVYNVGVLMASHLDSPFDLERCGPAVDLALDEINKVFL--------- 124

  Fly   259 HRLHSKQEQEPHRHHHEDSKAKQFPAGEEESHSSGETEENHWNDARI-FSGHCHQLA----EQLA 318
                     :||.......|. .:|:. ..:.:.|...:.::.|..| |.|.....|    .:||
  Fly   125 ---------KPHNITLLKKKG-SYPSC-SGARAPGLAADMYFQDDVIAFIGPACAFALEPVARLA 178

  Fly   319 LDFNKTVV--LWPCP-----RMKISSNFL--------------------PSFEAIS-------LA 349
            ..:||.::  :...|     .:.::|..|                    |:...:|       |.
  Fly   179 AYWNKPIITGMGDQPPSSEGELTVTSGILGRIHKWKNENTGMFKDKSKYPTLTRMSYCQCRLILV 243

  Fly   350 VQSISTKLNWSQVDIYIGDD---NWGLGLAIAANLHVPYRIE-IGRTIRDLHSQDKPGKAIIITA 410
            ..|:..:.||:.|.:.:...   :|.:|    .||....|.| :...:::|:..::.    :...
  Fly   244 FASVIRQFNWNHVALLVDRSELFSWTVG----KNLEYGLRQEGLLSFVKELNGNEEE----VYEN 300

  Fly   411 PLNDAS---TILLLSTIELDWTEQARKDGQGSRPGRQHTKILLIDMAASSLDTQHGFYKYL---- 468
            .|.|||   .:::||.                 .|....|.:|   ||.||...:|.:.:|
  Fly   301 YLKDASMYARVVILSV-----------------RGVLVRKFML---AAHSLGMTNGEWVFLDVEI 345

  Fly   469 --SRMGGSQSDAFARNTGSPAEVVSSNLLVLTLLNDRHRLFLNAAGLMATMQNFRAPLNGNYKDP 531
              |...|.:.........:.|......||.::||.                     |.:..::|.
  Fly   346 FQSEYWGDKGWEMKDEHDAKARKAYEALLRVSLLQ---------------------PTSPKFQDF 389

  Fly   532 PPSGHRNASLHKLYPYRNLL-----------PLYDTIV--------TTTTQSDTSE----TSPQF 573
            ..:...||    ||.|....           ..||.:.        |.|...|..:    |...:
  Fly   390 ADNVRENA----LYDYNYTFGEGEEVNFFIGAFYDGVYLLGMALNETLTEGGDIRDGVNITRRMW 450

  Fly   574 DFVVLDIV----------RDAPVATYKWRPLLILESDPGSRGGGSVVEGGGSYISH--SIHPGYD 626
            :.....|.          |||..:        ||:.||        :.|..|.::|  .:|..|
  Fly   451 NRTFEGITGHVRIDDNGDRDADYS--------ILDLDP--------INGKFSVVAHYSGVHKVY- 498

  Fly   627 EWLLVSSV----LLW------------QCG-------------AICWTIAAICVCLLVIMIAGIV 662
                 |:|    :.|            .||             .|.:::..:      ::..|:|
  Fly   499 -----SAVHGKKIHWPGGREEPPPDVPPCGFLGNSTDCVGNFSTIMYSVFGL------LLFLGLV 552

  Fly   663 AGGIAMRNYFLRK--RLSKGPNKIVLSASDFVFPVDSRRVDEGIEAMLCCWLQQLQEFGGPEVDK 725
            ...|.:    |:|  :|||..|.:    |..|.|.|                 .|.|.||
  Fly   553 FLVICL----LQKQMKLSKELNNM----SWRVRPDD-----------------VLIEMGG----- 587

  Fly   726 PDLLKGSIGSLKNLGFVIPGAAAPGSAGAITTTANG-KSGSSATGSLARHNPAHLDMRARYNGDL 789
               :.||.|.|:.|           ....|:....| .||.::..|.....|.......::.|:.
  Fly   588 ---MFGSKGGLQRL-----------DVENISLQQFGIHSGRASIASFTSLPPQVYTTIGQFKGER 638

  Fly   790 VQLKEVNINGSAELRTKAMDLLVMAHGLRHENINPLIGWLSD-PNRTAMVF-DYCSRGSLQDVLI 852
            |.:|:||:. ..:|..:.:..:..|..:.|||....:|...| |..|.::. :|||||||:|||.
  Fly   639 VAIKKVNVK-KVDLTPQLLWEIKQARDVSHENTVRFVGACIDLPRPTVLILTEYCSRGSLKDVLE 702

  Fly   853 MDEIKLDWSFRLSLLTDLVRGMRYLHTSPLRVHGALTSRNCVVDARWVLKITDYGLNSFYESQGL 917
            .:.|:|||:||:||:.|:|:||.|||.|.:..||.|.|.||::|.|:||||:|:||.:.......
  Fly   703 NEAIELDWNFRMSLIHDIVKGMNYLHNSDVAAHGKLRSCNCLIDGRFVLKISDFGLRTLTTPSDF 767

  Fly   918 PPRTRSAKELLWTAPELLRNMKLHQHHHQHGRIQL--------GTQLGDVYSFGIIMQEVVVRGE 974
            ........:|||.|||||               .|        .||.|||||||||::|:|.||.
  Fly   768 VRDQNYYLKLLWIAPELL---------------PLTTIPGCCPATQRGDVYSFGIILEEIVNRGG 817

  Fly   975 PY--CMLSLSPEEIIVKIKKPPPLIRPSVSKGAAPPEAINIMRQCWAEQPDMRPDFNSVYERFKM 1037
            ||  ....:....|:.|:::... .||.:.:...||:.:.:|.:|||:..:.||.|:::....:.
  Fly   818 PYQEARQQMDVHTILHKVRQCNG-FRPLIRERECPPDLLELMEKCWADNQEERPTFSTIRSNIRT 881

  Fly  1038 LNHGRKVNFVDTMFQMLEKYSNNLEELIRERTEQLDIERKKTEQLLNRMLPSSVAEKLKMGLAVD 1102
            :..|...|.:|.:...:|:|:||||.|:.|:|.||.:|:::||:||.::||..||::|..|..|:
  Fly   882 IMKGFCENLMDDLLNRMEQYANNLESLVEEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVE 946

  Fly  1103 PEEFSDVTIYFSDIVGFTTIAAHCSPVQVVDLLNDLYTIFDATINAYNVYKVETIGDAYMVVSGL 1167
            |||||.||||||||||||.:.|..||:.||:.|||||:.||..|..|:|||||||||||:|||||
  Fly   947 PEEFSSVTIYFSDIVGFTELCARSSPMDVVNFLNDLYSTFDRIIGFYDVYKVETIGDAYLVVSGL 1011

  Fly  1168 PVKIPD-HAEQIATMALDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDT 1231
            |....| ||.:||.||||:|.....||::|.|...:|:|||:|:|..||||||..||.|||||||
  Fly  1012 PEPNGDKHAREIALMALDILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDT 1076

  Fly  1232 VNTASRMESTGSSWRIHMSQETRDRLDARGGYAIEPRGLIDIKGKGMMNTFWLLG-KKGFDKPLP 1295
            |||||||||||...:||:|..|:..||..|.:.:|.||.:::||||.:.|:||.. .:|..:| |
  Fly  1077 VNTASRMESTGQPGKIHVSSATKAILDKFGTFQMEQRGDVELKGKGTVTTYWLNSTSEGEARP-P 1140

  Fly  1296 AP 1297
            .|
  Fly  1141 TP 1142

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	98/289 (34%)
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	113/192 (59%)
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	84/494 (17%)
		ANF_receptor	107..479	CDD:279440	73/452 (16%)
		PKc_like	616..885	CDD:304357	96/285 (34%)
		TyrKc	627..877	CDD:197581	94/266 (35%)
		HNOBA	<882..939	CDD:285003	23/56 (41%)
		CYCc	918..1109	CDD:214485	113/190 (59%)
		Guanylate_cyc	945..1131	CDD:278633	112/185 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920