Protein Alignment CG34357 and GUCY2D

DIOPT Version :10

• Sequence 1: NP_001356914.1
• Gene: CG34357 / 5740349
• FlyBaseID: FBgn0085386
• Length: 1689
• Species: Drosophila melanogaster
• Sequence 2: NP_000171.1
• Gene: GUCY2D / 3000
• HGNCID: 4689
• Length: 1103
• Species: Homo sapiens
• Alignment Length: 1087
• Identity: 384/1087 - (35%)
• Similarity: 537/1087 - (49%)
• Gaps: 235/1087 - (21%)

  Fly   314 AEQLALDFNKTVVLWPCPRMKISSNFLPSFEAISLAVQSISTKLNWSQVDIYIG-DDNWGLGLAI 377
            ||.||.:....:|.|.||..:......|:....:.|:.::.....|::|.:... .|.|
Human   136 AELLAEEAGIALVPWGCPWTQAEGTTAPAVTPAADALYALLRAFGWARVALVTAPQDLW------ 194

  Fly   378 AANLHVPYRIEIGRTIRD-LHSQDKPGKAIIITAPLNDASTILLLSTIELDWTEQARKDGQGSRP 441
                     :|.||::.. |.::..|..::....||:.:..           .|..||...|.|.
Human   195 ---------VEAGRSLSTALRARGLPVASVTSMEPLDLSGA-----------REALRKVRDGPRV 239

  Fly   442 ------------GRQHTKILL-----IDMAASSL-----DTQHGFYKYLSRMGGSQSDAFARNTG 484
                        |.:..:.||     :.:...||     ||.|    |....|.....|.|.:
Human   240 TAVIMVMHSVLLGGEEQRYLLEAAEELGLTDGSLVFLPFDTIH----YALSPGPEALAALANS-- 298

  Fly   485 SPAEVVSSNLLVLTLLNDRHRLFLNAAGLMATMQNFRAPLNGNYKDPPPSGHRNASLHKLYPYRN 549
              :::..::..||||  .||                 .|..|:..|..........|......:.
Human   299 --SQLRRAHDAVLTL--TRH-----------------CPSEGSVLDSLRRAQERRELPSDLNLQQ 342

  Fly   550 LLPLYDTIVTTTTQSDTSETSPQFDFV-----------------------VLDIVRDAPVATY-- 589
            :.||:.||               :|.|                       |...:|||.|..:
Human   343 VSPLFGTI---------------YDAVFLLARGVAEARAAAGGRWVSGAAVARHIRDAQVPGFCG 392

  Fly   590 -----KWRPLLILESDPGSRGGGSVVEGGGSYISHSIHPGYDEWLLVSSVLLWQCGA-------I 642
                 :..|.::|::|         ..|...:.::.:.|....:|...:.:.:..|.       .
Human   393 DLGGDEEPPFVLLDTD---------AAGDRLFATYMLDPARGSFLSAGTRMHFPRGGSAPGPDPS 448

  Fly   643 CW-TIAAIC--------VCLLVIMIAGIVAGGIAMRNY----FLRKRLSKGPNKIVLSASDFVFP 694
            || ....||        |.|..:::.|:...|..:.:|    .|..::..|||||:|:..|..|
Human   449 CWFDPNNICGGGLEPGLVFLGFLLVVGMGLAGAFLAHYVRHRLLHMQMVSGPNKIILTVDDITF- 512

  Fly   695 VDSRRVDEGIEAMLCCWLQQLQEFGGPEVDKPDLLKGSIGSLKNLGFVIPGAAAPGSAGAITTTA 759
                                |...||..      .|.:.||..:||           |.:::...
Human   513 --------------------LHPHGGTS------RKVAQGSRSSLG-----------ARSMSDIR 540

  Fly   760 NGKSGSSATGSLARHNPAHLDMR--ARYNGDLVQLKEVNINGSAELRTKAMDLLVMAHGLRHENI 822
            :|.|             .|||..  ..|.||.|.||:...:....:|............|||||:
Human   541 SGPS-------------QHLDSPNIGVYEGDRVWLKKFPGDQHIAIRPATKTAFSKLQELRHENV 592

  Fly   823 NPLIG-------------WLSDPNRTAMVFDYCSRGSLQDVLIMDEIKLDWSFRLSLLTDLVRGM 874
            ...:|             |   ....|:|.::|:||||||:|...||||||.|:.|||.||::|:
Human   593 ALYLGLFLARGAEGPAALW---EGNLAVVSEHCTRGSLQDLLAQREIKLDWMFKSSLLLDLIKGI 654

  Fly   875 RYLHTSPLRVHGALTSRNCVVDARWVLKITDYGLNSFYESQGLPPRTRSAKELLWTAPELLRNMK 939
            ||||...: .||.|.||||:||.|:||||||:|.....|:|.:.|....|::.|||||||||:..
Human   655 RYLHHRGV-AHGRLKSRNCIVDGRFVLKITDHGHGRLLEAQKVLPEPPRAEDQLWTAPELLRDPA 718

  Fly   940 LHQHHHQHGRIQLGTQLGDVYSFGIIMQEVVVRGEPYCMLSLSPEEIIVKIKKPPPLIRPSVSKG 1004
            |.:.         ||..|||:|..|||||||.|..||.||.|:|||::.:::.||||.||.||..
Human   719 LERR---------GTLAGDVFSLAIIMQEVVCRSAPYAMLELTPEEVVQRVRSPPPLCRPLVSMD 774

  Fly  1005 AAPPEAINIMRQCWAEQPDMRPDFNSVYERFKMLNHGRKVNFVDTMFQMLEKYSNNLEELIRERT 1069
            .||.|.|.:|:|||||||::||..:..::.||.:|.|||.|.:|:|.:|||:||:|||:||||||
Human   775 QAPVECILLMKQCWAEQPELRPSMDHTFDLFKNINKGRKTNIIDSMLRMLEQYSSNLEDLIRERT 839

  Fly  1070 EQLDIERKKTEQLLNRMLPSSVAEKLKMGLAVDPEEFSDVTIYFSDIVGFTTIAAHCSPVQVVDL 1134
            |:|::|::||::||.:|||.||||.||.|..|:||.|..||:|||||||||||:|...|::||||
Human   840 EELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQVTLYFSDIVGFTTISAMSEPIEVVDL 904

  Fly  1135 LNDLYTIFDATINAYNVYKVETIGDAYMVVSGLPVKIPD-HAEQIATMALDLLHQSGRFNVKHLP 1198
            ||||||:|||.|.:::|||||||||||||.||||.:... ||.:||.|:||:|...|.|.::|:|
Human   905 LNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGTFRMRHMP 969

  Fly  1199 GVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGSSWRIHMSQETRDRLDA-RGG 1262
            .||:::|||||:|||.||||||||||||||||||||||||||||..:|||::..|...|.| ..|
Human   970 EVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSG 1034

  Fly  1263 YAIEPRGLIDIKGKGMMNTFWLLGKKGFDKPLPAPP---PIGESHGL 1306
            |.:|.||..::||||..:||||:|::||:||:|.||   |...:||:
Human  1035 YQVELRGRTELKGKGAEDTFWLVGRRGFNKPIPKPPDLQPGSSNHGI 1081

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	Protein Kinases, catalytic domain	763..1041	CDD:473864	123/292 (42%)
		HNOBA	<1047..1095	CDD:462234	30/47 (64%)
		CYCc	1074..1266	CDD:214485	123/193 (64%)
GUCY2D	NP_000171.1	PBP1_sensory_GC_DEF-like	55..431	CDD:380594	65/371 (18%)
		PK_GC-2D	536..811	CDD:270945	124/300 (41%)
		HNOBA	<820..865	CDD:462234	29/44 (66%)
		CYCc	846..1036	CDD:214485	121/189 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1065..1103		7/17 (41%)