Protein Alignment CG34357 and GUCY2F

DIOPT Version :9

• Sequence 1: NP_001356914.1
• Gene: CG34357 / 5740349
• FlyBaseID: FBgn0085386
• Length: 1689
• Species: Drosophila melanogaster
• Sequence 2: NP_001513.2
• Gene: GUCY2F / 2986
• HGNCID: 4691
• Length: 1108
• Species: Homo sapiens
• Alignment Length: 1130
• Identity: 405/1130 - (35%)
• Similarity: 554/1130 - (49%)
• Gaps: 277/1130 - (24%)

  Fly   308 GHCHQLAEQLALDFNKTVVLWPCPRM----KIS----SNFLPSFEAISLAVQSISTKLNWSQVDI 364
            |:| :.|..|...::|.:..|.|...    |||    |..|||...:.:.|...   ..|:...:
Human   130 GYC-EAASLLGNSWDKGIFSWACVNYELDNKISYPTFSRTLPSPIRVLVTVMKY---FQWAHAGV 190

  Fly   365 YIGD-DNWGLGLAIAANLHVPYRIEIGRTIRDLHSQDKPGKAIIITAPLNDASTILLLSTIELDW 428
            ...| |.|         :|...|:...     |.|...|...::.|.
Human   191 ISSDEDIW---------VHTANRVASA-----LRSHGLPVGVVLTTG------------------ 223

  Fly   429 TEQARKDGQGSRPG----RQHTKILLIDMAASSLDTQHGFYKYLSRMGGSQSDAFARNTGSPAEV 489
                 :|.|..|..    .|..:|.:|.|...|           :.:||...
Human   224 -----QDSQSMRKALQRIHQADRIRIIIMCMHS-----------ALIGGETQ------------- 259

  Fly   490 VSSNLLVLTLLNDRHRLFLNAAGLMATMQNFRAPLNGNYKDPPPSGHRNASLHKLYPYR------ 548
                   :.||...|.|.:.               :|.|...|......:..:|..|||
Human   260 -------MHLLECAHDLKMT---------------DGTYVFVPYDALLYSLPYKHTPYRVLRNNP 302

  Fly   549 NLLPLYDTIVTTTTQS----------------------DTSETSPQFDFVVLDIVRDAPVATYKW 591
            .|...||.::|.|.:|                      :..:.||.|..:...|...|.......
Human   303 KLREAYDAVLTITVESQEKTFYQAFTEAAARGEIPEKLEFDQVSPLFGTIYNSIYFIAQAMNNAM 367

  Fly   592 RPLLILESDPGSRGGGSVVEGGGSYISHSIHP---------GYDEWLLVSSVLL-WQ-------- 638
            :       :.|..|..|:|:...:...|..:.         |..|::::.:.|. |:
Human   368 K-------ENGQAGAASLVQHSRNMQFHGFNQLMRTDSNGNGISEYVILDTNLKEWELHSTYTVD 425

  Fly   639 ----------------------CGAICW------------TIAAICVCLLVIMIAGIVAGGIAMR 669
                                  ..|.||            ...|:.|| |.::||.:...|.|
Human   426 MEMELLRFGGTPIHFPGGRPPRADAKCWFAEGKICHGGIDPAFAMMVC-LTLLIALLSINGFA-- 487

  Fly   670 NYFLRKRLS-----KGPNKIVLSASD--FVFPVDSRRVDEGIEAMLCCWLQQLQEFGGPEVDKPD 727
             ||:|:|::     ||||:|:|:..|  |:.|                      .||...
Human   488 -YFIRRRINKIQLIKGPNRILLTLEDVTFINP----------------------HFGSKR----- 524

  Fly   728 LLKGSIGSLKNLGFVIPGAAAPGSAGAITTTANGKSGSSATGSL--ARHNPAHLDMRARYNGDLV 790
                  ||..::.|.|......|.:..:         |.::|||  |.:..:::   |.|.||.|
Human   525 ------GSRASVSFQITSEVQSGRSPRL---------SFSSGSLTPATYENSNI---AIYEGDWV 571

  Fly   791 QLKEVNINGSAEL---RTKAMDLLVMAHGLRHENINPLIGWLSDPNRTAMVFDYCSRGSLQDVLI 852
            .||:.::....:|   :::|.|:..|...|||||||||:|:..|....|:|.::||||||:|:|.
Human   572 WLKKFSLGDFGDLKSIKSRASDVFEMMKDLRHENINPLLGFFYDSGMFAIVTEFCSRGSLEDILT 636

  Fly   853 MDEIKLDWSFRLSLLTDLVRGMRYLHTSPLRVHGALTSRNCVVDARWVLKITDYGLNSFYESQGL 917
            ..::||||.|:.|||.||::||:|||.... |||.|.|||||||.|:|||:||||.|...|...|
Human   637 NQDVKLDWMFKSSLLLDLIKGMKYLHHREF-VHGRLKSRNCVVDGRFVLKVTDYGFNDILEMLRL 700

  Fly   918 PPRTRSAKELLWTAPELLRNMKLHQHHHQHGRIQLGTQLGDVYSFGIIMQEVVVRGEPYCMLSLS 982
            .....|.:|||||||||||..:         ..:||:..||||||.||||||:|||.|:||:.|.
Human   701 SEEESSMEELLWTAPELLRAPR---------GSRLGSFAGDVYSFAIIMQEVMVRGTPFCMMDLP 756

  Fly   983 PEEIIVKIKKPPPLIRPSVSKGAAPPEAINIMRQCWAEQPDMRPDFNSVYERFKMLNHGRKVNFV 1047
            .:|||.::|||||:.||.|....||||.:.:|:|||||..:.||.|:.::.:||..|.|:|.|.:
Human   757 AQEIINRLKKPPPVYRPVVPPEHAPPECLQLMKQCWAEAAEQRPTFDEIFNQFKTFNKGKKTNII 821

  Fly  1048 DTMFQMLEKYSNNLEELIRERTEQLDIERKKTEQLLNRMLPSSVAEKLKMGLAVDPEEFSDVTIY 1112
            |:|.:|||:||:|||:|||||||:|:||::|||:||.:|||.||||.||.|..|:||.|..||:|
Human   822 DSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLY 886

  Fly  1113 FSDIVGFTTIAAHCSPVQVVDLLNDLYTIFDATINAYNVYKVETIGDAYMVVSGLPVKIPD-HAE 1176
            ||||||||||:|...|::||||||||||:|||.|.:::|||||||||||||.||||.:... ||.
Human   887 FSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAA 951

  Fly  1177 QIATMALDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMEST 1241
            :||.|:||:|...|.|.::|:|.||:::|||||:||..|||||||||||||||||||||||||||
Human   952 EIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMEST 1016

  Fly  1242 GSSWRIHMSQETRDRL-DARGGYAIEPRGLIDIKGKGMMNTFWLLGKKGFDKPLPAPPPIGE--- 1302
            |..:|||:|..|...| :...||.:|.||..::||||...||||:|||||.||||.|||:.:
Human  1017 GLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWLIGKKGFMKPLPVPPPVDKDGQ 1081

  Fly  1303 -SHGL-------------DESLIRN 1313
             .|||             :..|:||
Human  1082 VGHGLQPVEIAAFQRRKAERQLVRN 1106

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	134/282 (48%)
		CYCc	1074..1266	CDD:214485	124/193 (64%)
GUCY2F	NP_001513.2	PBP1_sensory_GC_DEF_like	54..435	CDD:107366	66/398 (17%)
		ANF_receptor	75..412	CDD:279440	64/375 (17%)
		PKc_like	545..815	CDD:304357	134/291 (46%)
		HNOBA	<824..869	CDD:285003	31/44 (70%)
		CYCc	848..1040	CDD:214485	123/191 (64%)
		Guanylate_cyc	875..1062	CDD:278633	118/186 (63%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	237	1.000	Domainoid score	I2319
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	1	1.000	-	-		FOG0002312
OrthoInspector	1	1.000	-	-		otm42241
orthoMCL	1	0.900	-	-		OOG6_103194
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4933
SonicParanoid	1	1.000	-	-		X1738
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.810