Protein Alignment CG34357 and GUCY1B1

DIOPT Version :10

• Sequence 1: NP_001356914.1
• Gene: CG34357 / 5740349
• FlyBaseID: FBgn0085386
• Length: 1689
• Species: Drosophila melanogaster
• Sequence 2: XP_011530203.1
• Gene: GUCY1B1 / 2983
• HGNCID: 4687
• Length: 662
• Species: Homo sapiens
• Alignment Length: 296
• Identity: 103/296 - (34%)
• Similarity: 148/296 - (50%)
• Gaps: 62/296 - (20%)

  Fly  1052 QMLEKYSNNLE-ELIRERTE----QLDIERKKTE------------------------------- 1080
            |..|:|....| |::.:|.:    .|:.|:|||:
Human   358 QFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTGCPARIQAFKVQTTLMLCEKDSRSTKGFPS 422

  Fly  1081 ------------QLLNRMLPSSVAEKLKMGLAVDPEEFSDVTIYFSDIVGFTTIAA-HCS---PV 1129
                        :||..:||.|||.:|:....|..:.:.:|||.||.||||....: |.|   .:
Human   423 ISYSGFLLIPLNRLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAM 487

  Fly  1130 QVVDLLNDLYTIFDATINAYN---VYKVETIGDAYMVVSGLPVKIPDHAEQIATMALDLLHQSGR 1191
            ::|:|||||||.||...::..   ||||||:||.||.|||||.....||..|..:|||::..:|:
Human   488 KIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQ 552

  Fly  1192 FNVKHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGSSWRIHMSQETRDR 1256
            ..|   .|..:|:.||:|||....||:|..||||||||:|||..||.|:||...:|::|:.|...
Human   553 VQV---DGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRC 614

  Fly  1257 L----DARGGYAIEPRGLIDIKGKGMMNTFWLLGKK 1288
            |    ::...:.:|.||.:.:|||......|.|.:|
Human   615 LMSPENSDPQFHLEHRGPVSMKGKKEPMQVWFLSRK 650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	Protein Kinases, catalytic domain	763..1041	CDD:473864
		HNOBA	<1047..1095	CDD:462234	18/90 (20%)
		CYCc	1074..1266	CDD:214485	87/245 (36%)
GUCY1B1	XP_011530203.1	HNOB	2..166	CDD:462233
		HNOBA	207..449	CDD:462234	18/90 (20%)
		Guanylate_cyc	455..648	CDD:425528	82/195 (42%)