Protein Alignment CG34357 and Adcy8

DIOPT Version :10

• Sequence 1: NP_001356914.1
• Gene: CG34357 / 5740349
• FlyBaseID: FBgn0085386
• Length: 1689
• Species: Drosophila melanogaster
• Sequence 2: NP_058838.1
• Gene: Adcy8 / 29241
• RGDID: 2036
• Length: 1248
• Species: Rattus norvegicus
• Alignment Length: 379
• Identity: 115/379 - (30%)
• Similarity: 172/379 - (45%)
• Gaps: 80/379 - (21%)

  Fly  1028 FNSVYERFKMLNHGRKVNFVDT---------MF--------QMLEKYSNNLEELIR-----ERTE 1070
            :..::..:..|||..: :|:.|         ||        |.|| |:..|:.|.|     |..|
  Rat   874 YAGLFLSYDNLNHSGE-DFLGTKEASLLLMAMFLLAVFYHGQQLE-YTARLDFLWRVQAKEEINE 936

  Fly  1071 QLDIERKKTEQLLNRMLPSSVA----EKLKMGLAVDPEEFSDVTIYFSDIVGFTTIAAHC----S 1127
            ..|: |:..|.:|..:||..||    ||.:....:..:.:..|.:.|:.|.||....:..    .
  Rat   937 MKDL-REHNENMLRNILPGHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQ 1000

  Fly  1128 PVQVVDLLNDLYTIFDATINA---YNVYKVETIGDAYMVVSGL-PVKIP-----DHAEQIATMAL 1183
            .|:.:.|||::...||..:..   .::.|::|||..||.|||| |.|..     .|...:|..:|
  Rat  1001 GVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSL 1065

  Fly  1184 DLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGSSWRIH 1248
            .|.......| ||... ..:||||:..|...|||:|...|:|.::|.|||.||||:|||.|.||.
  Rat  1066 ALTESIQEIN-KHSFN-NFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQ 1128

  Fly  1249 MSQET----RDRLDARGGYAIEPRGLIDIKG----KGMMNTFWLLGKKGFDKPLPAPP---PIGE 1302
            :.:||    :|:     |:|.:.||.|.:||    :|.:.|::|||:.. ..|...||   | |:
  Rat  1129 VPEETYLILKDQ-----GFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQ-PNPFILPPRRLP-GQ 1186

  Fly  1303 SH------GLDESLIR-----------NSITLKAQANKSRTSTNPSSSQSSSLA 1339
            ..      ||.:||.|           ||..:|:..|: ||...||..:..:.|
  Rat  1187 YSLAAVVLGLVQSLNRQRQKQLLNENSNSGIIKSHYNR-RTLLTPSGPEPGAQA 1239

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	Protein Kinases, catalytic domain	763..1041	CDD:473864	2/12 (17%)
		HNOBA	<1047..1095	CDD:462234	21/73 (29%)
		CYCc	1074..1266	CDD:214485	69/212 (33%)
Adcy8	NP_058838.1	Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000269|PubMed:16258073, ECO:0000269|PubMed:22494970, ECO:0000269|PubMed:22976297	1..179
		Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000269|PubMed:22976297	1..106
		Essential for CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073	38..40
		Essential for CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073	49..51
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	51..117
		AcyC	211..564	CDD:441717
		Guanylate_cyc	402..586	CDD:425528
		Adcy_cons_dom	614..709	CDD:461877
		Guanylate_cyc	970..1169	CDD:425528	68/205 (33%)
		Involved in CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073	1106..1248		48/142 (34%)
		Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000269|PubMed:19305019	1197..1212		3/14 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1220..1248		6/21 (29%)