Protein Alignment CG34357 and Gucy2c

DIOPT Version :10

• Sequence 1: NP_001356914.1
• Gene: CG34357 / 5740349
• FlyBaseID: FBgn0085386
• Length: 1689
• Species: Drosophila melanogaster
• Sequence 2: NP_037302.1
• Gene: Gucy2c / 25711
• RGDID: 2771
• Length: 1072
• Species: Rattus norvegicus
• Alignment Length: 1110
• Identity: 326/1110 - (29%)
• Similarity: 507/1110 - (45%)
• Gaps: 288/1110 - (25%)

  Fly   317 LALDFNKTV--VLWPCPRMKISSNFLPSFEAISLAVQSISTKLNWSQVDIYIG-----DDNWGLG 374
            |:.|:.:|:  :|.|..::..   ||..|..::.|  ...| .:|:...:|..     |..|.|.
  Rat   148 LSCDYKETLTRILPPARKLMY---FLVDFWKVNNA--PFKT-FSWNSSYVYKNGSEPEDCFWYLN 206

  Fly   375 LAIAANLHVPYRIEIGRTIRDLHSQDKPGKAIIITAPLNDASTILLLSTIELDWTEQARKDGQGS 439
               |....|.|..|: .:.:|:..:.:..:.|::..  |..|.::::.     .|.:...:.:|.
  Rat   207 ---ALEAGVSYFSEV-LSFKDVLRRSEQFQEILMGR--NRKSNVIVMC-----GTPETFYNVKGD 260

  Fly   440 RPGRQHTKILLIDMAASSLDTQHGFYKYLSRMGGSQSDAFARNTGSPAEVVSSNLLVLTLLNDRH 504
            ......|.::|:|:.::..                    |..:|.:|..:  .|:|||||
  Rat   261 LKVADDTVVILVDLFSNHY--------------------FEDDTRAPEYM--DNVLVLTL----- 298

  Fly   505 RLFLNAAGLMATMQNFRAPLNGNYKDPPPSGHRNASLHKLYP---------YRNLLPLYDTIVTT 560
                                      ||.....|||:...:|         |.....|:..::.|
  Rat   299 --------------------------PPEKFIANASVSGRFPSERSDFSLAYLEGTLLFGHMLQT 337

  Fly   561 TTQSDTSETSPQF-------DF------VVLDIVRD---------APVATYKWRPLLILESDPGS 603
            ..::..|.|:|:|       .|      |.||...|         ..:.|.|::.|:..::   .
  Rat   338 FLENGESVTTPKFARAFRNLTFQGLEGPVTLDDSGDIDNIMCLLYVSLDTRKYKVLMAYDT---H 399

  Fly   604 RGGGSVVEGGGSYI--SHSIH---PGYDEWLLVSSVLLWQCGAICWTIAAICVCLLVIMIAGIVA 663
            :.....|....::|  :|.:.   ||....:|:.:|         :|:..|.|.||:|.:
  Rat   400 KNQTIPVATSPNFIWKNHRLPNDVPGLGPQILMIAV---------FTLTGIVVVLLLIAL----- 450

  Fly   664 GGIAMRNY-----FLRKRLSKGPNKIVLSASDFVFPV-------------DSRRVDEGIEAMLCC 710
              :.:|.|     ..:|:.|..|       |:.:||:             |.||.|.
  Rat   451 --LVLRKYRRDHELRQKKWSHIP-------SENIFPLETNETNHVSLKIDDDRRRDT-------- 498

  Fly   711 WLQQLQEFGGPEVDKPDLLKGSIGSLKNLGFVIPGAAAPGSAGAITTTANGKSGSSATGSLARHN 775
             :|::::.   :.||..::      ||:|
  Rat   499 -IQRVRQC---KYDKKKVI------LKDL------------------------------------ 517

  Fly   776 PAHLDMRARYNGDLVQLKEVNINGSAELRTKAMDLLVMAHGLRHENINPLIGWLSDPNRTAMVFD 840
             .|.|      |:..:.:::.:|           .|:.:.   :.|:....|.:....|...|.:
  Rat   518 -KHCD------GNFSEKQKIELN-----------KLLQSD---YYNLTKFYGTVKLDTRIFGVVE 561

  Fly   841 YCSRGSLQDVL-----IMDEIKLDWSFRLSLLTDLVRGMRYLHTSPLRVHGALTSRNCVVDARWV 900
            ||.||||::||     ..|...:||.|::|:|.|:.:||.|||:|.:.|||.|.|.|||||:|.|
  Rat   562 YCERGSLREVLNDTISYPDGTFMDWEFKISVLNDIAKGMSYLHSSKIEVHGRLKSTNCVVDSRMV 626

  Fly   901 LKITDYGLNSFYESQGLPPRTRSAKELLWTAPELLRNMKLHQHHHQHGRIQLGTQLGDVYSFGII 965
            :||||:|.||.     |||     |:.||||||.||...:             :|.||||||.||
  Rat   627 VKITDFGCNSI-----LPP-----KKDLWTAPEHLRQATI-------------SQKGDVYSFSII 668

  Fly   966 MQEVVVRGEPYCMLSLSPE-EIIVKIK-----KPPPLIRPSVSKGAAPPEAINI---MRQCWAEQ 1021
            .||:::|.|.:..||...: |.|.:::     ||   .||.:....|..:.:.:   ::.||.|.
  Rat   669 AQEIILRKETFYTLSCRDQNEKIFRVENSYGTKP---FRPDLFLETADEKELEVYLLVKSCWEED 730

  Fly  1022 PDMRPDFNSVYER----FKMLNHGRKVNFVDTMFQMLEKYSNNLEELIRERTEQLDIERKKTEQL 1082
            |:.||||..:...    |.:.:..:..:::||:.:.|:.||.|||.|:.|||:....||.:.:.|
  Rat   731 PEKRPDFKKIESTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADHL 795

  Fly  1083 LNRMLPSSVAEKLKMGLAVDPEEFSDVTIYFSDIVGFTTIAAHCSPVQVVDLLNDLYTIFDATIN 1147
            ...:||..|.:.||....|:||.:.:||||||||||||||..:.:|::|||:|||:|..||..::
  Rat   796 NFMLLPRLVVKSLKEKGIVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDQIVD 860

  Fly  1148 AYNVYKVETIGDAYMVVSGLPVKIPD-HAEQIATMALDLLHQSGRFNVKHLPGVPLQLRIGLHTG 1211
            .::|||||||||||:|.||||::..: ||..|:.||||:|...|.|.::||||:|:.:|||:|:|
  Rat   861 HHDVYKVETIGDAYVVASGLPMRNGNRHAVDISKMALDILSFMGTFELEHLPGLPVWIRIGVHSG 925

  Fly  1212 PCCAGVVGLTMPRYCLFGDTVNTASRMESTGSSWRIHMSQET---RDRLDARGGYAIEPRGLIDI 1273
            ||.|||||:.|||||||||||||||||||||...|||||..|   ..|.|.:  :..|.||...:
  Rat   926 PCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHMSSSTIAILRRTDCQ--FLYEVRGETYL 988

  Fly  1274 KGKGMMNTFWLLGKKGFDKPLPAPPPIGESHGLD---ESLIRNSITLKAQAN--KSRTSTNPSSS 1333
            ||:|...|:||.|.|..:..||.||.:.....|.   ..:|.:::. |.||:  |||..|..:|.
  Rat   989 KGRGTETTYWLTGMKDQEYNLPTPPTVENQQRLQTEFSDMIVSALQ-KRQASGVKSRRPTRVASY 1052

  Fly  1334 QSSSL 1338
            :...|
  Rat  1053 KKGFL 1057

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	Protein Kinases, catalytic domain	763..1041	CDD:473864	92/295 (31%)
		HNOBA	<1047..1095	CDD:462234	18/47 (38%)
		CYCc	1074..1266	CDD:214485	107/195 (55%)
Gucy2c	NP_037302.1	Periplasmic_Binding_Protein_type1	34..414	CDD:471960	59/338 (17%)
		Protein Kinases, catalytic domain	479..749	CDD:473864	101/370 (27%)
		CYCc	787..978	CDD:214485	107/192 (56%)