Protein Alignment CG34357 and Npr1

DIOPT Version :10

• Sequence 1: NP_001356914.1
• Gene: CG34357 / 5740349
• FlyBaseID: FBgn0085386
• Length: 1689
• Species: Drosophila melanogaster
• Sequence 2: NP_036745.1
• Gene: Npr1 / 24603
• RGDID: 3195
• Length: 1057
• Species: Rattus norvegicus
• Alignment Length: 1017
• Identity: 337/1017 - (33%)
• Similarity: 484/1017 - (47%)
• Gaps: 188/1017 - (18%)

  Fly   341 PSFEAISLAVQSISTKLNWSQ--VDIY---IGDDN------WGLGLAIAANL------------- 381
            ||...:...|.::..:|.|..  :.:|   :|||.      .||.:.:...|
  Rat   156 PSHVKLGDFVTALHRRLGWEHQALVLYADRLGDDRPCFFIVEGLYMRVRERLNITVNHQEFVEGD 220

  Fly   382 --HVPYRIEIGRTIRDLHSQDKPGKAI-IITAPLNDASTILLLSTIELDWTEQARKDGQGSRPGR 443
              |.|   ::.|.:|      :.|:.| |.::|  ||...|:|..:....|            |.
  Rat   221 PDHYP---KLLRAVR------RKGRVIYICSSP--DAFRNLMLLALNAGLT------------GE 262

  Fly   444 QHTKILLIDMAASSLDTQHGFYKYLSRMGGSQSDAFARNTGSPAEVVSSNLLVLTLLNDRHRLFL 508
            .:. ...:|:...||.:..|.........|...|..||.....|::::..    ...|..:..||
  Rat   263 DYV-FFHLDVFGQSLKSAQGLVPQKPWERGDGQDRSARQAFQAAKIITYK----EPDNPEYLEFL 322

  Fly   509 NAAGLMATMQNFRAPLNGNYKDPPPSGHRNASLHKLYPYRNLLPLYDTIVTTT-----TQSDTSE 568
            ....|:|. :.|...:....|:..|     ||.|      :.|.||...||.|     |.:|...
  Rat   323 KQLKLLAD-KKFNFTVEDGLKNIIP-----ASFH------DGLLLYVQAVTETLAQGGTVTDGEN 375

  Fly   569 TSPQF---------DFVVLDIVRDAPVATYKWRPLLILESDPGSRGGGSVVEGGGSYISHSIHPG 624
            .:.:.         .::.:|...|.......|      :.||         |.|...:..:.:..
  Rat   376 ITQRMWNRSFQGVTGYLKIDRNGDRDTDFSLW------DMDP---------ETGAFRVVLNYNGT 425

  Fly   625 YDEWLLVSS-VLLW----------QCG-----AIC-----WTIAAICVCLLVIMIAGIVAGGIAM 668
            ..|.:.||. .|.|          :||     ..|     .|:..:.:...:.:|:.::......
  Rat   426 SQELMAVSEHKLYWPLGYPPPDVPKCGFDNEDPACNQDHFSTLEVLALVGSLSLISFLIVSFFIY 490

  Fly   669 RNYFLRKRLSKGPNKIVLSASDFVFPVDSRRVDEGIEAMLCCWLQQLQEFGGPEVDKPDLLKGSI 733
            |...|.|.|                      |.|       .|..:.::.....:::
  Rat   491 RKMQLEKEL----------------------VSE-------LWRVRWEDLQPSSLER-------- 518

  Fly   734 GSLKNLGFVIPGAAAPGSAGAITTTANGKSGSSATGSLARHNPAHLDMRARYNGDLVQLKEVNIN 798
             .|::.|..:..:....:.|::.||.......:.|              |.|.|:||.:|.|| .
  Rat   519 -HLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKT--------------AYYKGNLVAVKRVN-R 567

  Fly   799 GSAELRTKAMDLLVMAHGLRHENINPLIGWLSDPNRTAMVFDYCSRGSLQDVLIMDEIKLDWSFR 863
            ...||..|.:..|.....:::|::...:|..:||....::.:||.||||||:|..:.|.|||.||
  Rat   568 KRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFR 632

  Fly   864 LSLLTDLVRGMRYLHTSPLRVHGALTSRNCVVDARWVLKITDYGLNSFYESQGLPPRTRSAKELL 928
            .||..|:|:||.:||...:..||.|.|.|||||.|:|||||||||.||.:.:.....|..||: |
  Rat   633 YSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDPEPEQGHTLFAKK-L 696

  Fly   929 WTAPELLRNMKLHQHHHQHGRIQLGTQLGDVYSFGIIMQEVVVRGEPYCM--LSLSPEEIIVKI- 990
            ||||||||.......         |:|.|||||||||:||:.:|...:.:  |.|||:|||.::
  Rat   697 WTAPELLRMASPPAR---------GSQAGDVYSFGIILQEIALRSGVFYVEGLDLSPKEIIERVT 752

  Fly   991 --KKPPPLIRPSVSKGAAPPEAINIMRQCWAEQPDMRPDFNSVYERFKMLNHGRKVNFVDTMFQM 1053
              ::||  .|||:...:...|...:|::||||.|..||.|..:....:..|.....|.:|.:...
  Rat   753 RGEQPP--FRPSMDLQSHLEELGQLMQRCWAEDPQERPPFQQIRLALRKFNKENSSNILDNLLSR 815

  Fly  1054 LEKYSNNLEELIRERTEQLDIERKKTEQLLNRMLPSSVAEKLKMGLAVDPEEFSDVTIYFSDIVG 1118
            :|:|:||||||:.|||:....|::|.|.||.::||.||||:||.|..|..|.|..||||||||||
  Rat   816 MEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVG 880

  Fly  1119 FTTIAAHCSPVQVVDLLNDLYTIFDATINAYNVYKVETIGDAYMVVSGLPVKIPD-HAEQIATMA 1182
            ||.::|..:|:|||.|||||||.|||.|:.::|||||||||||||||||||:... ||.::|.||
  Rat   881 FTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMA 945

  Fly  1183 LDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGSSWRI 1247
            |.||.....|.::|.|...|:||||:||||.|||||||.|||||||||||||||||||.|.:.:|
  Rat   946 LALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKI 1010

  Fly  1248 HMSQETRDRLDARGGYAIEPRGLIDIKGKGMMNTFWLLGKKG 1289
            |:|.||:..|:...|:.:|.||.:::||||.:.|:||||::|
  Rat  1011 HLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGERG 1052

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	Protein Kinases, catalytic domain	763..1041	CDD:473864	110/282 (39%)
		HNOBA	<1047..1095	CDD:462234	23/47 (49%)
		CYCc	1074..1266	CDD:214485	118/192 (61%)
Npr1	NP_036745.1	PBP1_NPR_A	32..439	CDD:380608	65/337 (19%)
		PK_GC-A_B	530..803	CDD:270944	113/299 (38%)
		HNOBA	<809..857	CDD:462234	23/47 (49%)
		CYCc	836..1025	CDD:214485	117/188 (62%)