DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34357 and Gucy2g

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	NP_620611.2	Gene:	Gucy2g / 245708	RGDID:	621853	Length:	1103	Species:	Rattus norvegicus

Alignment Length:	1099	Identity:	344/1099 - (31%)
Similarity:	483/1099 - (43%)	Gaps:	247/1099 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   310 CHQLAEQLALDFNKTVVLWPCP-------RMKISSNF--------LPSFEAISLAVQSISTKLNW 359
            |.:.||.:.|..::    |..|       ...:..:|        :|..:.|...::.....|.|
  Rat   126 CPEAAEVIGLLASE----WDIPLFDFVGQMTALEDHFWCDTCVTLVPPKQEIGTVLRESLQYLGW 186

  Fly   360 SQVDIYIGD---DNWG----LGLAIAANLHVPYRIEIGRTIR-------------DLHSQDKPGK 404
            ..:.::.|.   .:||    |..|:...|.:.:.|    |.|             .|.|.....:
  Rat   187 EYIGVFGGSSAGSSWGEVNELWKAVEDELQLHFTI----TARVRYSSGHSDLLQEGLRSMSSVAR 247

  Fly   405 AIIITAPLNDASTI----------------LLLSTIELDWTEQARKDGQGSRPGRQHTKILLI-- 451
            .||:.....||..|                |||..:|..:.::...:.:.:|..:.:..:.||
  Rat   248 VIILICSSEDAKHILQAAEDLGLNSREFVFLLLQQLEDSFWKEVLAEDKVTRFPKVYESVFLIAP 312

  Fly   452 ---DMAASSLDTQHGFYKYLSRMGGSQSDAFARNTGSP------------AEVVSSNLLVLTLLN 501
               ..:|...|.:...|:.| |....||...:.:..||            |:.|...:.......
  Rat   313 STYGGSAGDDDFRKQVYQRL-RRPPFQSSISSEDQVSPYSAYLHDALLLYAQTVEEMMKAEKDFR 376

  Fly   502 DRHRLFLNAAGLMATMQNFRAPLNGNYKDPPPSGHRNASLHKLYPYRN---LLPL--YDTIVTTT 561
            |..:|.........|:|....|:   ..|.....|.:.|::.|....|   .||.  ||:
  Rat   377 DGRQLISTLRADQVTLQGITGPV---LLDAQGKRHMDYSVYALQKSGNGSRFLPFLHYDS----- 433

  Fly   562 TQSDTSETSPQFDFVVLDIVRDAPVATYKWRPLLILESDPGSRGGGSVVEGGGSYISHSIHPGYD 626
                       |..|:           ..||      .|..:.|            .|..||.|.
  Rat   434 -----------FQKVI-----------RPWR------DDLNASG------------PHGSHPEYK 458

  Fly   627 EWLLVSSVLLWQCG---AICWT-----------IAAI--CVCLLVIMIAGIVAGGIAMRNYFLRK 675
            .          .||   .:|.|           :.|:  .|.|||:..|..:.|.:..|   ||.
  Rat   459 P----------DCGFHEDLCRTKPPTGAGMTASVTAVIPTVTLLVVASAAAITGLMLWR---LRG 510

  Fly   676 RLSKGPNKIVLSASDFVFPVDSRRVDEGIEAMLCCWLQQLQEFGGPEVDKPDLLKGSIGSLKNLG 740
            ::...|..                          .|.|       ...|...||.
  Rat   511 KVQNHPGD--------------------------TWWQ-------IHYDSITLLP---------- 532

  Fly   741 FVIPGAAAPGSAGAITTTANGKSGSSA-----TGSLARHNPAHLDMR------ARYNGDLVQLKE 794
                 ...|...|...:..|..:.|:.     .||.|:   .|.|..      ..|.|:.|.|
  Rat   533 -----QHKPSHRGTPMSRCNVSNASTVKISADCGSFAK---THQDEELFYAPVGLYQGNHVAL-- 587

  Fly   795 VNINGSAELRTKAMDLL----VMAHGLRHENINPLIGWLSDPNRTAMVFDYCSRGSLQDVLIMDE 855
            ..|...||.|.|...:|    :|.. |:||||.|..|..::|....:|...|.:|||:|||...:
  Rat   588 CYIGEEAEARIKKPTVLREVWLMCE-LKHENIVPFFGVCTEPPNICIVTQCCKKGSLKDVLRNSD 651

  Fly   856 IKLDWSFRLSLLTDLVRGMRYLHTSPLRVHGALTSRNCVVDARWVLKITDYGLNSFYESQGLPPR 920
            .::||.|:||.:.|:|.||.:||.||||.||.|...||:||:...||:..:||..|.........
  Rat   652 HEMDWIFKLSFVYDIVNGMLFLHGSPLRSHGNLKPSNCLVDSHMQLKLAGFGLWEFKHGSTCRIY 716

  Fly   921 TRSA---KELLWTAPELLRNMKLHQHHHQHGRIQLGTQLGDVYSFGIIMQEVV---VRGEPYCML 979
            .:.|   .||.||||||||..:|...         ||..||||||.|::::::   ..| |:..|
  Rat   717 NQEATDHSELYWTAPELLRLRELPWS---------GTPQGDVYSFAILLRDLIHQQAHG-PFEDL 771

  Fly   980 SLSPEEII--VKIKKPPPLIRPSVSKGAAPPEAINIMRQCWAEQPDMRPDFNSVYERFKMLNHGR 1042
            ..:|||||  :|..:.|..:|||:.:.......:.::|.||||.|:.||.|.|:.:..:..:...
  Rat   772 EAAPEEIISCIKDSRAPVPLRPSLLEDKGDERIVALVRACWAESPEQRPAFPSIKKTLREASPRG 836

  Fly  1043 KVNFVDTMFQMLEKYSNNLEELIRERTEQLDIERKKTEQLLNRMLPSSVAEKLKMGLAVDPEEFS 1107
            :|:.:|:|...||.|:::|||::.|||.||..|::|.|:||:.||||.|.|:|..|.:|:||.|.
  Rat   837 RVSILDSMMGKLEMYASHLEEVVEERTCQLVAEKRKVEKLLSTMLPSFVGEQLIAGKSVEPEHFE 901

  Fly  1108 DVTIYFSDIVGFTTIAAHCSPVQVVDLLNDLYTIFDATINAYNVYKVETIGDAYMVVSGLPVKI- 1171
            .|||:||||||||.:.:..||:|||.||||||::||.||..::|||||||||||||.||||::.
  Rat   902 SVTIFFSDIVGFTKLCSLSSPLQVVKLLNDLYSLFDHTIQTHDVYKVETIGDAYMVASGLPIRNG 966

  Fly  1172 PDHAEQIATMALDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTAS 1236
            ..||::||||:|.||..:..|.:.|:|...|:|||||||||..|||||:|||||||||||||.||
  Rat   967 AQHADEIATMSLHLLSVTTNFQIGHMPEERLKLRIGLHTGPVVAGVVGITMPRYCLFGDTVNMAS 1031

  Fly  1237 RMESTGSSWRIHMSQETRDRLDARGGYAIEPRGLIDIKGKGMMNTFWLLGKKGFDKPLP 1295
            ||||:....|||:||.|...|...|||.::.||.|.:||||...||||.||.||..|||
  Rat  1032 RMESSSLPLRIHVSQSTARALLVAGGYHLQKRGTISVKGKGEQTTFWLTGKDGFAVPLP 1090

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	104/300 (35%)
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	116/192 (60%)
Gucy2g	NP_620611.2	PBP1_GC_G_like	50..439	CDD:107367	61/351 (17%)
		ANF_receptor	66..417	CDD:279440	53/302 (18%)
		PK_GC	558..832	CDD:270894	103/289 (36%)
		CYCc	868..1058	CDD:214485	114/189 (60%)
		Guanylate_cyc	895..1081	CDD:278633	114/185 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820