DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34357 and Phlpp2

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	NP_001116066.2	Gene:	Phlpp2 / 244650	MGIID:	2444928	Length:	1355	Species:	Mus musculus

Alignment Length:	1012	Identity:	180/1012 - (17%)
Similarity:	336/1012 - (33%)	Gaps:	332/1012 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   787 GDLVQLKEVNINGS---------AELRTKAMDLLVMAHGLRHENINPLIGWLSDPNRTAMV---F 839
            |.|:.|:.::::|:         ..|| :...|.:..:..||  |..::..|:..::.||.   .
Mouse   374 GKLLNLQTLSLDGNGLTALPDELGNLR-QLTSLGISFNDFRH--IPEVLEKLTMLDKVAMAGNRL 435

  Fly   840 DYCSRGSLQDVLIMDEIKLDWSFRLSLLTDLVRGMRYLHTSPLRVHG----------ALTSRNCV 894
            :..:.|:|..:..:..:.|..:...:::|:.:.|.:::....||.:.          :|...:|.
Mouse   436 EVLNLGALTRMSQVKHVDLRMNHLKTVITENMEGNKHITHMDLRDNQLTDLDLSSLCSLEQLHCE 500

  Fly   895 VDARWVLKITDYGLNSFYESQGLPPRTRSAKELLWTAPELLRNMKLHQH---------------- 943
            .:....|.::.:.|.:.|.|.     .|.....::..|.||.:::|.|:
Mouse   501 RNQLRELTLSGFSLRTLYASW-----NRLTAVNVYPVPSLLTSLELSQNLLECVPDWACEAKKLE 560

  Fly   944 -----HHQHGRIQLGTQLGDVYSFGIIMQEVVVRGEPYCMLSLSPEEIIV---KIKKPPPLIRPS 1000
                 |:                   ::.||.:|    .:.|||..:::|   .|...|.|:.
Mouse   561 ILDISHN-------------------LLTEVPMR----ILSSLSLRKLMVGHNHIHVLPALVE-- 600

  Fly  1001 VSKGAAPPEAINIMRQCWAEQPDMRPDFNSVYERFKMLNHGRKVNFVDTMFQMLEKYSNNLEELI 1065
                ..|.|.::|.....:..||      :::.  |.||           .:.|...:|:||.
Mouse   601 ----HIPLEVLDIQHNTLSRLPD------TLFS--KALN-----------LRYLNASANSLES-- 640

  Fly  1066 RERTEQLDIERKKTEQLLNRMLPSSVAEKLKMGLAVDPEEFSDVTIYFSDIVGFTTIAAHCSPV- 1129
                                 |||:.|.:         |..|.:.:.:   :....:...|.||
Mouse   641 ---------------------LPSACAGE---------ESLSVLQLLY---LTSNLLTDQCIPVL 672

  Fly  1130 ------QVVDLLNDLYTIFDATINAYNVYKVETIGDAYM---VVSGLPVKIPDHAEQIATMALDL 1185
                  :|:.|.|:....|.|:    .:.|:|.:.:..:   .::.:|..|. :.:::.|:   :
Mouse   673 VGHPHLRVLHLANNQLQTFPAS----KLNKLEQLEELNLSGNKLTAIPTTIA-NCKRLHTL---V 729

  Fly  1186 LHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGSSWRIHMS 1250
            .|.:   |:...|.: |||.........|..:..:.:|.     ....|...::.||:: .:.:.
Mouse   730 AHAN---NISIFPEI-LQLPQIQFVDLSCNDLTEILIPE-----ALPATLQDLDLTGNT-NLVLE 784

  Fly  1251 QETRDRLDARGGYAIEPRGLIDIKGKGMMNTFWLLGKKGFDKPLPAPPPIGESHGLDESL-IRNS 1314
            .:|.|.........|:.:.| ......:.:|||                   ||||.|.. .||.
Mouse   785 HKTLDMFSHITALKIDQKPL-PATDSAVTSTFW-------------------SHGLAEMAGQRNK 829

  Fly  1315 ITLKAQA------------------------------------NKSRTSTNPS---------SSQ 1334
            :.:.|.|                                    .:.:.|||.:         |.:
Mouse   830 LCVSALAMDNFAEGVGAVYGMFDGDRNEELPRLLQCTMADVLLEEVQHSTNDTVFMTNTFLVSHR 894

  Fly  1335 SSSLAGE---SVEVKVEITPPTNADLASGTNLPNSYSLDSNSTNTISPNATLCPEFPGKTTPSS- 1395
            ...:||:   |..:...|.|.| ||..|      |:||  ...|.....|.||.  .||..|.|
Mouse   895 KLGMAGQKLGSSALLCYIRPDT-ADPTS------SFSL--TVANVGMCQAVLCR--GGKPVPLSK 948

  Fly  1396 ------TSPQSRKLSE----LTPENLLN-PNSFNRLPSSTGGSSSRLYKKI-------------- 1435
                  ...:::::.:    :|.:|.:| .....||...|     .||..|
Mouse   949 VFSLEHDPEEAQRVKDQKAIITEDNKVNGVTCCTRLLGCT-----YLYPWILPKPHIASTPLTIQ 1008

  Fly  1436 EEMMDLSSP--YNHYKCLSPSES---------------NLTQFYDGKYLYGSVAGGAGGGQAGGG 1483
            :|::.|.:.  :.|...|....:               .|.|.|..:...|::......|:. |.
Mouse  1009 DELLILGNKALWEHLSYLEAVNAVRHVQDPLAAAKKLCTLAQSYGCQDNVGAMVVYLNIGEE-GC 1072

  Fly  1484 ACASIALSGSGCGGGASRFDSK-------PGSSRLLRRQFSLDRDDQQAK---GEQQHHQHSLQA 1538
            .|....|:..|..|.||....|       |.||..:..:||.:....:..   |.....:|
Mouse  1073 TCEMNGLTLPGPVGFASTAALKDTPKPTTPSSSSGIASEFSSEMSTSEVSSEVGSTASDEH---- 1133

  Fly  1539 NTYSGLVGGCGGGVKSSMLDIP----LLHDTT------RSPKGTLTRSHKQNSASITQDLEKIEE 1593
            ||.         |:::|:|..|    .||..:      |.|......|::.::...:.|.:.:|.
Mouse  1134 NTV---------GLEASLLPRPERRCSLHPASSAGVFQRQPSCATFSSNQSDNGLDSDDDQPVEG 1189

  Fly  1594 IPLSPASSQHHSSLDSNLNRSPPSTLEAQSPPLPPMS 1630
            :..:.:..:....:.....|.|.|     |||||..|
Mouse  1190 VITNGSRVEVEVDIHCCRGREPES-----SPPLPKNS 1221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	51/299 (17%)
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	32/201 (16%)
Phlpp2	NP_001116066.2	PH_PHLPP-like	181..275	CDD:270131
		leucine-rich repeat	285..305	CDD:275380
		leucine-rich repeat	306..332	CDD:275380
		LRR_RI	309..548	CDD:238064	32/181 (18%)
		LRR_8	354..412	CDD:290566	7/38 (18%)
		leucine-rich repeat	356..378	CDD:275380	2/3 (67%)
		leucine-rich repeat	379..401	CDD:275380	4/22 (18%)
		leucine-rich repeat	402..424	CDD:275380	5/23 (22%)
		LRR_8	425..483	CDD:290566	9/57 (16%)
		leucine-rich repeat	425..448	CDD:275380	4/22 (18%)
		LRR_RI	447..714	CDD:238064	56/358 (16%)
		leucine-rich repeat	449..472	CDD:275380	3/22 (14%)
		leucine-rich repeat	474..493	CDD:275380	2/18 (11%)
		leucine-rich repeat	494..513	CDD:275380	3/18 (17%)
		leucine-rich repeat	514..535	CDD:275380	5/25 (20%)
		LRR_8	536..592	CDD:290566	11/78 (14%)
		leucine-rich repeat	536..558	CDD:275380	3/21 (14%)
		leucine-rich repeat	559..581	CDD:275380	5/44 (11%)
		leucine-rich repeat	582..597	CDD:275380	2/14 (14%)
		LRR_8	604..664	CDD:290566	17/113 (15%)
		leucine-rich repeat	604..627	CDD:275380	5/30 (17%)
		leucine-rich repeat	628..653	CDD:275380	9/56 (16%)
		leucine-rich repeat	654..677	CDD:275380	3/25 (12%)
		LRR_8	676..735	CDD:290566	11/69 (16%)
		leucine-rich repeat	678..701	CDD:275380	6/26 (23%)
		leucine-rich repeat	702..724	CDD:275380	2/22 (9%)
		leucine-rich repeat	747..768	CDD:275380	2/25 (8%)
		PP2Cc	816..1065	CDD:238083	51/283 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900