DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34357 and PHLPP1

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	NP_919431.2	Gene:	PHLPP1 / 23239	HGNCID:	20610	Length:	1717	Species:	Homo sapiens

Alignment Length:	1995	Identity:	357/1995 - (17%)
Similarity:	578/1995 - (28%)	Gaps:	825/1995 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 ASASASSSLSSSSSSSSHFHSEKPLHSDVLVLRAAKPSRAIATSADAATRSVPAS-AAETTLGSK 101
            |:|:||||.|||::::||                         |..||  .:||| :|..:|.::
Human   133 AAAAASSSSSSSAAAASH-------------------------SPGAA--GLPASCSASASLCTR 170

  Fly   102 SIWPTAIQTKSPRNAREAGRHKRQMQKPAIQQQPLQQQQQRINPPQQKRQQQQQQQQQVQHQAQR 166
            |:....:..|          |:                        |..|.|...:..|:||.||
Human   171 SLDRKTLLLK----------HR------------------------QTLQLQPSDRDWVRHQLQR 201

  Fly   167 VGVLIPPSLHVDLTHVQQGFQNFLDFFQLHLFNVTVDFLRDV-----DLSGFI--KLLEL-PKYT 223
                       ...||          |..|:.:.   :||.|     ..:|.:  :||:| .|..
Human   202 -----------GCVHV----------FDRHMAST---YLRPVLCTLDTTAGEVAARLLQLGHKGG 242

  Fly   224 SVIKTLNAGIMVASHVDVDQNSTIYIGTPSQPRQQ--HRLHSKQEQEPHRHHHEDSKAKQFP--- 283
            .|:|.|..|...|:..:           |::|..:  .||     ..|.....|...|:..|
Human   243 GVVKVLGQGPGAAAARE-----------PAEPPPEAGPRL-----APPEPRDSEVPPARSAPGAF 291

  Fly   284 ------------------------AGEEESHSS-GETEENHWNDARIFSGHCHQLAEQLALDFNK 323
                                    |....|.|| ||                         .|..
Human   292 GGPPRAPPADLPLPVGGPGGWSRRASPAPSDSSPGE-------------------------PFVG 331

  Fly   324 TVVLWP-CPRMKISSNFLPSFEAISLAVQSISTKLNWSQVDIYIGDDNWGLGLAIAANLHVPYRI 387
            ..|..| .||..:|..  .|| ::|.:.:|:|.:|:                         ||..
Human   332 GPVSSPRAPRPVVSDT--ESF-SLSPSAESVSDRLD-------------------------PYSS 368

  Fly   388 EIGRTIRDLHSQDKPGKAIIITAPLNDASTILLLSTIELDWTEQARKDGQGSRPGRQHTKILLID 452
            ..|.:     |..:..:|...:||..                    ..||..|||.. .:.|.:.
Human   369 GGGSS-----SSSEELEADAASAPTG--------------------VPGQPRRPGHP-AQPLPLP 407

  Fly   453 MAASSLDTQHGFYKYLSRMGGSQSDAFARNTGSPAEVVSSNLLVLTLLNDRHRLFLNAAGLMATM 517
            ..|||...|....:.:...||:..:.......:.|                    :...||.:|.
Human   408 QTASSPQPQQKAPRAIDSPGGAVREGSCEEKAAAA--------------------VAPGGLQSTP 452

  Fly   518 QNFRAPLNGNYKDPPPSGHRNASLHKLYPYRNLLP--LYDTIVTTTTQSDTSETSP--------- 571
            .  |:.:......|||.                 |  ||..:...||:...:|..|
Human   453 G--RSGVTAEKAPPPPP-----------------PPTLYVQLHGETTRRLEAEEKPLQIQNDYLF 498

  Fly   572 QFDFVVLDIVRDAPVATYKWRPLLILESDPGSRGGGSVVEGGGSYISHSIHPGYDEWLLVSSVLL 636
            |..|..|..|::..:.:.....:......|.|.|....::..|.|   ::..|           .
Human   499 QLGFGELWRVQEEGMDSEIGCLIRFYAGKPHSTGSSERIQLSGMY---NVRKG-----------K 549

  Fly   637 WQCGAICWTIAAICVCLLVIMIAGIVAGGIAMRNYFLRKRLSKGPNKIVLSASDFVFPVDSRRVD 701
            .|.....||...:.:|...::::.:                     |..|:....|.|:...:|:
Human   550 MQLPVNRWTRRQVILCGTCLIVSSV---------------------KDSLTGKMHVLPLIGGKVE 593

  Fly   702 EGIEAMLC---------------C---------WLQQLQEFGGPEVDKPDLLKGSIGSLKNL--- 739
            |..:...|               |         ||:|:.:.....:...||   |..||::|
Human   594 EVKKHQHCLAFSSSGPQSQTYYICFDTFTEYLRWLRQVSKVASQRISSVDL---SCCSLEHLPAN 655

  Fly   740 --------------GFVIPGAAAPGSAG----------------------------AITTTANGK 762
                          .|:....:.|.:.|                            :|.|.|...
Human   656 LFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNNHLGDFPLAVCSIPTLAELN 720

  Fly   763 SGSSATGSL-----ARHN--------------PAHLD--MRARYNG--------------DLVQL 792
            ...:|..|:     ..||              ||.|:  .:..|.|              .|..:
Human   721 VSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEKLTAV 785

  Fly   793 KEVNINGSAELRTKAMDLLVMAHGLRHEN--INPLIGWLSDP------------------NRTAM 837
            .::.::|:.....:...|..|.| ::|.:  :|.:...::|.                  :..||
Human   786 DKLCMSGNCVETLRLQALRKMPH-IKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAM 849

  Fly   838 VFD-----YCSRGSLQDVLIMDEIKLD-WSFRLSLL----TDLVR--------GMRYLHTSPLRV 884
            :|:     :|.|..|        :.|| ..:.|..|    .:||:        .:.|:..|..|:
Human   850 IFNNIEVLHCERNQL--------VTLDICGYFLKALYASSNELVQLDVYPVPNYLSYMDVSRNRL 906

  Fly   885 HGALTSRNCVVDARWV-----LKITDYGLNSFYESQGLPPR---TRSAKEL------LWTAPELL 935
            ...         ..||     |::.|.|.|...|   ||.|   ..|.::|      |...||.|
Human   907 ENV---------PEWVCESRKLEVLDIGHNQICE---LPARLFCNSSLRKLLAGHNQLARLPERL 959

  Fly   936 RNMKLHQHHHQHGR-IQLGTQLGDVYSFGIIMQEVVVRGEPYCMLSLSPEEIIVKIKKPPPLIRP 999
            ....:.....||.: ::|...|             :::.:....|:.|..    |::..||
Human   960 ERTSVEVLDVQHNQLLELPPNL-------------LMKADSLRFLNASAN----KLESLPP---- 1003

  Fly  1000 SVSKGAAPPEAINIMRQCWAEQPDMRPDFNSVYERFKMLNHGR-KVNFVDTMFQMLEKYSNN--- 1060
                .....|..:|:::.:...       ||:.::...|..|. .:..:...:..|:.:..:
Human  1004 ----ATLSEETNSILQELYLTN-------NSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMA 1057

  Fly  1061 -LEELIRERTEQLDIERKKTEQLLNRMLPSSVAEKLKMG--------LAVDPEEFSDVTIYFSDI 1116
             ||||     |::|:...|.     :.:|:::....:|.        :.|.||......|...|:
Human  1058 KLEEL-----EEIDLSGNKL-----KAIPTTIMNCRRMHTVIAHSNCIEVFPEVMQLPEIKCVDL 1112

  Fly  1117 ----VGFTTIAAHCSP-VQVVDLLNDLYTIFD----ATINAYNVYKVE--TIGDAYMVVSGLPVK 1170
                :...|:..:..| :|.:||..:...:.|    ..:|....:|::  :.|||    ||.|.
Human  1113 SCNELSEVTLPENLPPKLQELDLTGNPRLVLDHKTLELLNNIRCFKIDQPSTGDA----SGAPA- 1172

  Fly  1171 IPDHAEQIATMALDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYC-----LFG- 1229
            :..|....|:                  ||..:|         |  |..|::..:|     |:|
Human  1173 VWSHGYTEAS------------------GVKNKL---------C--VAALSVNNFCDNREALYGV 1208

  Fly  1230 ----DTVNTASRMESTGSSWRIHMSQETRDRLD------------------ARGGYA-------- 1264
                ..|.....::.|.|.......|:|::..:                  ..||.|
Human  1209 FDGDRNVEVPYLLQCTMSDILAEELQKTKNEEEYMVNTFIVMQRKLGTAGQKLGGAAVLCHIKHD 1273

  Fly  1265 -IEPRGLIDIKGKGMMNTFWLLGKKGFDKPLPAPPPIGESH--GLDESLIRNS-----ITLKAQA 1321
             ::|.|...:....:.....:|.:.|  |||    |:..|:  ..:|.|.|..     ||...:.
Human  1274 PVDPGGSFTLTSANVGKCQTVLCRNG--KPL----PLSRSYIMSCEEELKRIKQHKAIITEDGKV 1332

  Fly  1322 NKSRTST--------NPS-----SSQSSSLAGE---------------SVEVKVEI---TPPTNA 1355
            |....||        :||     ..||..|..:               |||..||.   .|...|
Human  1333 NGVTESTRILGYTFLHPSVVPRPHVQSVLLTPQDEFFILGSKGLWDSLSVEEAVEAVRNVPDALA 1397

  Fly  1356 DLASGTNLPNSYSL---------------DSNSTNTISPNATLCPEFPGKTTPSSTSPQSRKLSE 1405
            .......|..||..               ||.....:|....:.|..||...||
Human  1398 AAKKLCTLAQSYGCHDSISAVVVQLSVTEDSFCCCELSAGGAVPPPSPGIFPPS----------- 1451

  Fly  1406 LTPENLL---NPNSFNRLPSSTGGSSSRLYKKIEEMMDLSSPYNHYKCLSPSESNLTQFYDGKYL 1467
               .|::   .|:....:|||:.|.:|          ::||.      ||.||.:
Human  1452 ---VNMVIKDRPSDGLGVPSSSSGMAS----------EISSE------LSTSEMS---------- 1487

  Fly  1468 YGSVAGGAGGGQAGGGACAS---------------IALSGSGCGGGASRFDSKPGSSRLLRRQFS 1517
              |..|.....:...||.:.               |.||.|         ..:..||......||
Human  1488 --SEVGSTASDEPPPGALSENSPAYPSEQRCMLHPICLSNS---------FQRQLSSATFSSAFS 1541

  Fly  1518 ---LDRDDQQ----------------------AKGEQQHHQHSLQANTYSGLVGGCGGGVKSSML 1557
               ||.||::                      || |::..||.||....:    ...|.|.|:..
Human  1542 DNGLDSDDEEPIEGVFTNGSRVEVEVDIHCSRAK-EKEKQQHLLQVPAEA----SDEGIVISANE 1601

  Fly  1558 DIP-LLHDTTRSPKGTLTRSHKQNSASITQDLEKIEEI----PL--------SPAS--------- 1600
            |.| |......|..||:.|.....|.:..:....:.|:    ||        :||.
Human  1602 DEPGLPRKADFSAVGTIGRRRANGSVAPQERSHNVIEVATDAPLRKPGGYFAAPAQPDPDDQFII 1666

  Fly  1601 -----------SQHHSSLDSNLNRSPPSTLEAQSPPLPPMSPPQL 1634
                       .:||....           :.|.||.||...|||
Human  1667 PPELEEEVKEIMKHHQEQQ-----------QQQQPPPPPQLQPQL 1700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	62/365 (17%)
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	41/247 (17%)
PHLPP1	NP_919431.2	leucine-rich repeat	1107..1129	CDD:275380	3/21 (14%)
		PP2Cc	1168..1420	CDD:214625	54/287 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1458..1510		16/79 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1673..1717		10/39 (26%)
		PDZ-binding, required for interaction with SLC9A3R1. /evidence=ECO:0000269\|PubMed:21804599	1715..1717
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..118
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..156		12/46 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..470		55/351 (16%)
		PH_PHLPP-like	535..631	CDD:270131	17/130 (13%)
		PH	555..636	CDD:278594	14/101 (14%)
		LRR_RI	625..929	CDD:238064	53/324 (16%)
		LRR_8	638..703	CDD:290566	9/67 (13%)
		LRR 1	638..659		6/23 (26%)
		leucine-rich repeat	641..661	CDD:275380	6/22 (27%)
		LRR 2	661..682		2/20 (10%)
		leucine-rich repeat	662..692	CDD:275380	3/29 (10%)
		LRR 3	692..712		0/19 (0%)
		leucine-rich repeat	693..738	CDD:275380	5/44 (11%)
		LRR_8	714..770	CDD:290566	11/55 (20%)
		LRR 4	715..736		4/20 (20%)
		LRR 5	738..760		4/21 (19%)
		leucine-rich repeat	739..761	CDD:275380	3/21 (14%)
		LRR 6	761..783		2/21 (10%)
		leucine-rich repeat	762..784	CDD:275380	3/21 (14%)
		LRR 7	784..804		1/19 (5%)
		leucine-rich repeat	785..808	CDD:275380	3/22 (14%)
		LRR 8	808..831		4/23 (17%)
		leucine-rich repeat	810..832	CDD:275380	3/21 (14%)
		LRR_RI	814..1074	CDD:238064	56/321 (17%)
		LRR 9	832..853		3/20 (15%)
		leucine-rich repeat	833..853	CDD:275380	3/19 (16%)
		leucine-rich repeat	854..895	CDD:275380	9/48 (19%)
		LRR 10	873..894		4/20 (20%)
		LRR 11	895..916		5/29 (17%)
		leucine-rich repeat	896..918	CDD:275380	5/30 (17%)
		LRR 12	918..939		8/23 (35%)
		leucine-rich repeat	919..941	CDD:275380	8/24 (33%)
		LRR 13	941..962		6/20 (30%)
		leucine-rich repeat	942..963	CDD:275380	5/20 (25%)
		LRR_8	962..1024	CDD:290566	12/93 (13%)
		LRR 14	963..984		4/33 (12%)
		leucine-rich repeat	964..987	CDD:275380	4/35 (11%)
		LRR 15	987..1008		5/32 (16%)
		leucine-rich repeat	988..1011	CDD:275380	6/34 (18%)
		LRR 16	1013..1033		4/26 (15%)
		LRR_8	1014..1072	CDD:290566	11/69 (16%)
		leucine-rich repeat	1014..1037	CDD:275380	4/29 (14%)
		LRR 17	1037..1058		1/20 (5%)
		leucine-rich repeat	1038..1061	CDD:275380	2/22 (9%)
		LRR 18	1061..1082		6/30 (20%)
		Interaction with SLC9A3R1. /evidence=ECO:0000269\|PubMed:21804599	1076..1205		30/162 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900