Protein Alignment CG34357 and Npr2

DIOPT Version :10

• Sequence 1: NP_001356914.1
• Gene: CG34357 / 5740349
• FlyBaseID: FBgn0085386
• Length: 1689
• Species: Drosophila melanogaster
• Sequence 2: NP_776149.1
• Gene: Npr2 / 230103
• MGIID: 97372
• Length: 1047
• Species: Mus musculus
• Alignment Length: 1121
• Identity: 365/1121 - (32%)
• Similarity: 499/1121 - (44%)
• Gaps: 266/1121 - (23%)

  Fly   328 WPCPRMKISSNFLPSFEAISLAVQS-----------ISTKLN-----------------WSQVDI 364
            |..||:.         .|::|||::           :|::|:                 :...|:
Mouse    40 WAWPRVG---------PAVALAVEALGRALPVDLRFVSSELDGACSEYLAPLRAVDLKLYHDPDL 95

  Fly   365 YIGD-------------DNWGLGL----AIAA-----NLHVPYRIEIGRTIRDLHSQDKPGKAII 407
            .:|.             .:|.|.|    |:|:     |.|  ||    ..:|...|..|.|:.::
Mouse    96 LLGPGCVYPAASVARFASHWRLPLLTAGAVASGFAAKNEH--YR----TLVRTGPSAPKLGEFVV 154

  Fly   408 ITAPLNDASTILLLSTI--ELDWTEQ-------ARKDGQGSRPGRQHTKILLIDMAASSLDTQHG 463
                           |:  ..:||.:       ||.|   .||.....:.:...:..|:|..||
Mouse   155 ---------------TLHGHFNWTARAALLYLDARTD---DRPHYFTIEGVFEALQGSNLSVQH- 200

  Fly   464 FYKYLSRMGG-SQSDAFARNTG------SPAEVVSSNLLVL---TLLNDRHRLF--------LNA 510
             ..|....|| .|:..|.|..|      .|.|::...||..   .|.|..:..|        |.|
Mouse   201 -QVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRA 264

  Fly   511 AGLMAT----------------MQNFRAPLNGNYKDPPPSGHRNASLHKLYPYR----------- 548
            ....||                .:.|:..|...|::||...::......|...|
Mouse   265 GPTRATGRPWQDNRTQEQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSL 329

  Fly   549 -NLLP--LYDTIV-------TTTTQSDTSETSPQFDFVVLDIVRDAPVATYKWRPLLILESDPGS 603
             ||:.  .||.|:       .|..:..|.|..       |.||.......|.....|::......
Mouse   330 MNLIAGCFYDGILLYAQVLNETIQEGGTREDG-------LRIVEKMQGRRYHGVTGLVVMDKNND 387

  Fly   604 RGGGSVVEGGGSYISHSIHPGYDEWLLVSSVLLWQCGAICW------------------------ 644
            |....|:...|...|....|. ..:......:.|....|.|
Mouse   388 RETDFVLWAMGDLDSGDFQPA-AHYSGAEKQIWWTGRPIPWVKGAPPLDNPPCAFDLDDPSCDKT 451

  Fly   645 ---TIAAICVCLLVIMIAGIVAGGIAMRNYFLRKRLSKGPNKIVLSASDFVFPVDSRRVDEGIEA 706
               |:|.:.:...|..|...|:..:..|...|.|.|:                           :
Mouse   452 PLSTLAIVALGTGVTFIMFGVSSFLIFRKLMLEKELA---------------------------S 489

  Fly   707 MLCCWLQQLQE--FGGPEVDKPDLLKGSIGSLKNLGFVIPGAAAPGSAGAITTTANGKSGSSATG 769
            ||  |..:.:|  ||     ..|......||...|       :..||:.....||:||....|
Mouse   490 ML--WRIRWEELQFG-----NSDRYHKGAGSRLTL-------SLRGSSYGSLMTAHGKYQIFA-- 538

  Fly   770 SLARHNPAHLDMRARYNGDLVQLKEVNINGSAELRTKAMDLLVMAHGLRHENINPLIGWLSDPNR 834
                 |..|      :.|::|.:|.|| ....||..:.:..|.....::..::...||...||..
Mouse   539 -----NTGH------FKGNVVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPN 591

  Fly   835 TAMVFDYCSRGSLQDVLIMDEIKLDWSFRLSLLTDLVRGMRYLHTSPLRVHGALTSRNCVVDARW 899
            ..:|.:||.||||||:|..|.|.|||.||.||:.|||:||.:||.|.:..||:|.|.|||||:|:
Mouse   592 ICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRF 656

  Fly   900 VLKITDYGLNSFYESQGLPPRTRS--AKELLWTAPELLRNMKLHQHHHQHGRIQLGTQLGDVYSF 962
            |||||||||.|| .|...|..:.:  ||: ||||||||....|.         ..|.|..|||||
Mouse   657 VLKITDYGLASF-RSTAEPDDSHALYAKK-LWTAPELLSGNPLP---------TTGMQKADVYSF 710

  Fly   963 GIIMQEVVVRGEPYCM--LSLSPEEIIVKIKK-PPPLIRPSVSKGAAPPEAINIMRQCWAEQPDM 1024
            .||:||:.:|..|:.:  |.|||:||:.|::. ..|..|||:.:.....|.:.:|.:|||:.|..
Mouse   711 AIILQEIALRSGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPTE 775

  Fly  1025 RPDFNSVYERFKMLNHGRKVNFVDTMFQMLEKYSNNLEELIRERTEQLDIERKKTEQLLNRMLPS 1089
            ||||..:....:..|.....:.:|.:...:|:|:||||:|:.|||:....|::|.|.||.::||.
Mouse   776 RPDFGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPH 840

  Fly  1090 SVAEKLKMGLAVDPEEFSDVTIYFSDIVGFTTIAAHCSPVQVVDLLNDLYTIFDATINAYNVYKV 1154
            ||||:||.|..|..|.|..||||||||||||.::|..:|:|||.|||||||.|||.|:.::||||
Mouse   841 SVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKV 905

  Fly  1155 ETIGDAYMVVSGLPVKIPD-HAEQIATMALDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVV 1218
            ||||||||||||||.:... ||.:||.|||.||.....|.::|.|...|:||||:||||.|||||
Mouse   906 ETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVV 970

  Fly  1219 GLTMPRYCLFGDTVNTASRMESTGSSWRIHMSQETRDRLDARGGYAIEPRGLIDIKGKGMMNTFW 1283
            ||.|||||||||||||||||||.|.:.:||:|..|:|.||..|.:.:|.||.:::||||.|.|:|
Mouse   971 GLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYW 1035

  Fly  1284 LLG-KKGFDKPLPAPP 1298
            ||| :||       ||
Mouse  1036 LLGEQKG-------PP 1044

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	Protein Kinases, catalytic domain	763..1041	CDD:473864	111/282 (39%)
		HNOBA	<1047..1095	CDD:462234	22/47 (47%)
		CYCc	1074..1266	CDD:214485	119/192 (62%)
Npr2	NP_776149.1	PBP1_NPR_B	26..421	CDD:380607	79/423 (19%)
		PK_GC-A_B	518..792	CDD:270944	117/298 (39%)
		HNOBA	<798..846	CDD:462234	22/47 (47%)
		CYCc	825..1009	CDD:214485	116/183 (63%)