DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34357 and Adcy2

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	NP_705762.2	Gene:	Adcy2 / 210044	MGIID:	99676	Length:	1095	Species:	Mus musculus

Alignment Length:	302	Identity:	84/302 - (27%)
Similarity:	152/302 - (50%)	Gaps:	55/302 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly  1057 YSNNLEELIRERTE-----------QLDIERKKTEQLLNRMLPSSVAEKL-----------KMGL 1099
            |..:|.||..::|.           :|:.|:::.|:||..:||:.:|.::           |.|.
Mouse   211 YHKHLMELALQQTYRDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQ 275

  Fly  1100 AVDPEEF--------SDVTIYFSDIVGFTTIAAHCSPVQVVDLLNDLYTIFDATINAYNVYKVET 1156
            ..:...|        ::|:|.::||||||.:|:.|||.::|.:||:|:..||.........:::.
Mouse   276 MENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKI 340

  Fly  1157 IGDAYMVVSGLPVKIPDHAEQIATMALDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGLT 1221
            :||.|..|||||:.:|:||:....|.||:.....:  |:...||.:.:|:|:|:|....||:||.
Mouse   341 LGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKK--VRDATGVDINMRVGVHSGNVLCGVIGLQ 403

  Fly  1222 MPRYCLFGDTVNTASRMESTGSSWRIHMSQETRDRLDARGGYAIEPRGLIDIKGKG--------- 1277
            ..:|.::...|..|:.||:.|...|:|:|..|.:.|:  |.|.:|       :|.|
Mouse   404 KWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLN--GAYKVE-------EGDGEIRDPYLKQ 459

  Fly  1278 -MMNTFWLLGKKGFDKPLPAPPPI-GESHGLDESLIRNSITL 1317
             ::.|::::..||..:   :|..: ...|.||.:.:|.|:.:
Mouse   460 HLVKTYFVINPKGERR---SPQHLFRPRHTLDGAKMRASVRM 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	66/210 (31%)
Adcy2	NP_705762.2	AC_N	<37..264	CDD:292831	13/52 (25%)
		CYCc	240..443	CDD:214485	65/206 (32%)
		Guanylate_cyc	285..469	CDD:278633	60/194 (31%)
		DUF1053	499..603	CDD:283888	84/302 (28%)
		CYCc	852..1060	CDD:214485
		Guanylate_cyc	882..1081	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810