DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34357 and ADCY4

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	NP_001185497.1	Gene:	ADCY4 / 196883	HGNCID:	235	Length:	1077	Species:	Homo sapiens

Alignment Length:	285	Identity:	79/285 - (27%)
Similarity:	135/285 - (47%)	Gaps:	53/285 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly  1021 QPDMRP----------------DFNSVYERFKMLNHGRKVNFVDTMFQMLEKYSNNLEELIRERT 1069
            |||.||                :...||.: .::....:..|.:.:..:..:
Human   163 QPDSRPALLPQLAANAVLFLCGNVAGVYHK-ALMERALRATFREALSSLHSR------------- 213

  Fly  1070 EQLDIERKKTEQLLNRMLPSSVAEKLK--------MGLAVDPEEFSD-----------VTIYFSD 1115
            .:||.|:|..|.||..:||:.:|.::|        .|....||..::           |::.::|
Human   214 RRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYAD 278

  Fly  1116 IVGFTTIAAHCSPVQVVDLLNDLYTIFDATINAYNVYKVETIGDAYMVVSGLPVKIPDHAEQIAT 1180
            |||||.:|:.|||.::|.:||:|:..||.....:...:::.:||.|..|||||:.:||||.....
Human   279 IVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVR 343

  Fly  1181 MALDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGSSW 1245
            |.||:.....:  ::...||.:.:|:|:|:|....||:||...:|.::...|..|:.||:.|...
Human   344 MGLDMCRAIRK--LRAATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPG 406

  Fly  1246 RIHMSQETRDRLDARGGYAIEPRGL 1270
            |:|::..|...|  .|.||:|..|:
Human   407 RVHITGATLALL--AGAYAVEDAGM 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	7/35 (20%)
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	67/210 (32%)
ADCY4	NP_001185497.1	AC_N	<115..246	CDD:292831	19/96 (20%)
		CYCc	219..422	CDD:214485	65/206 (32%)
		Guanylate_cyc	264..418	CDD:278633	51/155 (33%)
		DUF1053	479..583	CDD:283888
		CYCc	827..1042	CDD:214485
		Guanylate_cyc	864..1063	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810