Protein Alignment CG34357 and gcy-25

DIOPT Version :9

• Sequence 1: NP_001356914.1
• Gene: CG34357 / 5740349
• FlyBaseID: FBgn0085386
• Length: 1689
• Species: Drosophila melanogaster
• Sequence 2: NP_001294116.1
• Gene: gcy-25 / 191653
• WormBaseID: WBGene00001549
• Length: 1034
• Species: Caenorhabditis elegans
• Alignment Length: 1139
• Identity: 279/1139 - (24%)
• Similarity: 469/1139 - (41%)
• Gaps: 286/1139 - (25%)

  Fly   282 FPAGEEESHSSGET--------EENHWNDARIFS-GHCH-------------------------- 311
            |..|..|..:|.||        ....|.|.|:.| ..||
 Worm    17 FQIGHLEFENSNETRILEICMKNAGSWRDHRLISLPSCHNFNGLENAANLNYQYSVDLLIGAACD 81

  Fly   312 ---QLAEQLALDFNK----------------TVVLWPCPRMKISSNFLPSFEAISLAVQSISTKL 357
               |...:|||.::|                |:.|.|           .|....:..:.::...:
 Worm    82 EETQTVSRLALRWHKLYLSSAPLSTKEKESTTIALKP-----------HSLAGTAEVILAMCKSM 135

  Fly   358 NWSQVDIYIGDDNWGLGLAIAANLHVPYRIEIGRTIRDLHSQDKPGKAIII---TAPLNDASTIL 419
            .|.::.|...::.       ....|..|         |:.::.:....|.:   |..|::..|||
 Worm   136 KWKEIGIIYSEET-------KYTAHAIY---------DMLAEQEDDLKINVFLETDGLSNTYTIL 184

  Fly   420 --------LLSTIELDWTEQARKDGQGSRPGRQHTKILLIDMAASSLDTQHGFYKYLSRMGGSQS 476
                    .|:|::|....:..|: ...||  ....|:.:|...|.:.   .||.||....|.:
 Worm   185 HSARALISFLTTLDLSKFFKTLKE-NAFRP--LEFSIVHVDCNKSEIS---NFYTYLDNNAGEE- 242

  Fly   477 DAFARNTGSPAEVVSSNLLVL----TLLNDRH------RLFLNAAGLMATMQNFRA-------PL 524
                     |..:.::.|..|    .||.:.|      ..|....||:.:...::|       .|
 Worm   243 ---------PNPISAARLRKLYRHVALLKNSHDDMEKTEEFAKKYGLVPSYTLYKALILCDGLQL 298

  Fly   525 NGNYKDPPPSGHRNASLHKLYPYRNLLPLYDTIVTTTTQSDTSETSPQFDFVVLDIVRDAPVATY 589
            ..||..|    ..|.|:.:..||     |::.:..|.||..:...     |:..|.||......:
 Worm   299 LNNYTAP----RGNLSIVQQLPY-----LWNHVTNTETQGYSGPV-----FIGNDGVRLPYYEMH 349

  Fly   590 KWRP--------LLILESDPGSRGGGSVVEGGGSYISHS-----IHP-----GYDEWLLVSSVLL 636
            .||.        :...|||   ..||::.:....::..|     :.|     |||..|
 Worm   350 MWRDGKAVHVANVKPRESD---YCGGNMTKNCYEFLPSSPLLEDLPPYTSDCGYDNNL------- 404

  Fly   637 WQCGAI-CWTIAAICVCLLVIMIAGIVAGGIAMRNYFLRKR--LSKGPNKIVLSASDFVFPVDSR 698
              |... .:.||||...:|:|.:|      ||.  |..||.  :.:.|.::         |:||.
 Worm   405 --CSDFHVFMIAAIVFSILLIPMA------IAF--YLQRKEHLIQQMPWRV---------PLDSI 450

  Fly   699 RVDEGIEAMLCCWLQQLQEFGGPEVDKPDLLKGSIGSLKNLGFVIPGAAAPGSAGAITTTANGKS 763
            ..|:.                          .||:.:.:.:..:              :||....
 Worm   451 SFDDN--------------------------GGSLSASRRVSTI--------------STARASY 475

  Fly   764 GSSATGSLARHNPAHLDMRARYNGDLVQLKEVNINGSAELRT-----KAMDLLVMAHGLRHENIN 823
            .|..:|::|.|             .:|..::|::....:.|.     :.|::|.....:.|.|||
 Worm   476 SSIFSGNVAEH-------------AIVNKQKVSVKRHVQRRAITFSRQEMEMLNQLKYMSHTNIN 527

  Fly   824 PLIG-WLSDPNRTAMVFDYCSRGSLQDVLIMDEIKLDWSFRLSLLTDLVRGMRYLHTSPLRVHGA 887
            |..| ..:..:...:::.:.:|.||:|::.:.|.|...:|:.:.:..:|.|:.|:|.|.::||||
 Worm   528 PFTGICFNQGSELIVMWQFTTRYSLEDLIFVKEQKFGRNFQSTFIKHIVHGINYIHNSSIKVHGA 592

  Fly   888 LTSRNCVVDARWVLKITDYGLNSFYESQGLPPRTRSAKEL---------------LWTAPELLRN 937
            |...|||||:.||:|:||:|:      :|:.....:.|||               |..|||.:..
 Worm   593 LYLSNCVVDSYWVVKLTDFGI------KGILKERTNHKELAPSSAFDVDAIHYKYLQLAPEHISA 651

  Fly   938 M--KLHQHHHQHGRIQLGTQLGDVYSFGIIMQEVVVRGEPYCMLSLSPEEI--IVKIKKPPPLIR 998
            :  ||.:..        ||..||:|...:.:.:::....|:.....|.:|:  ::..:...|| .
 Worm   652 ILEKLEEPR--------GTVEGDIYQLAMCIYQILFYMRPFAERQESIKELAHLLSSQSTAPL-H 707

  Fly   999 PSVSKG-AAPPEAINIMRQCWAEQPDMRPDFNSVYERF-KMLNHGRKVNFVDTMFQMLEKYSNNL 1061
            |.|.:| :.....::|::|||..:|..||....:.:.. :......|...:|.|.:|:::||.||
 Worm   708 PKVPEGNSFTMRLLSIIQQCWLYKPAARPALIKITDAVNREFGQDVKGTLIDQMIEMIDEYSANL 772

  Fly  1062 EELIRERTEQLDIERKKTEQLLNRMLPSSVAEKLKMGLAVDPEEFSDVTIYFSDIVGFTTIAAHC 1126
            |:::.|||.:|:.:...||.||.::||.|||:.::.|..|.||:.|.||:...|:..||......
 Worm   773 EQIVAERTRELEQDMSVTENLLYQLLPKSVADSIRSGKTVVPEQHSSVTLLVVDVCQFTKFCEAF 837

  Fly  1127 SPVQVVDLLNDLYTIFDATINAYNVYKVETIGDAYMVVSGLP-VKIPDHAEQIATMALDLLHQSG 1190
            .||.:::.|.:||:.||..:.....:|||.:||||::.||:| :....|..:|..::|.|.....
 Worm   838 IPVHILETLQELYSSFDNIVQKNKAFKVENVGDAYLICSGIPEMSGFRHLREICKISLKLQAFMK 902

  Fly  1191 RFNVKHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGSSWRIHMSQETRD 1255
            .|.|:|.|...||:::|:.:|...||::|.|.||:|:||||||.|.||.|||:...|.:|:.|.:
 Worm   903 TFKVRHRPSHTLQIKMGITSGAVAAGILGSTAPRFCIFGDTVNMACRMASTGNPGSIQLSELTAN 967

  Fly  1256 RL-DARGGYAIEPRGLIDIKGKGMMNTFWLLGKK 1288
            .| :....:.:|.||:||:||||...||||.|:|
 Worm   968 TLMEKFPSFMLEERGMIDVKGKGACLTFWLTGEK 1001

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	73/304 (24%)
		CYCc	1074..1266	CDD:214485	71/193 (37%)
gcy-25	NP_001294116.1	PBP1_iGluR_N_LIVBP_like	56..>230	CDD:107346	29/206 (14%)
		PKc_like	473..746	CDD:304357	73/300 (24%)
		SPS1	474..>736	CDD:223589	71/289 (25%)
		HNOBA	<764..805	CDD:285003	19/40 (48%)
		CYCc	790..976	CDD:214485	71/185 (38%)
		Nucleotidyl_cyc_III	812..999	CDD:299850	74/186 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770